Abstract 3815: Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogues in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action

2012 ◽  
Author(s):  
Noemi Kedei ◽  
Andrea Telek ◽  
Aleksandra M. Michalowski ◽  
Matthew B. Kraft ◽  
Wei Li ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Phorbol Ester ◽  
Mechanism Of Action ◽  
Transcriptional Response ◽  
Cancer Cell Lines ◽  
Bryostatin 1 ◽  
Differential Mechanism ◽  
Insight Into

Yondelis® (ET-743, Trabectedin) sensitizes cancer cell lines to CD95-mediated cell death: New molecular insight into the mechanism of action

2011 ◽  
Vol 658 (2-3) ◽  
pp. 57-64 ◽  
Author(s):  
Jordi Martínez-Serra ◽  
Elena Maffiotte ◽  
Javier Martín ◽  
Teresa Bex ◽  
María Navarro-Palou ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Lines ◽  
Cancer Cell ◽  
Mechanism Of Action ◽  
Cancer Cell Lines ◽  
Insight Into

scholarly journals Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents

2017 ◽  
Vol 16 ◽  
pp. 117693511774725 ◽  
Author(s):  
Julia Krushkal ◽  
Yingdong Zhao ◽  
Curtis Hose ◽  
Anne Monks ◽  
James H Doroshow ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Drug Targeting ◽  
Time Course ◽  
Antitumor Agents ◽  
Transcriptional Response ◽  
Cancer Cell Lines ◽  
Expression Data ◽  
Cancer Pathways ◽  
Genes Encoding

Cellular glycosylation processes are vital to cell functioning. In malignant cells, they are profoundly altered. We used time-course gene expression data from the NCI-60 cancer cell lines treated with 11 antitumor agents to analyze expression changes of genes involved in glycosylation pathways, genes encoding glycosylation targets or regulators, and members of cancer pathways affected by glycosylation. We also identified glycosylation genes for which pretreatment expression levels or changes after treatment were correlated with drug sensitivity. Their products are involved in N-glycosylation and O-glycosylation, fucosylation, biosynthesis of poly- N-acetyllactosamine, removal of misfolded proteins, binding to hyaluronic acid and other glycans, and cell adhesion. Tumor cell sensitivity to multiple agents was correlated with transcriptional response of C1GALT1C1, FUCA1, SDC1, MUC1; members of the MGAT, GALNT, B4GALT, B3GNT, MAN, and EDEM families; and other genes. These genes may be considered as potential candidates for drug targeting in combination therapy to enhance treatment response.

scholarly journals Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action

MedChemComm ◽  
2016 ◽  
Vol 7 (3) ◽  
pp. 550-561 ◽  
Author(s):  
Mireia Quintana ◽  
Juan V. Alegre-Requena ◽  
Eugenia Marqués-López ◽  
Raquel P. Herrera ◽  
Gemma Triola
Keyword(s):  
Gastric Carcinoma ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Mechanism Of Action ◽  
Cancer Cell Lines ◽  
Carcinoma Cells ◽  
Human Gastric Carcinoma ◽  
Human Gastric Carcinoma Cells

A series of squaramates and squaramides have been synthesized and their cytotoxic activity has been investigated in different cancer cell lines.

The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines

2004 ◽  
Vol 98 (10) ◽  
pp. 1614-1624 ◽  
Author(s):  
Matthew D. Hall ◽  
Shahriar Amjadi ◽  
Mei Zhang ◽  
Philip J. Beale ◽  
Trevor W. Hambley
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Mechanism Of Action ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Ovarian Cancer Cell Lines

Mechanism of action of salinomycin on growth and migration in pancreatic cancer cell lines

Pancreatology ◽  
2013 ◽  
Vol 13 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Lei He ◽  
Fan Wang ◽  
Wei-Qi Dai ◽  
Dong Wu ◽  
Chun-Lei Lin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Mechanism Of Action ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
And Migration
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