ABO blood group and the risk of breast cancer: Multicenter, case-control, observational study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1572-1572
Author(s):  
Yuksel Urun ◽  
Tulay Koru-Sengul ◽  
Kadri Altundag ◽  
Gungor Utkan ◽  
Handan Onur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Blood Types ◽  
Abo Blood Type

1572 Background: The role of genetic factors in the development of cancer is widely accepted. ABO blood type is an inherited characteristic and previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in breast cancer is inconclusive. Methods: All patients who had breast cancer (BC) and treated between 2000-2010 at the Departments of Medical Oncology of both Ankara and Hacettepe Universities (Ankara, Turkey) with defined ABO blood type and Rh factor were included in our retrospective reviews of tumor registry records. A group of volunteer healthy women donors of Turkish Red Crescent between 2004-2011 were identified as a control group, without any matching factors. The relationship of ABO blood types and Rh factor with various prognostic factors such as age at diagnosis, menopausal status, family history of breast cancer, and ER/PR/HER2 status were evaluated from 1740 BC patients. We compared the distributions of ABO blood types, Rh factors among 1740 patients and 204,553 healthy controls. Among BC patients, differences between each of aforementioned ABO blood groups and Rh factors with respect to various prognostic factors were explored, respectively. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (44% A, 8% AB, 16% B, 32% O, 88% Rh+) and controls (41% A, 8% AB, 16% B, 35% O, 87% Rh+). However, there were statistically significant differences between patients and controls with respect to A vs. nonA (p=0.019) and marginal significance (p=0.051) for O vs. nonO. Among patients, there were statistically significant differences between A and nonA with respect to HER2 (p=0.0421), M stage (p=0.0447), T stage (p=0.0020). Only T stage (p=0.0337) were significantly different between O vs nonO. Grade (p=0.0227) and M stage (p=0.0107) were significantly different between Rh factors. Conclusions: In our study sample, ABO blood type was statistically significantly associated with breast cancer. Additional studies are necessary to determine the mechanisms by which ABO blood type may influence the risk of breast cancer.

scholarly journals Relationship between ABO blood group and breast cancer at AL-Nassyria city / Iraq

2008 ◽  
pp. 26-29
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Cancer Patients ◽  
Blood Group ◽  
High Frequency ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Control Samples

The current study included 200 patients with breast cancer that resemble to patient samples were collected from AL-Nassyria hospital also 279 samples as control which was collected from blood bank at ALNassiryia province . The study attempted to correlate ABO blood group with incidence to breast cancer .The results shown that type A of ABO blood group high frequency then followed by type O with in AL-Nassyria region also the results reported that A, B, O and AB blood groups frequencies of patient samples percentage were 60%, 20%, 10% and 10% respectively as well as the ABO blood groups frequencies of control samples percentage were 26%, 28%,38% and 8% respectively. The results observed there is high significant differences between ABO blood group frequencies of cancer patients and ABO blood group frequencies of control samples .The results indicated that the blood type should be considered one of risk factor as well as regarded as preclinical marker.

scholarly journals ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis

2020 ◽  
Vol 3 (1) ◽  
pp. 71-84
Author(s):  
Richard Chinaza Ikeagwulonu ◽  
◽  
Chinonyelum Thecla Ezeonu ◽  
Mark Uchejeso Obeta ◽  
Ngozi Immaculata Ugwu ◽  
...  
Keyword(s):  
Blood Group ◽  
Meta Analysis ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Blood Group A ◽  
Search Terms ◽  
Group A

