Abstract LB101: Mechanism of the growth inhibitory effect of pemetrexed disodium heptahydrate in human PC9 cells (EGFR exon 19 deletion)

Author(s):  
Md Mohiuddin ◽  
Hideharu Kimura ◽  
Takashi Sone ◽  
Satoshi Watanabe ◽  
Hiroki Matsuoka ◽  
...  
2001 ◽  
Vol 47 (8) ◽  
pp. 735-740 ◽  
Author(s):  
A Rainio ◽  
M Vahvaselkä ◽  
T Suomalainen ◽  
S Laakso

A method for the production of conjugated linoleic acid (CLA) from linoleic acid (LA) using growing cultures of Propionibacterium freudenreichii ssp. shermanii JS was developed. The growth inhibitory effect of LA was eliminated by dispersing it in a sufficient concentration of polyoxyethylene sorbitan monooleate detergent. For the whey permeate medium used, the optimum LA:detergent ratio was 1:15 (w/w). As a result, the cultures tolerated at least 1000 µg·mL–1LA, which was converted to CLA with 57%–87% efficiency. The cis-9, trans-11 and trans-9, cis-11 isomers constituted 85%–90% of the CLA produced. The feasibility of the method was demonstrated also in de Man – Rogosa–Sharpe (MRS) broth.Key words: conjugated linoleic acid, linoleic acid, Propionibacterium freudenreichii ssp. shermanii.


1990 ◽  
Vol 75 (4) ◽  
pp. 489-495 ◽  
Author(s):  
L. M. Larocca ◽  
M. Piantelli ◽  
G. Leone ◽  
S. Sica ◽  
L. Teofili ◽  
...  

Biotherapy ◽  
1991 ◽  
Vol 3 (4) ◽  
pp. 351-357 ◽  
Author(s):  
Kazuhiko Ino ◽  
Setsuko Goto ◽  
Akemi Kosaki ◽  
Seiji Nomura ◽  
Eiko Asada ◽  
...  

1988 ◽  
Vol 31 (4) ◽  
pp. 655-663 ◽  
Author(s):  
C. Chouvet ◽  
E. Vicard ◽  
L. Frappart ◽  
N. Falette ◽  
M.F. Lefebvre ◽  
...  

2014 ◽  
Vol 33 (6) ◽  
pp. 1491-1497 ◽  
Author(s):  
OSAMU NAKAMURA ◽  
TOSHIAKI HITORA ◽  
YOSHIKI YAMAGAMI ◽  
MASAKI MORI ◽  
HIDEKI NISHIMURA ◽  
...  

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