Abstract LB-132: The potential role of the multienzyme aminoacyl-tRNA synthetase complex in Th-1 immunity: implications for cancer immunotherapy

2012 ◽  
Author(s):  
Matthew M. Halpert ◽  
David Spencer ◽  
Ratan Bhardwaj ◽  
Michael E. Berens ◽  
William K. Decker
Keyword(s):  
Cancer Immunotherapy ◽  
Potential Role ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
Th 1

scholarly journals ABNORMAL NAILFOLD VIDEOCAPILLAROSCOPY IN PATIENTS WITH ANTISYNTHETASE SYNDROME: CASE REPORTS AND REVIEW OF THE LITERATURE

2017 ◽  
Vol 26 (2) ◽  
pp. 65-70
Author(s):  
Cristina Pomirleanu ◽  
◽  
Georgiana Strugariu ◽  
Iulian Resmerita ◽  
Andreea Axinte ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Case Reports ◽  
Trna Synthetase ◽  
Review Of The Literature ◽  
Aminoacyl Trna Synthetase ◽  
Nailfold Videocapillaroscopy ◽  
Disease Subtype ◽  
Distinct Subset ◽  
Decisional Algorithm

Classified as a distinct subset of idiopathic inflammatory myopathies, anti-synthetase syndrome is an orphan autoimmune disease characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies associated with a spectrum of clinical features including interstitial lung disease, myositis or dermatomyositis, chronic polyarthritis, fever, mechanic‘s hands and Raynaud‘s phenomenon. The main objective of our study was to evaluate nailfold capillary abnormalities in a series of cases diagnosed with anti-synthetase syndrome, aiming to describe capillaroscopy findings and to identify potential relation with clinical and functional outcomes. Irrespective of clinical and serological disease subtype, significant capillaroscopic changes may help diagnosis and identify negative prognostic factors, advancing the role of routine capillaroscopy in the decisional algorithm of anti-synthetase syndrome. Nailfold videocapillaroscopy is able to provide valuable information in patients with anti-tRNA synthetase myositis, suggesting that diffuse microangiopathy represents an early pathobiologic event.

scholarly journals Potential Role of CD47-Directed Bispecific Antibodies in Cancer Immunotherapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Yang ◽  
Zheng Yang ◽  
Yun Yang
Keyword(s):  
Cancer Immunotherapy ◽  
Potential Role ◽  
Bispecific Antibody ◽  
Lymphoblastic Leukemia ◽  
Bispecific Antibodies ◽  
The Novel ◽  
Mechanisms Of Resistance ◽  
Immunological Therapy ◽  
Novel Targets

The prosperity of immunological therapy for cancer has aroused enormous passion for exploiting the novel targets of cancer immunotherapy. After the approval of blinatumomab, a bispecific antibody (bsAb) targeting on CD19 for acute lymphoblastic leukemia, a few of CD47-targeted bsAbs for cancer immunotherapy, are currently in clinical research. In our review of CD47-targeted bsAbs, we described the fundamental of bsAbs. Then, we summarized the information of four undergoing phase I researches, reviewed the main toxicities relevant to CD47-targeted bsAb immunological therapy of on-target cytotoxicity to healthy cells and a remarkable antigen-sink. Finally, we described possible mechanisms of resistance to CD47-targeted bsAb therapy. More clinical researches are supposed to adequately confirm its security and efficacy in clinical practice.

scholarly journals The potential role of vitamin C in empowering cancer immunotherapy

2022 ◽  
Vol 146 ◽  
pp. 112553
Author(s):  
Takwa Bedhiafi ◽  
Varghese Philipose Inchakalody ◽  
Queenie Fernandes ◽  
Sarra Mestiri ◽  
Nashiru Billa ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cancer Immunotherapy ◽  
Potential Role

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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