Introduction: Conflicting evidences exist that ABO blood groups correlate with the susceptibility to COVID-19 and its clinical outcomes. This study aimed to pool available articles that assessed a possible relationship between COVID-19 and ABO blood groups. Materials and methods: A search was conducted in four databases comprising Pubmed/Medline, Google scholar, Journal storage (JSTOR) and African Journals Online (AJOL) for relevant studies available before 25th August 2020 and contained extractable data on ABO blood type distribution and COVID-19 disease. Search terms included a combination of “ABO blood group, and COVID-19, coronavirus, and SARS-COV-2”. Results: Fourteen articles that met study inclusion criteria were selected from a total of five hundred and eighty-five articles identified through database search. The fourteen articles reviewed comprised of a total of 73934 subjects (13189 SARS-COV-2 positive cases and 60745 controls). Overall, the risk of SARS-COV-2 infection was found to be significantly increased in patients with blood group A with ORs: 1.24 (95%Cl: 1.09-1.41, P = 0.001). Additionally, blood group O subjects were seen to have decreased odds of contracting COVID-19 infection (OR: 0.78, 95%Cl: 0.68 – 0.89, P=0.0003). No significant association was found between ABO blood groups and COVID -19 severity and mortality. Conclusions: Blood group A was associated with a higher risk of SARS-COV-2 infection whereas risk of infection was lower in blood group O subjects. No statistical significant association was found between ABO blood groups and COVID-19 severity and mortality. The precise role of ABO blood group in COVID-19 susceptibility, severity and mortality requires further research for clarification.

scholarly journals Human ABO Blood Groups and Their Associations with Different Diseases

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Silamlak Birhanu Abegaz
Keyword(s):  
Cognitive Impairment ◽  
Cardiovascular Diseases ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Groups ◽  
E Coli ◽  
Salmonella Infections ◽  
Increased Risk ◽  
Abo Blood Type

Introduction. Human ABO blood type antigens exhibit alternative phenotypes and genetically derived glycoconjugate structures that are located on the red cell surface which play an active role in the cells’ physiology and pathology. Associations between the blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. However, due to lack of antigens of some blood groups, there have been some contentious issues with the association between the ABO blood group and vulnerability to certain infectious and noninfectious diseases. Objective. To review different literatures that show the association between ABO blood groups and different diseases. Method. Original, adequate, and recent articles on the same field were researched, and the researcher conducted a comprehensive review on this topic. Thus, taking out critical discussions, not only a descriptive summary of the topic but also contradictory ideas were fully retrieved and presented in a clear impression. In addition, some relevant scientific papers published in previous years were included. The article search was performed by matching the terms blood types/groups with a group of terms related to different diseases. The articles were screened and selected based on the title and abstract presented. Results. The susceptibility to various diseases, such as cancer, cardiovascular diseases, infections and hematologic disorders, cognitive disorders, circulatory diseases, metabolic diseases, and malaria, has been linked with ABO blood groups. Moreover, blood group AB individuals were found to be susceptible to an increased risk of cognitive impairment which was independent of geographic region, age, race, and gender. Disorders such as hypertension, obesity, dyslipidemia, cardiovascular disease (CVD), and diabetes were also more prevalent in individuals with cognitive impairment. Early etiological studies indicated that blood type O has a connection with increased incidence of cholera, plague, tuberculosis infections, and mumps, whereas blood type A is linked with increased incidence of smallpox and Pseudomonas aeruginosa infection; blood type B is also associated with increased incidence of gonorrhea, tuberculosis, and Streptococcus pneumoniae, E. coli, and salmonella infections; and blood type AB is associated with increased incidence of smallpox and E. coli and salmonella infections. Diabetes mellitus, hypercholesterolemia, arterial hypertension, and family history for ischemic heart disease are the most common risk factors for cardiovascular diseases and can be genetically transmitted to offspring. Higher incidence of cancers in the stomach, ovaries, salivary glands, cervix, uterus, and colon/rectum was common in blood type A people than in O type people. The link between the ABO blood type and thromboembolic diseases and bleeding risk are intervened by the glycosyltransferase activity and plasma levels and biologic activity of vWF (Von Willebrand factor), a carrier protein for coagulation factor VIII which is low in O type. Conclusion. Several studies related to the ABO phenotype show that genetically determined human ABO blood groups were correspondingly linked with an increased risk of various infectious and noninfectious diseases. However, further investigations are needed particularly on the molecular level of ABO blood groups and their association with various diseases.

scholarly journals Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

2022 ◽  
Vol 8 ◽  
Author(s):  
Herbert F. Jelinek ◽  
Mira Mousa ◽  
Nawal Alkaabi ◽  
Eman Alefishat ◽  
Gihan Daw Elbait ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Blood Group ◽  
Population Sample ◽  
Blood Groups ◽  
Blood Type ◽  
Candidate Gene Approach ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Allelic Variants ◽  
A Genome

