Combined Growth Hormone-Releasing Hormone and Growth Hormone-Releasing Peptide-6 Test for the Evaluation of Growth Hormone Secretion in Children with Growth Hormone Deficiency and Growth Hormone Neurosecretory Dysfunction

2008 ◽  
Vol 70 (4) ◽  
pp. 215-223
Author(s):  
Bessie E. Spiliotis ◽  
Dimitrios T. Papadimitriou ◽  
Theodore K. Alexandrides ◽  
Christoforos Karystianos ◽  
George Nikiforidis ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Hormone Deficiency ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone

Negative correlation between plasma GHRH values and growth velocity in short prepubertal children

1994 ◽  
Vol 141 (3) ◽  
pp. 541-546
Author(s):  
D Evain-Brion ◽  
D Porquet ◽  
A Fjellestad-Paulsen ◽  
M Donnadieu ◽  
M Noel ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Velocity ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Hormone Deficiency ◽  
Growth Hormone Releasing Hormone ◽  
Prepubertal Children ◽  
Releasing Hormone ◽  
Number Of Children ◽  
Short Children

Abstract Numerous data suggest that impaired growth hormone secretion in short children is usually related to abnormal regulation of the hormone at the hypothalamic level. In order to improve our understanding of neurohypothalamic dysfunction in short children, we measured basal and peak (after l–dopa stimulation) plasma growth hormone-releasing hormone levels in 43 prepubertal children. Among them, in 23 children suspected of having hypothalamic growth hormone dysregulation, growth hormone-releasing hormone values were significantly higher than those observed in normal short stature children (n=20), no longer correlated with peak growth hormone following l–dopa, and negatively correlated with growth velocity. This suggests that a predominant inhibitor of growth hormone secretion, such as an increase in somatostatin tone, might be prevalent in a large number of children with partial growth hormone deficiency and suspected hypothalamic growth hormone dysregulation. Journal of Endocrinology (1994) 141, 541–546

Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and l-dopa in obesity

Metabolism ◽  
1990 ◽  
Vol 39 (9) ◽  
pp. 892-896 ◽  
Author(s):  
Katsuaki Tanaka ◽  
Shuji Inoue ◽  
Kazushi Numata ◽  
Hiroshi Okazaki ◽  
Saburo Nakamura ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Weight Reduction ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Growth Hormone Releasing Hormone ◽  
Very Low Calorie Diet ◽  
Releasing Hormone ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

Treatment of radiation‐induced growth hormone deficiency with growth hormone‐releasing hormone

1997 ◽  
Vol 46 (5) ◽  
pp. 571-578 ◽  
Author(s):  
A. L. Ogilvy‐Stuart ◽  
H. F. Stirling ◽  
C. J. H. Kelnar ◽  
M. O. Savage ◽  
D. B. Dunger ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Radiation Induced

Pituitary volume in children with growth hormone deficiency, idiopathic short stature and controls

2016 ◽  
Vol 29 (10) ◽  
Author(s):  
Marion Kessler ◽  
Michael Tenner ◽  
Michael Frey ◽  
Richard Noto
Keyword(s):  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Short Stature ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Magnetic Resonance Images ◽  
Idiopathic Short Stature ◽  
Hormone Deficiency ◽  
Significant Difference

AbstractBackground:The objective of the study was to describe the pituitary volume (PV) in pediatric patients with isolated growth hormone deficiency (IGHD), idiopathic short stature (ISS) and normal controls.Methods:Sixty-nine patients (57 male, 12 female), with a mean age of 11.9 (±2.0), were determined to have IGHD. ISS was identified in 29 patients (20 male, 9 female), with a mean age of 12.7 (±3.7). Sixty-six controls (28 female, 38 male), mean age 9.8 (±4.7) were also included. Three-dimensional (3D) magnetic resonance images with contrast were obtained to accurately measure PV.Results:There was a significant difference in the mean PV among the three groups. The IGHD patients had a mean PV 230.8 (±89.6), for ISS patients it was 286.8 (±108.2) and for controls it was 343.7 (±145.9) (p<0.001). There was a normal increase in PV with age in the ISS patients and controls, but a minimal increase in the IGHD patients.Conclusions:Those patients with isolated GHD have the greatest reduction in PV compared to controls and the patients with ISS fall in between. We speculate that a possible cause for the slowed growth in some ISS patients might be related to diminished chronic secretion of growth hormone over time, albeit having adequate pituitary reserves to respond acutely to GH stimulation. Thus, what was called neurosecretory GHD in the past, might, in some patients, be relative pituitary hypoplasia and resultant diminished growth hormone secretion. Thus, PV determinations by magnetic resonance imaging (MRI) could assist in the diagnostic evaluation of the slowly growing child.

Stimulation and Inhibition of Growth Hormone Secretion by Interleukin-1β; The Involvement of Growth Hormone-Releasing Hormone

1992 ◽  
Vol 56 (1) ◽  
pp. 118-123 ◽  
Author(s):  
Linda C. Payne ◽  
Ferenc Obal, Jr ◽  
Mark R. Opp ◽  
James M. Krueger
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Interleukin 1Β ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Inhibition Of Growth

Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs

1989 ◽  
Vol 256 (2) ◽  
pp. E221-E226 ◽  
Author(s):  
G. D. Snyder ◽  
P. Yadagiri ◽  
J. R. Falck
Keyword(s):  
Growth Hormone ◽  
Arachidonic Acid ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Epoxyeicosatrienoic Acids ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Growth Hormone Releasing Hormone ◽  
Epoxyeicosatrienoic Acid ◽  
Releasing Hormone

Growth hormone secretion was stimulated in vitro by products of arachidonic acid epoxygenase, the epoxyeicosatrienoic acids. 5,6-Epoxyeicosatrienoic and 14,15-epoxyeicosatrienoic acid stimulated growth hormone release from an enriched population of somatotrophs (approximately 85%) by twofold. Inhibition of arachidonic acid metabolism by indomethacin did not affect growth hormone-releasing hormone stimulation of growth hormone release. In contrast, pretreatment of somatotrophs with an 11,12-isonitrile analogue of arachidonic acid that inhibits arachidonic acid epoxygenase, resulted in a 20-25% inhibition of growth hormone-releasing hormone-stimulated growth hormone release. 14,15-Epoxyeicosatrienoic acid stimulated a concentration-dependent increase (twofold) in the cytoplasmic concentration of adenosine 3',5'-cyclic monophosphate (cAMP) in the somatotrophs. 14,15-Epoxyeicosatrienoic acid also rapidly increased the intracellular free calcium concentration in somatotrophs from resting levels (approximately 80 nM) to greater than 250 nM. Growth hormone-releasing hormone increased the free intracellular calcium to 160-180 nM. Preincubation of somatotrophs with somatostatin inhibited growth hormone-releasing hormone-stimulated growth hormone secretion, cAMP accumulation, and 14,15-epoxyeicosatrienoic acid stimulated cAMP accumulation. These data are suggestive that the epoxyeicosatrienoic acids may have a role in the secretion of growth hormone.

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