Thrombin Inhibitor, Argatroban, Prevents Tumor Cell Migration and Bone Metastasis

Oncology ◽  
2004 ◽  
Vol 67 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Kunihiro Asanuma ◽  
Hiroki Wakabayashi ◽  
Tatsuya Hayashi ◽  
Noritaka Okuyama ◽  
Masashi Seto ◽  
...  
Keyword(s):  
Cell Migration ◽  
Bone Metastasis ◽  
Tumor Cell ◽  
Thrombin Inhibitor ◽  
Tumor Cell Migration

scholarly journals Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth

2021 ◽  
Vol 7 (22) ◽  
pp. eabb5943
Author(s):  
Fei Li ◽  
Xufei Du ◽  
Fen Lan ◽  
Na Li ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Bone Metastasis ◽  
Tumor Cell ◽  
Cancer Metastasis ◽  
Inflammatory Diseases ◽  
Metastatic Tumor ◽  
Eosinophil Infiltration ◽  
Tumor Cell Migration ◽  
Promote Tumor Cell ◽  
Chemokine Ligand

Compelling evidence suggests that inflammatory components contribute to cancer development. However, eosinophils, involved in several inflammatory diseases, were not fully explored in cancer metastasis. We show that airway inflammatory eosinophilia and colonic inflammation with eosinophil infiltration are both associated with increased metastasis in mice. Eosinophilia is responsible for increased bone metastasis in eosinophil-enriched Cd3δ-Il-5 transgenic (Il-5 Tg) mice. We also observe increased eosinophils in the malignant pleural effusion of cancer patients with pleural metastasis. Mechanistically, eosinophils promote tumor cell migration and metastasis formation through secreting C-C motif chemokine ligand 6 (CCL6). Genetic knockout of Ccl6 in Il-5 Tg mice remarkably attenuates bone metastasis. Moreover, inhibition of C-C chemokine receptor 1 (CCR1, the receptor of CCL6) in tumor cells reduces tumor cell migration and metastasis. Thus, our study identifies a CCL6-dependent prometastatic activity of eosinophils, which can be inhibited by targeting CCR1 and represent an approach to preventing metastatic disease.

In vitro Tumor Cell Migration Assay Using ThinCertsTM (Transwells)

BIO-PROTOCOL ◽  
2016 ◽  
Vol 6 (11) ◽  
Author(s):  
Marc Schneider
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Cell Migration Assay ◽  
Migration Assay ◽  
Tumor Cell Migration

The peptide mimicking small extracellular ring domain of CD82 inhibits tumor cell migration in vitro and metastasis in vivo

2021 ◽  
Author(s):  
Xin He ◽  
Xiaoguang Ma ◽  
Congcong Wang ◽  
Mingchun Luan ◽  
Ying Li ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Ring Domain ◽  
Tumor Cell Migration

scholarly journals Compensation mechanism in tumor cell migration

2003 ◽  
Vol 160 (2) ◽  
pp. 267-277 ◽  
Author(s):  
Katarina Wolf ◽  
Irina Mazo ◽  
Harry Leung ◽  
Katharina Engelke ◽  
Ulrich H. von Andrian ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Shape Change ◽  
Proteolytic Degradation ◽  
Amoeboid Movement ◽  
Tumor Cell Migration ◽  
Tumor Dissemination ◽  
Β1 Integrins

Invasive tumor dissemination in vitro and in vivo involves the proteolytic degradation of ECM barriers. This process, however, is only incompletely attenuated by protease inhibitor–based treatment, suggesting the existence of migratory compensation strategies. In three-dimensional collagen matrices, spindle-shaped proteolytically potent HT-1080 fibrosarcoma and MDA-MB-231 carcinoma cells exhibited a constitutive mesenchymal-type movement including the coclustering of β1 integrins and MT1–matrix metalloproteinase (MMP) at fiber bindings sites and the generation of tube-like proteolytic degradation tracks. Near-total inhibition of MMPs, serine proteases, cathepsins, and other proteases, however, induced a conversion toward spherical morphology at near undiminished migration rates. Sustained protease-independent migration resulted from a flexible amoeba-like shape change, i.e., propulsive squeezing through preexisting matrix gaps and formation of constriction rings in the absence of matrix degradation, concomitant loss of clustered β1 integrins and MT1-MMP from fiber binding sites, and a diffuse cortical distribution of the actin cytoskeleton. Acquisition of protease-independent amoeboid dissemination was confirmed for HT-1080 cells injected into the mouse dermis monitored by intravital multiphoton microscopy. In conclusion, the transition from proteolytic mesenchymal toward nonproteolytic amoeboid movement highlights a supramolecular plasticity mechanism in cell migration and further represents a putative escape mechanism in tumor cell dissemination after abrogation of pericellular proteolysis.

scholarly journals Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors

Gene Therapy ◽  
1999 ◽  
Vol 6 (2) ◽  
pp. 227-236 ◽  
Author(s):  
M Praus ◽  
K Wauterickx ◽  
D Collen ◽  
R D Gerard
Keyword(s):  
Cell Migration ◽  
Gene Transfer ◽  
Tumor Cell ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitors ◽  
Adenoviral Gene Transfer ◽  
Tumor Cell Migration

scholarly journals PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer

2015 ◽  
Vol 48 (2) ◽  
pp. 471-484 ◽  
Author(s):  
LI-XU YAN ◽  
YAN-HUI LIU ◽  
JIAN-WEN XIANG ◽  
QI-NIAN WU ◽  
LEI-BO XU ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Clinical Outcome ◽  
Tumor Cell ◽  
Akt Signaling ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

2008 ◽  
Vol 68 (20) ◽  
pp. 8210-8220 ◽  
Author(s):  
Bharat Joshi ◽  
Scott S. Strugnell ◽  
Jacky G. Goetz ◽  
Liliana D. Kojic ◽  
Michael E. Cox ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Focal Adhesion ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Caveolin 1

GNAI3 inhibits tumor cell migration and invasion and is post-transcriptionally regulated by miR-222 in hepatocellular carcinoma

2015 ◽  
Vol 356 (2) ◽  
pp. 978-984 ◽  
Author(s):  
Yu Zhang ◽  
Jian Yao ◽  
Lin Huan ◽  
Junwei Lian ◽  
Chuanyang Bao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Migration ◽  
Tumor Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration
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