scholarly journals Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

2004 ◽  
Vol 64 (13) ◽  
pp. 4394-4399 ◽  
Author(s):  
Lin Yang ◽  
Han C. Dan ◽  
Mei Sun ◽  
Qiyuan Liu ◽  
Xia-meng Sun ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Small Molecule ◽  
Protein Kinase B ◽  
Small Molecule Inhibitor ◽  
Akt Signaling ◽  
Molecule Inhibitor

scholarly journals MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

2015 ◽  
Vol 35 (6) ◽  
Author(s):  
Lijs Beke ◽  
Cenk Kig ◽  
Joannes T. M. Linders ◽  
Shannah Boens ◽  
An Boeckx ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Small Molecule ◽  
Damage Tolerance ◽  
Replication Stress ◽  
Small Molecule Inhibitor ◽  
Dna Damage Tolerance ◽  
Molecule Inhibitor ◽  
Senescence Phenotype

Protein kinase MELK has oncogenic properties and is highly overexpressed in some tumors. In the present study, we show that a novel MELK inhibitor causes both the inhibition and degradation of MELK, culminating in replication stress and a senescence phenotype.

A Novel Small-Molecule Inhibitor of Protein Kinase Cι Blocks Transformed Growth of Non–Small-Cell Lung Cancer Cells

2006 ◽  
Vol 66 (3) ◽  
pp. 1767-1774 ◽  
Author(s):  
Melody Stallings-Mann ◽  
Lee Jamieson ◽  
Roderick P. Regala ◽  
Capella Weems ◽  
Nicole R. Murray ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Kinase ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Small Molecule ◽  
Cell Lung Cancer ◽  
Small Molecule Inhibitor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Molecule Inhibitor

Novel small molecule inhibitor of Kpnβ1 induces cell cycle arrest and apoptosis in cancer cells

2021 ◽  
pp. 112637
Author(s):  
Aderonke Ajayi-Smith ◽  
Pauline van der Watt ◽  
Nonkululeko Mkwanazi ◽  
Sarah Carden ◽  
John O. Trent ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cycle Arrest ◽  
Molecule Inhibitor ◽  
Apoptosis In Cancer Cells

scholarly journals A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

2010 ◽  
Vol 9 (5) ◽  
pp. 1136-1146 ◽  
Author(s):  
Kuzhuvelil B. Harikumar ◽  
Ajaikumar B. Kunnumakkara ◽  
Nobuo Ochi ◽  
Zhimin Tong ◽  
Amit Deorukhkar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cancer Growth ◽  
Protein Kinase D ◽  
Molecule Inhibitor
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