scholarly journals Cryptotanshinone Inhibits Lymphatic Endothelial Cell Tube Formation by Suppressing VEGFR-3/ERK and Small GTPase Pathways

2011 ◽  
Vol 4 (12) ◽  
pp. 2083-2091 ◽  
Author(s):  
Yan Luo ◽  
Wenxing Chen ◽  
Hongyu Zhou ◽  
Lei Liu ◽  
Tao Shen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Tube Formation ◽  
Small Gtpase

scholarly journals Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158408 ◽  
Author(s):  
Akinori Sato ◽  
Ryuta Kamekura ◽  
Koji Kawata ◽  
Masaya Kawada ◽  
Sumito Jitsukawa ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Tube Formation ◽  
Cell Homeostasis

A Three-Dimensional Lymphatic Endothelial Cell Tube Formation Assay to Identify Novel Kinases Involved in Lymphatic Vessel Remodeling

2017 ◽  
Vol 15 (1) ◽  
pp. 30-43 ◽  
Author(s):  
T. Jessica Gambino ◽  
Steven P. Williams ◽  
Carol Caesar ◽  
Daniel Resnick ◽  
Cameron J. Nowell ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Lymphatic Vessel ◽  
Three Dimensional ◽  
Lymphatic Endothelial Cell ◽  
Tube Formation ◽  
Vessel Remodeling ◽  
Tube Formation Assay

scholarly journals WISP-3 Stimulates VEGF-C-Dependent Lymphangiogenesis in Human Chondrosarcoma Cells by Inhibiting miR-196a-3p Synthesis

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1330
Author(s):  
Chih-Yang Lin ◽  
Shih-Wei Wang ◽  
Jeng-Hung Guo ◽  
Huai-Ching Tai ◽  
Wen-Chun Sun ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Bone Tumor ◽  
Cancer Metastasis ◽  
Lymphatic Endothelial Cell ◽  
Metastatic Potential ◽  
Tube Formation ◽  
Malignant Bone Tumor ◽  
Human Chondrosarcoma ◽  
Stimulation Of

Chondrosarcoma is a malignant bone tumor with high metastatic potential. Lymphangiogenesis is a critical biological step in cancer metastasis. WNT1-inducible signaling pathway protein 3 (WISP-3) regulates angiogenesis and facilitates chondrosarcoma metastasis, but the role of WISP-3 in chondrosarcoma lymphangiogenesis is unclear. In this study, incubation of chondrosarcoma cells with WISP-3 increased the production of VEGF-C, an important lymphangiogenic factor. Conditioned medium from WISP-3-treated chondrosarcoma cells significantly enhanced lymphatic endothelial cell tube formation. WISP-3-induced stimulation of VEGF-C-dependent lymphangiogenesis inhibited miR-196a-3p synthesis in the ERK, JNK, and p38 signaling pathways. This evidence suggests that the WISP-3/VEGF-C axis is worth targeting in the treatment of lymphangiogenesis in human chondrosarcoma.

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