Blood Levels of Alpha-1-Antichymotrypsin and Risk Factors for Alzheimer’s Disease: Effects of Gender and Apolipoprotein E Genotype

2000 ◽  
Vol 11 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Federico Licastro ◽  
Eliezer Masliah ◽  
Steve Pedrini ◽  
Leon J. Thal
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Blood Levels ◽  
Apolipoprotein E Genotype

scholarly journals Apolipoprotein E ε4 allele and malondialdehyde level are independent risk factors for Alzheimer’s disease

2016 ◽  
Vol 4 ◽  
pp. 205031211562673 ◽  
Author(s):  
Natividad López-Riquelme ◽  
Jordi Alom-Poveda ◽  
Nuria Viciano-Morote ◽  
Isabel Llinares-Ibor ◽  
Consuelo Tormo-Díaz
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Peroxidation ◽  
Apolipoprotein E ◽  
Serum Lipids ◽  
Ε4 Allele ◽  
Independent Risk Factors ◽  
Polymerase Chain ◽  
Apolipoprotein E Genotype

Background: The ε4 allele of Apolipoprotein E is involved in lipid metabolism. Oxidative stress produces an increase in lipid peroxidation that has been implicated in the pathogenic cascade in Alzheimer’s disease. This study estimated the effect of the ε4 allele, malondialdehyde and lipid levels on the risk for Alzheimer’s disease. Methods: A total of 41 control subjects and 73 patients with Alzheimer’s disease were recruited. The Apolipoprotein E genotype was determined by amplification of exon 4 of the Apolipoprotein E by polymerase chain reaction (PCR); malondialdehyde concentration was determined by high-pressure liquid chromatography, and serum lipids were measured by routine photometric techniques. Results: Malondialdehyde levels were significantly higher in Alzheimer’s disease patients independent of the Apolipoprotein E genotype and ε4 allele. The ε4 allele increases the risk of Alzheimer’s disease by 5.114 times and elevated malondialdehyde levels increase the risk by 9.342. Conclusion: The presence of ε4 allele and elevated malondialdehyde levels are independent risk factors for Alzheimer’s disease. These findings support the hypothesis that lipid peroxidation and ε4 allele contribute to the pathogenic cascade in Alzheimer’s disease by different pathways.

P1-282: Apolipoprotein E genotype in biparietal Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S179-S179
Author(s):  
Jonathan M. Schott ◽  
Basil H. Ridha ◽  
Sebastian J. Crutch ◽  
Elizabeth K. Warrington ◽  
Martin N. Rossor ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype

The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease

2010 ◽  
Vol 25 (5) ◽  
pp. 511-518 ◽  
Author(s):  
Dylan G. Harwood ◽  
Ari Kalechstein ◽  
Warren W. Barker ◽  
Silvia Strauman ◽  
Peter St. George-Hyslop ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Age Of Onset ◽  
Tobacco Consumption ◽  
Apolipoprotein E Genotype

Apolipoprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent

1999 ◽  
Vol 843 (1-2) ◽  
pp. 87-94 ◽  
Author(s):  
Uwe Beffert ◽  
Jeffrey S Cohn ◽  
Caroline Petit-Turcotte ◽  
Michel Tremblay ◽  
Nicole Aumont ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Frontal Cortex ◽  
Β Amyloid ◽  
Apolipoprotein E Genotype

Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy‐verified series

1996 ◽  
Vol 165 (2) ◽  
pp. 77-80 ◽  
Author(s):  
Victoria A Fabian ◽  
Thomas M Jones ◽  
Stephen D Wilton ◽  
Joanne E Dench ◽  
Mark R Davis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Western Australia ◽  
Apolipoprotein E Genotype

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

1999 ◽  
Vol 27 (5-6) ◽  
pp. 544-553 ◽  
Author(s):  
Charles Ramassamy ◽  
Diana Averill ◽  
Uwe Beffert ◽  
Stephane Bastianetto ◽  
Louise Theroux ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Damage ◽  
Apolipoprotein E ◽  
Frontal Cortex ◽  
Apolipoprotein E Genotype
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