Introduction: Coronavirus disease 2019 (COVID-19) disease severity differs widely due to numerous factors including ABO gene-derived susceptibility or resistance. The objective of this study was to investigate the association of the ABO blood group and genetic variations of the ABO gene with COVID-19 severity in a heterogeneous hospital population sample from the United Arab Emirates, with the use of an epidemiological and candidate gene approach from a genome-wide association study (GWAS).Methods: In this cross-sectional study, a total of 646 participants who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited from multiple hospitals and population-based (quarantine camps) recruitment sites from March 2020 to February 2021. The participants were divided into two groups based on the severity of COVID-19: noncritical (n = 453) and critical [intensive care unit (ICU) patients] (n = 193), as per the COVID-19 Reporting and Data System (CO-RADS) classification. The multivariate logistic regression analysis demonstrated the association of ABO blood type as well as circulating anti-A antibodies and anti-B antibodies as well as A and B antigens, in association with critical COVID-19 hospital presentation. A candidate gene analysis approach was conducted from a GWAS where we examined 240 single nucleotide polymorphisms (SNPs) (position in chr9: 136125788-136150617) in the ABO gene, in association with critical COVID-19 hospital presentation.Results: Patients with blood group O [odds ratio (OR): 0.51 (0.33, 0.79); p = 0.003] were less likely to develop critical COVID-19 symptoms. Eight alleles have been identified to be associated with a protective effect of blood group O in ABO 3'untranslated region (UTR): rs199969472 (p = 0.0052), rs34266669 (p = 0.0052), rs76700116 (p = 0.0052), rs7849280 (p = 0.0052), rs34039247 (p = 0.0104), rs10901251 (p = 0.0165), rs9411475 (p = 0.0377), and rs13291798 (p = 0.0377).Conclusion: Our findings suggest that there are novel allelic variants that link genetic variants of the ABO gene and ABO blood groups contributing to the reduced risk of critical COVID-19 disease. This study is the first study to combine genetic and serological evidence of the involvement of the ABO blood groups and the ABO gene allelic associations with COVID-19 severity within the Middle Eastern population.

scholarly journals ABO Blood Groups and the Risk of Venous Thromboembolism (VTE) Among Saudi Patients at a Tertiary Care Hospital in Riyadh

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4926-4926
Author(s):  
Ghaydaa Juma Kullab ◽  
Abdul Rehman Z. Zaidi ◽  
Sultan Albaqmi ◽  
Haya Alajlan ◽  
Mohammed Abdullah Alsheef
Keyword(s):  
Venous Thromboembolism ◽  
Blood Group ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Blood Groups ◽  
Blood Type ◽  
Care Hospital ◽  
Abo Blood Groups ◽  
Blood Types ◽  
Obesity Status

Background: ABO blood types are scientifically proved to be associated with the risk of venous thromboembolism (VTE), but data is lacking in the Saudi population. Aims: We aimed to investigate the association between ABO blood types and VTE, to explore potential interactions between ABO blood type with sex and obesity status. Methods: This was a retrospective study with a total of 998 patients, who were admitted with venous thromboembolism at our tertiary care hospital, between January 2010 and January 2018. Demographic and clinical data were collected. We used chi-square tests to assess the association between ABO blood group and the development of VTE. It was decided that the test will be considered significant if the p-value is <0.05. Results: Out of 998 VTE patients, 506 of patients were excluded, because their ABO blood group was not tested. Therefore, 492 patients were qualified as study subjects, of whom 66% of patients had DVT, 23% of patients had pulmonary embolism. Most of them had provoked VTE. Female patients constituted the majority of the study subjects (82.5%). Sample distribution appeared that O blood group was present in 34.1% of all VTE patients, while non-O-blood groups were present in 66% of them. Overall, there was a non-significant difference between VTE in patients with non-O blood type compared to O blood type (p=0.268). Conclusions: Non-O-blood groups (A, B, AB) are the most common blood types in Saudi patients with VTE. There is no statistically significant association between ABO blood groups, gender, and obesity status. Disclosures No relevant conflicts of interest to declare.

