Abstract 5194: Development of a cytotoxic fusion protein targeting VEGF receptors with improved cytotoxicity, stability and pharmacokinetics

2020 ◽  
Author(s):  
Khalid A. Mohamedali ◽  
Lawrence H. Cheung ◽  
Ana A. Alvarez-Cienfuegos ◽  
Michael G. Rosenblum
Keyword(s):  
Fusion Protein ◽  
Protein Targeting ◽  
Vegf Receptors

scholarly journals Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1

2013 ◽  
Vol 27 (1) ◽  
pp. 220-231 ◽  
Author(s):  
Tracy R. Daniels-Wells ◽  
Gustavo Helguera ◽  
José A. Rodríguez ◽  
Lai Sum Leoh ◽  
Michael A. Erb ◽  
...  
Keyword(s):  
Cell Death ◽  
Fusion Protein ◽  
Cancer Cells ◽  
Transferrin Receptor ◽  
Protein Targeting ◽  
Transferrin Receptor 1 ◽  
Antibody Fusion Protein

Results from a second-line (2L) NSCLC cohort treated with M7824 (MSB0011359C), a bifunctional fusion protein targeting TGF-β and PD-L1.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 9017-9017 ◽  
Author(s):  
Luis G. Paz-Ares ◽  
Tae Min Kim ◽  
David Vicente Baz ◽  
Enriqueta Felip ◽  
Dae Ho Lee ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Protein Targeting ◽  
Second Line ◽  
Bifunctional Fusion Protein

Selection of the recommended phase 2 dose (RP2D) for M7824 (MSB0011359C), a bifunctional fusion protein targeting TGF-β and PD-L1.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 2566-2566 ◽  
Author(s):  
Yulia Vugmeyster ◽  
Justin Wilkins ◽  
Eleanor Harrison-Moench ◽  
Wanping Geng ◽  
Andre Koenig ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Protein Targeting ◽  
Phase 2 ◽  
Bifunctional Fusion Protein ◽  
Selection Of

scholarly journals P17-16. Anti-Langerin-HIV Gag p24 fusion protein targeting Langerhans cells as a new anti-HIV vaccine strategy

Retrovirology ◽  
2009 ◽  
Vol 6 (S3) ◽  
Author(s):  
S Culina ◽  
G Zurawsky ◽  
A Flamar ◽  
P Brochard ◽  
B Delache ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Langerhans Cells ◽  
Protein Targeting ◽  
Hiv Vaccine ◽  
Vaccine Strategy ◽  
Anti Hiv
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