MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
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Protein kinase MELK has oncogenic properties and is highly overexpressed in some tumors. In the present study, we show that a novel MELK inhibitor causes both the inhibition and degradation of MELK, culminating in replication stress and a senescence phenotype.
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2014 ◽
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2004 ◽
Vol 64
(13)
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pp. 4394-4399
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2006 ◽
Vol 66
(3)
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pp. 1767-1774
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2009 ◽
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2010 ◽
Vol 9
(5)
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pp. 1136-1146
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2020 ◽
2017 ◽
Vol 16
(10)
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pp. 2058-2068
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