Abstract CT038: Kinetics of radiographic response for tebentafusp (tebe) in previously treated metastatic uveal melanoma (mUM) patients (pts) achieving prolonged survival

2021 ◽  
Author(s):  
Marcus O. Butler ◽  
Takami Sato ◽  
Richard D. Carvajal ◽  
Joseph J. Sacco ◽  
Shaad E. Abdullah ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Prolonged Survival ◽  
Radiographic Response ◽  
Previously Treated ◽  
Kinetics Of

Phase II study of vincristine sulfate liposomes injection in patients with metastatic uveal melanoma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9067-9067 ◽  
Author(s):  
A. Y. Bedikian ◽  
T. Sato ◽  
K. B. Kim ◽  
N. E. Papadopoulos ◽  
W. Hwu ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Uveal Melanoma ◽  
Single Agent ◽  
Evaluation Criteria ◽  
Stage Iv ◽  
Complete Response ◽  
Pharmacokinetic Studies ◽  
Vincristine Sulfate ◽  
Baseline Serum ◽  
Previously Treated

9067 Background: Preclinical and clinical studies showed that liposomal encapsulation of vincristine sulfate (VCR) results in increased drug circulation time and accumulation of VCR at the tumor site. Marqibo has been administered safely at 2.25 mg/m2, a dose exceeding that typically employed for VCR ( dose capped at 2 mg), with tolerable clinical toxicities consistent with VCR. Of the 27 previously treated patients with metastatic melanoma in the Marqibo pharmacokinetic studies, 3 patients had a tumor response, including one patient with uveal melanoma metastatic to the lung that experienced a complete response. Methods: Patients with metastatic uveal melanoma with no more than one prior systemic therapy were enrolled. Patients with controlled brain metastases were allowed. Marqibo (2.25 mg/m2 by 1-hour intravenous infusion, no dose capping) was administered every 14 days until tumor progression. Responses were assessed every 6 weeks using the Response Evaluation Criteria in Solid Tumors (RECIST). Toxicity was assessed at least as frequently as before each dose. Results: Preliminary data is available for 22 enrolled patients (73% female). Median age was 65 years (range 38–79), 23% were previously treated with systemic chemotherapy, 86% had liver metastasis and 96% had M1c disease. Baseline serum LDH levels were elevated in 73% and were more than 2 × ULN in 37% of the patients. Twenty-one patients were evaluable for response; one patient discontinued the treatment after a single dose of therapy for toxicity without tumor progression. No patients died of drug toxicity while on the study. Twelve patients (57%) had stable disease. Estimated median survival is 6.4 months. Fourteen patients are alive, 2 for more than 12 months. Treatment related side effects were mostly grade 1 or 2; peripheral neuropathy was the only grade 3 toxicity, seen in 18% of the patients. The hematologic toxicities were minor; no neutropenia or thrombocytopenia was seen. Conclusions: Marqibo is well tolerated as single agent therapy in patients with advanced stage IV uveal melanoma. Its impact on the progression-free and overall survival of these critically ill patients will be presented. No significant financial relationships to disclose.

The mitotic index in secondary enucleated eyes of previously treated uveal melanoma patients

2012 ◽  
Vol 90 ◽  
pp. 0-0
Author(s):  
S BAKALIAN ◽  
N CASSOUX ◽  
C LEVY ◽  
L LUMBROSO-LE ROUIC ◽  
L DESJARDINS
Keyword(s):  
Mitotic Index ◽  
Uveal Melanoma ◽  
Previously Treated ◽  
Melanoma Patients

scholarly journals Inhibition of microsomal oxidation of ethanol by pyrazole and 4-methylpyrazole in vitro Increased effectiveness after induction by pyrazole and 4-methylpyrazole

1986 ◽  
Vol 239 (3) ◽  
pp. 671-677 ◽  
Author(s):  
D E Feierman ◽  
A I Cederbaum
Keyword(s):  
Alcohol Dehydrogenase ◽  
Ethanol Oxidation ◽  
Liver Microsomes ◽  
Chronic Ethanol ◽  
Ethanol Metabolism ◽  
Ethanol Treatment ◽  
Previously Treated ◽  
Kinetics Of ◽  
Oxidation Of Ethanol

