Abstract C188: RalA phosphorylation as a biomarker in pancreatic ductal adenocarcinoma for Aurora A kinase inhibition in response to the investigational agent MLN8237.

2011 ◽  
Author(s):  
Nicole F. Neel ◽  
Jeffrey A. Escedy ◽  
Vaishali Shinde ◽  
Channing J. Der ◽  
Jen Jen Yeh
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition ◽  
Investigational Agent

scholarly journals Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death

2019 ◽  
Vol 80 (4) ◽  
pp. 832-842 ◽  
Author(s):  
Johannes Ommer ◽  
Joanna L. Selfe ◽  
Marco Wachtel ◽  
Eleanor M. O'Brien ◽  
Dominik Laubscher ◽  
...  
Keyword(s):  
Cell Death ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition ◽  
Rhabdomyosarcoma Cell

scholarly journals Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation

Oncotarget ◽  
2017 ◽  
Vol 8 (11) ◽  
pp. 17412-17427 ◽  
Author(s):  
Mark A. Currier ◽  
Les Sprague ◽  
Tilat A. Rizvi ◽  
Brooke Nartker ◽  
Chun-Yu Chen ◽  
...  
Keyword(s):  
Immune Modulation ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition ◽  
Cellular Immune

scholarly journals 666. Oncolytic Herpes Virotherapy Induces a Paracrine Death Signal Causing Synergistic Antitumor Efficacy with Aurora A Kinase Inhibition

2016 ◽  
Vol 24 ◽  
pp. S263-S264
Author(s):  
Leslee Sprague ◽  
Mark Currier ◽  
Tilat Rizvi ◽  
Brooke Nartker ◽  
Chun-Yu Chen ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition

Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe

2010 ◽  
Vol 297 (2) ◽  
pp. 171-181 ◽  
Author(s):  
June-Won Cheong ◽  
Haeng-Im Jung ◽  
Ju In Eom ◽  
Soo Jung Kim ◽  
Hoi-Kyung Jeung ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytosine Arabinoside ◽  
Leukemia Cells ◽  
Mitotic Catastrophe ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition

scholarly journals Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism

2012 ◽  
Vol 131 (11) ◽  
pp. 2693-2703 ◽  
Author(s):  
Kevin R. Kelly ◽  
Steffan T. Nawrocki ◽  
Claudia M. Espitia ◽  
Mengkun Zhang ◽  
Johnny J. Yang ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Investigational Agent ◽  
Dependent Mechanism

scholarly journals Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

2015 ◽  
Vol 21 (18) ◽  
pp. 4097-4109 ◽  
Author(s):  
Kelly M. Zullo ◽  
Yige Guo ◽  
Laurence Cooke ◽  
Xavier Jirau-Serrano ◽  
Michael Mangone ◽  
...  
Keyword(s):  
T Cell ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition ◽  
Deacetylase Inhibitor

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene

2018 ◽  
Vol 9 (2) ◽  
pp. 248-263 ◽  
Author(s):  
Xueqian Gong ◽  
Jian Du ◽  
Stephen H. Parsons ◽  
Farhana F. Merzoug ◽  
Yue Webster ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition ◽  
Synthetic Lethal

scholarly journals 432. Aurora A Kinase Inhibition Enhances Oncolytic Herpes Simplex Virotherapy in Models of Neuroblastoma

2015 ◽  
Vol 23 ◽  
pp. S171
Author(s):  
Mark Currier ◽  
Tilat Rizvi ◽  
Brooke Nartker ◽  
Duo Chen ◽  
Pin-Yi Wang ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition
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