Dermoscopic Features of Plaque Psoriasis and Lichen Planus: New Observations

Plaque psoriasis (PSO) and lichen planus (LP) are skin diseases with some similarities in pathogenesis, comorbidities, and clinical presentation. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and its ligand, α4β7 integrin, are involved in inflammatory bowel diseases and liver dysfunctions, which occur more frequently in PSO and LP. Serum MAdCAM-1 and ITGB7 levels in patients with plaque PSO and eruptive LP have never been studied before. The study included 42 patients with PSO, 13 with LP, and 23 controls. Serum molecules levels were evaluated using the immune–enzymatic method. ITGB7 concentration was not statistically different, both in patients with PSO and LP, compared to controls (both p > 0.05). MAdCAM-1 level was significantly lower in PSO subjects than in controls (p = 0.041), whereas in the LP group, a downward trend was observed (p = 0.088) with p = 0.0455 in ANOVA. Multiple linear regression revealed independent associations between ITGB7 and HDL and BMI and RBC in the LP group. In psoriatic patients with elevated CRP, there was an upward trend for MAdCAM-1, and also a positive correlation between MAdCAM-1 and WBC. ITGB7 and MAdCAM-1 cannot serve as markers of disease activity or liver pathology neither in patients with PSO nor LP. MAdCAM-1 might play a role as an inflammation indicator in PSO and a beneficial influence on the lipid profile in LP.

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Exacerbation of generalized plaque psoriasis after tuberculin test

Dermatology Reports ◽

10.4081/dr.2021.9019 ◽

2021 ◽

Author(s):

Alberto Corrà ◽

Lavinia Quintarelli ◽

Alice Verdelli ◽

Walter Volpi ◽

Marzia Caproni

Keyword(s):

Lichen Planus ◽

Plaque Psoriasis ◽

Tuberculin Test ◽

Skin Lesions ◽

Psoriatic Patient ◽

Mantoux Test ◽

Koebner Phenomenon ◽

Dermatological Diseases

Koebner phenomenon, also known as isomorphic response, is the appearance of active skin lesions in sites of epidermal injury. This manifestation is characteristic of different dermatological diseases, such as lichen planus, vitiligo and psoriasis. We present the case of a psoriatic patient who experienced Koebner phenomenon after Mantoux test, followed by eruption of generalized plaque psoriasis.

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Studying of the interleukin-36γ expression level in the skin of patients with plaque psoriasis

Vestnik dermatologii i venerologii ◽

10.25208/0042-4609-2019-95-4-31-39 ◽

2019 ◽

Vol 95 (4) ◽

pp. 31-39 ◽

Cited By ~ 1

Author(s):

A. Yu. Pashkin ◽

A. S. Zhukov ◽

V. R. Khairutdinov ◽

I. E. Belousova ◽

A. V. Samtsov ◽

...

Keyword(s):

Mycosis Fungoides ◽

Lichen Planus ◽

Plaque Psoriasis ◽

Direct Relationship ◽

Skin Diseases ◽

Comparison Group ◽

Healthy People ◽

Expression Level ◽

Control Group ◽

Biopsy Specimens

Currently, it has been established that the cytokines of the IL-36 family occupy a significant place in the initiation and regulation of the inflammatory process in psoriasis.Objective: studying the expression level of IL-36γ cytokines in the skin of patients with plaque psoriasis.Material and methods. Skin biopsy specimens of 31 patients with plaque psoriasis were studied. The comparison group consisted of 20 biopsy samples of the skin of patients with lichen simplex, discoid eczema, lichen planus, mycosis fungoides (plaque stage). As a control group studied the skin bioptates of 10 healthy people. An immunohistochemical study of the skin was carried out using anti-IL-36γ antibodies.Results. An increase in the relative expression area of IL-36γ in the affected skin of patients with plaque psoriasis (7.4 %) was found, compared with the unaffected areas (0.10 %) and the control group (0 %). The expression of IL-36γ in the skin of patients with psoriasis in the progressive period (8.85 %) was 1.42 times higher than in the stationary period of the disease (6.2 %). A strong direct relationship was revealed (r = 0.71) between the level of IL-36γ expression in the affected skin and the value of the PASI index, a moderate direct relationship between the level of IL-36γ expression and epidermal thickness (r = 0.34). In the affected skin of psoriasis patients, expressed expression of IL-36γ was observed in the upper layers of the epidermis, patients of the comparison group (discoid eczema, lichen simplex, lichen planus, mycosis fungoides) were weak or moderate, in the unaffected areas of the skin of patients with psoriasis and healthy people — weak or absent.Findings. It was found that the expression of IL-36γ in the skin of patients with plaque psoriasis is significantly higher than with other skin diseases. The data obtained allow us to consider this cytokine as a possible diagnostic marker and use it in the differential diagnosis.

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