Abstract 2624: Evaluation of the association of the ABO blood group SNP rs505922 with breast cancer phenotypes

The current study included 200 patients with breast cancer that resemble to patient samples were collected from AL-Nassyria hospital also 279 samples as control which was collected from blood bank at ALNassiryia province . The study attempted to correlate ABO blood group with incidence to breast cancer .The results shown that type A of ABO blood group high frequency then followed by type O with in AL-Nassyria region also the results reported that A, B, O and AB blood groups frequencies of patient samples percentage were 60%, 20%, 10% and 10% respectively as well as the ABO blood groups frequencies of control samples percentage were 26%, 28%,38% and 8% respectively. The results observed there is high significant differences between ABO blood group frequencies of cancer patients and ABO blood group frequencies of control samples .The results indicated that the blood type should be considered one of risk factor as well as regarded as preclinical marker.

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ABO blood group and the risk of breast cancer: Multicenter, case-control, observational study.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.1572 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 1572-1572

Author(s):

Yuksel Urun ◽

Tulay Koru-Sengul ◽

Kadri Altundag ◽

Gungor Utkan ◽

Handan Onur ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Blood Group ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Blood Types ◽

Abo Blood Type

1572 Background: The role of genetic factors in the development of cancer is widely accepted. ABO blood type is an inherited characteristic and previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in breast cancer is inconclusive. Methods: All patients who had breast cancer (BC) and treated between 2000-2010 at the Departments of Medical Oncology of both Ankara and Hacettepe Universities (Ankara, Turkey) with defined ABO blood type and Rh factor were included in our retrospective reviews of tumor registry records. A group of volunteer healthy women donors of Turkish Red Crescent between 2004-2011 were identified as a control group, without any matching factors. The relationship of ABO blood types and Rh factor with various prognostic factors such as age at diagnosis, menopausal status, family history of breast cancer, and ER/PR/HER2 status were evaluated from 1740 BC patients. We compared the distributions of ABO blood types, Rh factors among 1740 patients and 204,553 healthy controls. Among BC patients, differences between each of aforementioned ABO blood groups and Rh factors with respect to various prognostic factors were explored, respectively. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (44% A, 8% AB, 16% B, 32% O, 88% Rh+) and controls (41% A, 8% AB, 16% B, 35% O, 87% Rh+). However, there were statistically significant differences between patients and controls with respect to A vs. nonA (p=0.019) and marginal significance (p=0.051) for O vs. nonO. Among patients, there were statistically significant differences between A and nonA with respect to HER2 (p=0.0421), M stage (p=0.0447), T stage (p=0.0020). Only T stage (p=0.0337) were significantly different between O vs nonO. Grade (p=0.0227) and M stage (p=0.0107) were significantly different between Rh factors. Conclusions: In our study sample, ABO blood type was statistically significantly associated with breast cancer. Additional studies are necessary to determine the mechanisms by which ABO blood type may influence the risk of breast cancer.

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ASSOCIATION OF ABO BLOOD GROUP AND BREAST CANCER- A RETROSPECTIVE STUDY IN ERBIL CITY

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2018/918 ◽

2018 ◽

Vol 7 (37) ◽

pp. 4106-4108

Author(s):

Samir Anwar Jabbar ◽

Nooraddin Ismail

Keyword(s):

Breast Cancer ◽

Retrospective Study ◽

Blood Group ◽

Abo Blood Group

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Association of ABO Blood Group and Risk of Breast Cancer

Journal of Blood Disorders & Transfusion ◽

10.4172/2155-9864.1000241 ◽

2014 ◽

Vol 05 (09) ◽

Cited By ~ 2

Author(s):

Rabab Aly ◽

Ansaf Yousef

Keyword(s):

Breast Cancer ◽

Blood Group ◽

Abo Blood Group

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A Study of Association of ABO Blood Group types with Cancer Risk

10.1101/796284 ◽

2019 ◽

Author(s):

Vishal Singh ◽

Upendra Yadav ◽

Vandana Rai ◽

Pradeep Kumar

Keyword(s):

Breast Cancer ◽

Gastric Cancer ◽

Cancer Risk ◽

Blood Group ◽

Medical Science ◽

Study Data ◽

Abo Blood Group ◽

Blood Group System ◽

Group System ◽

Males And Females

ABSTRACTMore than 30 blood group systems have been recognized by International Society of Blood Transfusion (ISBT). ABO blood group is one of the most studied blood group system. ABO blood group system consist of three alleles A, B and O, out which A and B are co-dominant and O is recessive. Many researchers and investigators have found association between ABO blood group and cancer risk. It was found from the recent data that blood group A and AB is associated with increased pancreatic and gastric cancer risk. In the present study data of ABO blood group of 243 patients, both males and females, with confirmed cases of cancer was obtained from Sir Sunderlal hospital, Institute of Medical Science (IMS), Banaras Hindu University (BHU) and Apex hospital, DLW Road, Varanasi. 250 Samples of both males and females were taken as control. Out of 243 cancer patients 117 were males and 126 were females. In 243 cases enrolled in present study, highest number of cases were of breast cancer among women and lowest were rectal cancer. It was found that A blood group was associated with breast cancer, oral cancer, liver cancer and ovarian cancer as compared to other blood group and blood group O was associated with lung cancer, gastric cancer, colon cancer, skin cancer and endometrial cancer.

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