scholarly journals Relation of ABO Blood Groups to the Plaque Characteristic of Coronary Atherosclerosis

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Xingtao Huang ◽  
Yongpeng Zou ◽  
Lulu Li ◽  
Shuyuan Chen ◽  
Jingbo Hou ◽  
...  
Keyword(s):  
Blood Group ◽  
Plaque Rupture ◽  
Morphological Characteristics ◽  
Coronary Plaque ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Groups ◽  
Blood Types ◽  
Coronary Syndrome ◽  
Fibrous Cap

The ABO blood types related to morphological characteristics of atherosclerosis plaque are not clear. We aimed to evaluate the relationship between ABO blood groups and the coronary plaque characteristic. We retrospectively identified the target lesions in 392 acute coronary syndrome patients who underwent optical coherence tomography examination before stenting. Subjects were divided into different groups according to different blood types. The fibrous cap thickness was significantly thicker in O type compared with non-O type (0.075±0.033 mm versus0.061±0.024,p<0.001). Meanwhile, the incidence of thin-cap fibroatheroma was also significantly higher in O type compared with non-O type (51.0% versus 71.5%,p<0.001). The O type showed a significantly larger minimum lumen area[1.26 (0.82, 2.13) versus 1.05 (0.67, 1.82),p=0.020]and minimum lumen diameter[1.03 (0.74, 1.31) versus 0.95 (0.66, 1.25),p=0.039]compared with non-O type. There were no differences found in incidence of lipid plaque, plaque rupture, and thrombus between different blood type groups even between O type and non-O type group (p>0.05). The plaques of O type blood group were exhibited more stably compared with non-O type blood group. Moreover, the non-O type blood group have more serious coronary artery stenosis than O type blood group.

scholarly journals ABO blood group system and occurrence of ischemic stroke

2021 ◽  
Author(s):  
Rafaella Chiodini LOTZ ◽  
Carolina da Silveira WELTER ◽  
Silvia Aparecida RAMOS ◽  
Leslie Ecker FERREIRA ◽  
Norberto Luiz CABRAL ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Blood Group ◽  
Cerebrovascular Diseases ◽  
Blood Groups ◽  
Blood Type ◽  
Control Group ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Abo Blood Groups ◽  
Group System

ABSTRACT Background: Ischemic stroke (IS) is a multifactorial disease that presents high rates of morbimortality in Brazil. Several studies proved that there is a link between the ABO blood group system and the occurrence of thrombotic events. Nonetheless, its association with IS is not well established. Objective: For that reason, the purpose hereof was to investigate the relation between the ABO blood groups and the occurrence of IS in a Brazilian cohort of cerebrovascular diseases. Methods: Five hundred and twenty-nine subjects were included over 12 months, from which 275 presented an IS episode and 254 composed the control group. Blood samples were drawn for direct and reverse serotyping. The control and IS groups were compared regarding the traditional risk factors and the distribution of the ABO blood groups. Results: The IS group presented a higher prevalence of systemic arterial hypertension (SAH), diabetes mellitus, smoking habits, family history, cardiopathy, and sedentary lifestyle in comparison with the control group. The AB blood type prevailed among the patients (5.1 vs. 1.6%; p<0.05) and this group had more SAH cases in comparison with the O type group (92.9 vs. 67.3%; p<0.05). Conclusions: Our results suggest that the occurrence of IS is more frequent among patients of the AB blood type.

ABO blood group and the risk of lung cancer: Multicenter, case-control, observational study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1596-1596
Author(s):  
Gungor Utkan ◽  
Yuksel Urun ◽  
Ayten Kayi Cangir ◽  
Omur Berna Oksuzoglu ◽  
Nuriye Özdemir ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Group ◽  
Clinical Features ◽  
Blood Type ◽  
Control Group ◽  
Abo Blood Group ◽  
Significant Difference ◽  
Abo Blood Type ◽  
Relationship Of