Pyrazole and 4-methylpyrazole, which are inhibitors of alcohol dehydrogenase, were also found to be effective inhibitors of the oxidation of ethanol by liver microsomes (microsomal fractions) in vitro. Ethanol oxidation by microsomes from rats previously treated for 2 or 3 days with either pyrazole or 4-methylpyrazole appeared to be especially sensitive to inhibition in vitro by pyrazole or 4-methylpyrazole. The kinetics of inhibition by pyrazole or 4-methylpyrazole in all microsomal preparations were mixed, as the Km for ethanol was elevated while Vmax was lowered. However, Ki values for pyrazole (about 0.35 mM) and especially 4-methylpyrazole (about 0.03-0.10 mM) were much lower than those found with the saline controls (about 0.7-1.1 mM). In contrast, Ki values for dimethyl sulphoxide as an inhibitor of microsomal ethanol oxidation were similar in all microsomal preparations. Pyrazole and 4-methylpyrazole reacted with microsomes to produce type II spectral changes whose magnitude increased after treatment with either pyrazole or 4-methylpyrazole. Thus the increased inhibitory effectiveness of pyrazole and 4-methylpyrazole appears to be associated with increased interactions with the cytochrome P-450 isoenzyme(s) induced by these compounds. These isoenzymes have properties similar to those of the isoenzyme induced by chronic ethanol treatment. Therefore, caution is needed in the use of pyrazole or 4-methylpyrazole to assess pathways of ethanol metabolism, especially after chronic ethanol treatment, since these agents, besides inhibiting alcohol dehydrogenase, are also effective inhibitors of microsomal ethanol oxidation.

scholarly journals A study on the kinetics of ozone decomposition in waters of different quality

2004 ◽  
Vol 58 (3) ◽  
pp. 118-122 ◽  
Author(s):  
Ljiljana Takic ◽  
Miodrag Lazic ◽  
Vlada Veljkovic ◽  
Srdjan Pejanovic
Keyword(s):  
Reaction Rate ◽  
Tap Water ◽  
Ozone Decomposition ◽  
Distilled Water ◽  
Reaction Rate Constants ◽  
Stirred Reactor ◽  
Different Temperatures ◽  
Previously Treated ◽  
Kinetics Of ◽  
Better Than

The kinetics of ozone decomposition in waters of different quality, namely distilled water, tap water previously treated with ozone, tap water not treated with ozone and raw water from an accumulation lake, were studied in a batch stirred reactor at different temperatures (18-28?C). The dissolved ozone concentration was measured by the iodometric titration method. It was determined that an empirical kinetic equation of the form: dc(O3)/dt= k0 + k1c(O3) fitted the experimental data better than a first-order reaction rate equation. The apparent reaction rate constants in the case of ozone decomposition in distilled water were shown to be a function of temperature in accordance with the Arrhenius equation.

Direct observations of radiation-enhanced transformations in glass

1983 ◽  
Vol 41 ◽  
pp. 354-355
Author(s):  
J. F. DeNatale ◽  
D. G. Howitt
Keyword(s):  
Glass Matrix ◽  
Diffusion Mechanism ◽  
Bubble Formation ◽  
Silicate Glasses ◽  
Phase Decomposition ◽  
Direct Observations ◽  
Thin Foils ◽  
Oxygen Bubble ◽  
Electron Energy Loss ◽  
Kinetics Of

The electron irradiation of silicate glasses containing metal cations produces various types of phase separation and decomposition which includes oxygen bubble formation at intermediate temperatures figure I. The kinetics of bubble formation are too rapid to be accounted for by oxygen diffusion but the behavior is consistent with a cation diffusion mechanism if the amount of oxygen in the bubble is not significantly different from that in the same volume of silicate glass. The formation of oxygen bubbles is often accompanied by precipitation of crystalline phases and/or amorphous phase decomposition in the regions between the bubbles and the detection of differences in oxygen concentration between the bubble and matrix by electron energy loss spectroscopy cannot be discerned (figure 2) even when the bubble occupies the majority of the foil depth.The oxygen bubbles are stable, even in the thin foils, months after irradiation and if van der Waals behavior of the interior gas is assumed an oxygen pressure of about 4000 atmospheres must be sustained for a 100 bubble if the surface tension with the glass matrix is to balance against it at intermediate temperatures.

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