Deposition of Mannan Binding Protein and Mannan Binding Protein-Mediated Complement Activation in the Glomeruli of Patients with IgA Nephropathy

Nephron ◽  
1998 ◽  
Vol 80 (4) ◽  
pp. 408-413 ◽  
Author(s):  
Mitsuhiro Matsuda ◽  
Kenichi Shikata ◽  
Jun Wada ◽  
Hikaru Sugimoto ◽  
Yasushi Shikata ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Complement Activation ◽  
Binding Protein

scholarly journals The mechanism of carbohydrate-mediated complement activation by the serum mannan-binding protein.

1990 ◽  
Vol 265 (4) ◽  
pp. 1980-1984 ◽  
Author(s):  
M Ohta ◽  
M Okada ◽  
I Yamashina ◽  
T Kawasaki
Keyword(s):  
Complement Activation ◽  
Binding Protein

Vitamin D-Binding Protein Is a Potential Urinary Biomarker of Irbesartan Treatment Response in Patients with IgA Nephropathy

2016 ◽  
Vol 20 (11) ◽  
pp. 666-673
Author(s):  
Jiashun Zeng ◽  
Qiong Wen ◽  
Rong Rong ◽  
Fengxian Huang ◽  
Qiongqiong Yang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Treatment Response ◽  
Iga Nephropathy ◽  
Binding Protein ◽  
Urinary Biomarker ◽  
Vitamin D Binding Protein

scholarly journals Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation

2011 ◽  
Vol 187 (1) ◽  
pp. 424-433 ◽  
Author(s):  
Panisadee Avirutnan ◽  
Richard E. Hauhart ◽  
Pawit Somnuke ◽  
Anna M. Blom ◽  
Michael S. Diamond ◽  
...  
Keyword(s):  
Complement Activation ◽  
Nonstructural Protein ◽  
Binding Protein

scholarly journals Complement activation in experimental IgA nephropathy: An antigen-mediated process

1987 ◽  
Vol 32 (6) ◽  
pp. 838-844 ◽  
Author(s):  
Abdalla Rifai ◽  
Ann Chen ◽  
Hirokazu Imai
Keyword(s):  
Iga Nephropathy ◽  
Complement Activation

C4BPAL1, a Member of the Human Regulator of Complement Activation (RCA) Gene Cluster That Resulted from the Duplication of the Gene Coding for the α-Chain of C4b-Binding Protein

Genomics ◽  
1993 ◽  
Vol 17 (1) ◽  
pp. 185-193 ◽  
Author(s):  
Pilar Sánchez-Corral ◽  
Fernando Pardo-Manuel de Villena ◽  
Javier Rey-Campos ◽  
Santiago Rodrı́guez de Córdoba
Keyword(s):  
Gene Cluster ◽  
Complement Activation ◽  
Binding Protein ◽  
Gene Coding ◽  
Α Chain

Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S–C4b binding protein complex

Blood ◽  
2004 ◽  
Vol 103 (4) ◽  
pp. 1192-1201 ◽  
Author(s):  
Suely Meireles Rezende ◽  
Rachel Elizabeth Simmonds ◽  
David Anthony Lane
Keyword(s):  
Venous Thromboembolism ◽  
Complement Activation ◽  
Protein C ◽  
Binding Protein ◽  
Anticoagulant Activity ◽  
Activated Protein C ◽  
Protein S ◽  
Increased Risk ◽  
Established Role ◽  
Structure And Functions

AbstractProtein S (PS) has an established role as an important cofactor to activated protein C (APC) in the degradation of coagulation cofactors Va and VIIIa. This anticoagulant role is evident from the consequences of its deficiency, when there is an increased risk of venous thromboembolism. In human plasma, PS circulates approximately 40% as free PS (FPS) and 60% in complex with C4b-binding protein (C4BP). Formation of this complex results in loss of PS cofactor function, and C4BP can then modulate the anticoagulant activity of APC. It had long been predicted that the complex could act as a bridge between coagulation and inflammation due to the involvement of C4BP in regulating complement activation. This prediction was recently supported by the demonstration of binding of the PS-C4BP complex to apoptotic cells. This review aims to summarize recent findings on the structure and functions of PS, the basis and importance of its deficiency, its interaction with C4BP, and the possible physiologic and pathologic importance of the PS-C4BP interaction.

Regulation of complement activation by C-reactive protein: Targeting of the inhibitory activity of C4b-binding protein

2007 ◽  
Vol 44 (1-3) ◽  
pp. 241
Author(s):  
Andreas P. Sjöberg ◽  
Leendert A. Trouw ◽  
Fabian McGrath ◽  
C. Erik Hack ◽  
Anna Blom
Keyword(s):  
Complement Activation ◽  
Inhibitory Activity ◽  
Protein Targeting ◽  
Binding Protein ◽  
C Reactive Protein ◽  
Reactive Protein
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