Abstract B21: The difference in the role of PI3K/Akt/mTOR pathway between oropharyngeal squamous cell carcinoma and oral cavity squamous cell carcinoma.

2011 ◽  
Author(s):  
Hye Sung Won ◽  
Ji Hyung Hong ◽  
Eun Kyoung Jeon ◽  
Yoon Ho Ko ◽  
Sang Hoon Chun ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mtor Pathway ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
The Difference

scholarly journals Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma

2020 ◽  
Author(s):  
Shunsuke Kondo ◽  
Hitoshi Hirakawa ◽  
Taro Ikegami ◽  
Takayuki Uehara ◽  
Shinya Agena ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Mtor Pathway ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
High Gene ◽  
Complex Expression

Abstract Background Despite reports of a link between human papillomavirus (HPV) infection and mechanistic target of rapamycin (mTOR) signaling activation, the role of the mTOR pathway, especially raptor and rictor, in HPV-related head and neck cancer is still unclear. The aim of the present study was to elucidate the role of the mTOR pathway in HPV-related oropharyngeal squamous cell carcinoma (OPSCC). Methods The present study involved two strategies. The first was to investigate the activity of mTOR and mTOR-related complexes in high-risk HPV-positive (UM-SCC47 and CaSki) and HPV-negative (SCC-4 and SAS) cancer cell lines. The second was to elucidate mTOR complex expression in 80 oropharyngeal cancer tissues and to examine the relationship between mTOR complex expression and survival in patients with OPSCC. Results The UM-SCC47 and CaSki cell lines showed high gene and protein expression of raptor. They also exhibited G1/S and G2/M phase cell cycle arrest following 24 h incubation with 6 μM temsirolimus, a rapamycin analog, and temsirolimus administration inhibited their growth. HPV-related OPSCC samples showed high gene expression of raptor and rictor compared with HPV-unrelated OPSCC. In addition, HPV-related OPSCC patients with high raptor and rictor expression tended to have a worse prognosis than those with low or medium expression. Conclusions These results suggest that raptor has an important role in HPV-related OPSCC and that temsirolimus is a potential therapeutic agent for patients with HPV-related OPSCC. This is the first report to reveal overexpression of raptor and rictor in HPV-related OPSCC.

scholarly journals Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
F. Farshadpour ◽  
S. Konings ◽  
E. J. M Speel ◽  
G. J. Hordijk ◽  
R. Koole ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Stage ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Fish Analysis ◽  
Hpv Dna ◽  
Negative Tumor ◽  
Matching Criteria

We aimed to determine the role of HPV in the pathogenesis and outcome of oropharyngeal squamous cell carcinoma (OSCC) in lifelong nonsmoking and nondrinking patients. A case-case analysis was performed to compare the presence of HPV-DNA in tumor cells of 16 nonsmoking and nondrinking with 16 matched smoking and drinking patients (matching criteria: age at incidence, gender, tumor sublocation, tumor stage). HPV was detected using 2 PCR tests, FISH analysis, and p16INK4A immunostaining. Nonsmoking and nondrinking patients had more HPV-positive tumors than smoking and drinking patients (n=12; 75% versus n=2; 13%; P<0.001). All HPV-positive tumors showed p16INK4A overexpression, and 1 HPV-negative tumor had p16INK4A overexpression, (P<0.001). Overall survival and disease-specific survival were higher for HPV-positive compared to HPV-negative cases (P=0.027, P=0.039, resp.). In conclusion, HPV is strongly associated with OSCC of nonsmoking and nondrinking patients. Specific diagnostic and therapeutic actions should be considered for these patients to achieve a better prognosis.

Retrospective cohort study of prognostic factors in patients with oral cavity and oropharyngeal squamous cell carcinoma

Head & Neck ◽  
2015 ◽  
Vol 38 (4) ◽  
pp. 536-541 ◽  
Author(s):  
José F. Carrillo ◽  
Liliana C. Carrillo ◽  
Ana Cano ◽  
Margarita C. Ramirez-Ortega ◽  
Jorge G. Chanona ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cohort Study ◽  
Prognostic Factors ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Oropharyngeal Squamous Cell Carcinoma
Sign in / Sign up

Export Citation Format

Share Document