Abstract 2495: SPARC: a bladder cancer tumor-suppressor via targeting metabolic programming

2021 ◽  
Author(s):  
Sameh Waleed Almousa ◽  
Alia Ghoneum ◽  
Hesham Afify ◽  
Neveen Said
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Metabolic Programming ◽  
Cancer Tumor

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

Genomics ◽  
1998 ◽  
Vol 48 (3) ◽  
pp. 277-288 ◽  
Author(s):  
Tomonori Habuchi ◽  
Mike Luscombe ◽  
Patricia A. Elder ◽  
Margaret A. Knowles
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Cancer Tumor

Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer

2019 ◽  
Vol 24 (39) ◽  
pp. 4605-4610 ◽  
Author(s):  
Atena Soleimani ◽  
Farzad Rahmani ◽  
Gordon A. Ferns ◽  
Mikhail Ryzhikov ◽  
Amir Avan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Suppressor ◽  
Current Knowledge ◽  
Akt Signaling ◽  
Tumor Tissues ◽  
Radio Therapy ◽  
Signaling Axis ◽  
Cancer Tumor ◽  
Novel Biomarkers

Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.

Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer

1999 ◽  
Vol 26 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Hiroyuki Nishiyama ◽  
Takeshi Takahashi ◽  
Yoshiyuki Kakehi ◽  
Tomonori Habuchi ◽  
Margaret A. Knowles
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Homozygous Deletion ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Candidate Tumor Suppressor

scholarly journals MicroRNA-490-5p is a novel tumor suppressor targeting c-FOS in human bladder cancer

2015 ◽  
Vol 3 ◽  
pp. 561-569 ◽  
Author(s):  
Gongbin Lan ◽  
Luoyan Yang ◽  
Xubiao Xie ◽  
Longkai Peng ◽  
Yi Wang
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Human Bladder Cancer ◽  
Human Bladder

miR-7-5p acts as a tumor suppressor in bladder cancer by regulating the hedgehog pathway factor Gli3

2018 ◽  
Vol 503 (3) ◽  
pp. 2101-2107 ◽  
Author(s):  
Jun Li ◽  
Mingxing Qiu ◽  
Yu An ◽  
Jianlin Huang ◽  
Chunyu Gong
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Hedgehog Pathway
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