1596 Background: The role of genetic factors in the development of cancer is widely accepted. Previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in lung cancer is limited. Methods: All patients who had Lung cancer (LC) and treated between 2000-2011 at the involved centers with defined ABO/Rh were included in our retrospective reviews of tumor registry records. A group of volunteer healthy blood donors of Turkish Red Crescent between 2004 and 2011 were identified as a control group. The relationship of ABO/Rh with clinical features such as age at diagnosis, histological subtype and sex were evaluated. We compared the distributions of ABO/Rh among 1954 patients and 3,022,883 controls. Among LC patients, differences between each of aforementioned ABO/Rh groups with respect to various clinical features were explored, respectively. Results: Of these patients the median age was 62 (range: 17-90). The 84% of patients were male. Overall distributions of ABO blood groups as well as Rh factor were statistically different between patients (43.6% A, 8.3% AB, 17.3% B, 30.8% O, and 86.3% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0,03). In addition, there were statistically significant differences between patients and controls with respect to O vs. nonO (p=0.004) and marginal significance for A vs. nonA (p=0,065), B vs. nonB (p=0,076), and Rh+ vs. Rh- (p=0,057). Among patients, there weren’t statistically significant differences between blood group with respect to sex and age. However there was statistically significant difference between blood group with respect to histology (p=0,001). Although the distribution of A and O were similar according to histology, patients with squamous histology had antigen B more frequently than other histological sub types (p=0,009). Conclusions: In the study populations, ABO blood type was statistically significantly associated with the LC and having blood type other than O increases the risk of LC. Further studies are necessary to define the mechanisms by which ABO blood type may influence breast cancer risk.

scholarly journals Prognostic role of ABO blood group and Rhesus factor in cirrhotic patients with hepatocellular carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alihan Oral ◽  
Tolga Sahin
Keyword(s):  
Hepatocellular Carcinoma ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Rhesus Factor ◽  
Significant Difference ◽  
B Virus ◽  
Cirrhotic Patients

AbstractHepatocellular carcinoma (HCC) is one of the most common types of cancer worldwide. There are many factors in the etiology of HCC such as hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol, obesity, smoking and aflatoxin. Many types of cancer are assumed to be associated with ABO blood group and Rhesus factor (RH). In this study we aimed to evaluate the relationship between tumor characteristics and overall survival (OS), ABO blood group and RH factor in patients with HCC. A total of 507 patients with chronic liver disease (252 patients with HCC and 255 patients without HCC) were included in the study. All demographic, clinic and laboratory (biochemical parameters and blood type) features were collected retrospectively. The mean age of the patients was 54.50 ± 9.30. There was no significant difference in both ABO groups and RH factors between the two groups. We found that vascular invasion rate of the tumor was higher in the B blood group and multicentric localization of tumor was significantly higer in patients with positive RH but there was no difference between OS in ABO and RH blood groups. In addition, the tumor was less multicentric in the AB blood group. Blood groups and RH factor can be used to predict the prognosis in cirrhotic patients with HCC.

scholarly journals Distribution of ABO Blood Groups and Their Association With Low Risk of Severe COVID-19 Infection in Patients

2021 ◽  
Author(s):  
Minfei Peng ◽  
Shigao Huang ◽  
Qingqing Lv ◽  
Chaochao Chen ◽  
Jiajia Qin ◽  
...  
Keyword(s):  
Blood Group ◽  
Lower Risk ◽  
Infection Risk ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Susceptible Population ◽  
Blood Types ◽  
And Gender ◽  
Group Distribution

Abstract Background: To date, only few studies have focused on the correlation between ABO blood groups and COVID-19 infection risk, especially gender differences in infection risk. Our study aimed to describe the ABO blood group distribution and its association with risk of severe COVID-19 infection for effective identification of the susceptible population. Method：From January 21 to February 20, 2020, we compared the ABO blood group distribution and gender distribution and performed a correlation analysis in severe, non-severe, and non-COVID-19 patients. Results The results showed that the laboratory indices were significantly different between blood type O and non-blood-type-O COVID-19 patients. This indicated that patients of the type O blood group had a relatively lower risk of severe COVID-19 infection than patients of other blood types; in particular, females with blood type O had a lower risk of severe COVID-19 infection than males. Conclusion: Herein, we report a potentially simple prediction decision system to minimize the risk of severe COVID-19 infection based on blood type. Special attention should be paid to patients with blood types other than type O to minimize their risk of severe COVID-19 infection.

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