Abstract P006: Novel machine-learning tools improve cost-effective development of personalised immunotherapies: Lowering false positive rates in the search for actionable (personalised and largely shared) immunogenic neoantigens

Author(s):  
Cedric Bogaert ◽  
Lena Pfitzer ◽  
Nil Adell Mill ◽  
Bruno Fant
2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Dae Y. Kang ◽  
Pamela N. DeYoung ◽  
Justin Tantiongloc ◽  
Todd P. Coleman ◽  
Robert L. Owens

AbstractMachine learning has the potential to change the practice of medicine, particularly in areas that require pattern recognition (e.g. radiology). Although automated classification is unlikely to be perfect, few modern machine learning tools have the ability to assess their own classification confidence to recognize uncertainty that might need human review. Using automated single-channel sleep staging as a first implementation, we demonstrated that uncertainty information (as quantified using Shannon entropy) can be utilized in a “human in the loop” methodology to promote targeted review of uncertain sleep stage classifications on an epoch-by-epoch basis. Across 20 sleep studies, this feedback methodology proved capable of improving scoring agreement with the gold standard over automated scoring alone (average improvement in Cohen’s Kappa of 0.28), in a fraction of the scoring time compared to full manual review (60% reduction). In summary, our uncertainty-based clinician-in-the-loop framework promotes the improvement of medical classification accuracy/confidence in a cost-effective and economically resourceful manner.


2019 ◽  
Vol 7 (4) ◽  
pp. 184-190
Author(s):  
Himani Maheshwari ◽  
Pooja Goswami ◽  
Isha Rana

2019 ◽  
Vol 20 (5) ◽  
pp. 488-500 ◽  
Author(s):  
Yan Hu ◽  
Yi Lu ◽  
Shuo Wang ◽  
Mengying Zhang ◽  
Xiaosheng Qu ◽  
...  

Background: Globally the number of cancer patients and deaths are continuing to increase yearly, and cancer has, therefore, become one of the world&#039;s highest causes of morbidity and mortality. In recent years, the study of anticancer drugs has become one of the most popular medical topics. </P><P> Objective: In this review, in order to study the application of machine learning in predicting anticancer drugs activity, some machine learning approaches such as Linear Discriminant Analysis (LDA), Principal components analysis (PCA), Support Vector Machine (SVM), Random forest (RF), k-Nearest Neighbor (kNN), and Naïve Bayes (NB) were selected, and the examples of their applications in anticancer drugs design are listed. </P><P> Results: Machine learning contributes a lot to anticancer drugs design and helps researchers by saving time and is cost effective. However, it can only be an assisting tool for drug design. </P><P> Conclusion: This paper introduces the application of machine learning approaches in anticancer drug design. Many examples of success in identification and prediction in the area of anticancer drugs activity prediction are discussed, and the anticancer drugs research is still in active progress. Moreover, the merits of some web servers related to anticancer drugs are mentioned.


2020 ◽  
Author(s):  
Anurag Sohane ◽  
Ravinder Agarwal

Abstract Various simulation type tools and conventional algorithms are being used to determine knee muscle forces of human during dynamic movement. These all may be good for clinical uses, but have some drawbacks, such as higher computational times, muscle redundancy and less cost-effective solution. Recently, there has been an interest to develop supervised learning-based prediction model for the computationally demanding process. The present research work is used to develop a cost-effective and efficient machine learning (ML) based models to predict knee muscle force for clinical interventions for the given input parameter like height, mass and angle. A dataset of 500 human musculoskeletal, have been trained and tested using four different ML models to predict knee muscle force. This dataset has obtained from anybody modeling software using AnyPyTools, where human musculoskeletal has been utilized to perform squatting movement during inverse dynamic analysis. The result based on the datasets predicts that the random forest ML model outperforms than the other selected models: neural network, generalized linear model, decision tree in terms of mean square error (MSE), coefficient of determination (R2), and Correlation (r). The MSE of predicted vs actual muscle forces obtained from the random forest model for Biceps Femoris, Rectus Femoris, Vastus Medialis, Vastus Lateralis are 19.92, 9.06, 5.97, 5.46, Correlation are 0.94, 0.92, 0.92, 0.94 and R2 are 0.88, 0.84, 0.84 and 0.89 for the test dataset, respectively.


2021 ◽  
Vol 192 ◽  
pp. 103181
Author(s):  
Jagadish Timsina ◽  
Sudarshan Dutta ◽  
Krishna Prasad Devkota ◽  
Somsubhra Chakraborty ◽  
Ram Krishna Neupane ◽  
...  

i-com ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 19-32
Author(s):  
Daniel Buschek ◽  
Charlotte Anlauff ◽  
Florian Lachner

Abstract This paper reflects on a case study of a user-centred concept development process for a Machine Learning (ML) based design tool, conducted at an industry partner. The resulting concept uses ML to match graphical user interface elements in sketches on paper to their digital counterparts to create consistent wireframes. A user study (N=20) with a working prototype shows that this concept is preferred by designers, compared to the previous manual procedure. Reflecting on our process and findings we discuss lessons learned for developing ML tools that respect practitioners’ needs and practices.


2021 ◽  
Vol 59 ◽  
pp. 102353
Author(s):  
Amber Grace Young ◽  
Ann Majchrzak ◽  
Gerald C. Kane

Author(s):  
Hector Donaldo Mata ◽  
Mohammed Hadi ◽  
David Hale

Transportation agencies utilize key performance indicators (KPIs) to measure the performance of their traffic networks and business processes. To make effective decisions based on these KPIs, there is a need to align the KPIs at the strategic, tactical, and operational decision levels and to set targets for these KPIs. However, there has been no known effort to develop methods to ensure this alignment producing a correlative model to explore the relationships to support the derivation of the KPI targets. Such development will lead to more realistic target setting and effective decisions based on these targets, ensuring that agency goals are met subject to the available resources. This paper presents a methodology in which the KPIs are represented in a tree-like structure that can be used to depict the association between metrics at the strategic, tactical, and operational levels. Utilizing a combination of business intelligence and machine learning tools, this paper demonstrates that it is possible not only to identify such relationships but also to quantify them. The proposed methodology compares the effectiveness and accuracy of multiple machine learning models including ordinary least squares regression (OLS), least absolute shrinkage and selection operator (LASSO), and ridge regression, for the identification and quantification of interlevel relationships. The output of the model allows the identification of which metrics have more influence on the upper-level KPI targets. The analysis can be performed at the system, facility, and segment levels, providing important insights on what investments are needed to improve system performance.


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