Regulation of Mouse and Human Mast Cell Development, Survival and Function by Stem Cell Factor, the Ligand for the c-kit Receptor

1995 ◽  
Vol 107 (1-3) ◽  
pp. 51-53 ◽  
Author(s):  
Stephen J. Galli ◽  
Mindy Tsai ◽  
Barry K. Wershil ◽  
See-Ying Tam ◽  
John J. Costa
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Stem Cell Factor ◽  
Cell Development ◽  
Human Mast Cell ◽  
And Function

scholarly journals Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo.

1996 ◽  
Vol 183 (6) ◽  
pp. 2681-2686 ◽  
Author(s):  
J J Costa ◽  
G D Demetri ◽  
T J Harrist ◽  
A M Dvorak ◽  
D F Hayes ◽  
...  
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Mast Cells ◽  
Stem Cell Factor ◽  
Serum Levels ◽  
Human Mast Cell ◽  
Tyrosine Kinase Receptor ◽  
Kit Ligand ◽  
Wheal And Flare

Stem cell factor (SCF), also known as mast cell growth factor, kit ligand, and steel factor, is the ligand for the tyrosine kinase receptor (SCFR) that is encoded by the c-kit proto-oncogene. We analyzed the effects of recombinant human SCF (r-hSCF, 5-50 micrograms/kg/day, injected subcutaneously) on mast cells and melanocytes in a phase I study of 10 patients with advanced breast carcinoma. A wheal and flare reaction developed at each r-hSCF injection site; by electron microscopy, most dermal mast cells at these sites exhibited extensive, anaphylactic-type degranulation. A 14-d course of r-hSCF significantly increased dermal mast cell density at sites distant to those injected with the cytokine and also increased both urinary levels of the major histamine metabolite, methyl-histamine, and serum levels of mast cell alpha-tryptase. Five subjects developed areas of persistent hyperpigmentation at r-hSCF injection sites; by light microscopy, these sites exhibited markedly increased epidermal melanization and increased numbers of melanocytes. The demonstration that r-hSCF can promote both the hyperplasia and the functional activation of human mast cells and melanocytes in vivo has implications for our understanding of the role of endogenous SCF in health and disease. These findings also indicate that the interaction between SCF and its receptor represents a potential therapeutic target for regulating the numbers and functional activity of both mast cells and cutaneous melanocytes.

scholarly journals IL-9 Enhances the Growth of Human Mast Cell Progenitors Under Stimulation with Stem Cell Factor

2003 ◽  
Vol 170 (7) ◽  
pp. 3461-3467 ◽  
Author(s):  
Shigeyuki Matsuzawa ◽  
Kazuo Sakashita ◽  
Tatsuya Kinoshita ◽  
Susumu Ito ◽  
Tetsuji Yamashita ◽  
...  
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Stem Cell Factor ◽  
Human Mast Cell

scholarly journals Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI

2011 ◽  
Vol 127 (3) ◽  
pp. 815-822.e5 ◽  
Author(s):  
Tanya M. Laidlaw ◽  
John W. Steinke ◽  
Adrienne M. Tiñana ◽  
Chunli Feng ◽  
Wei Xing ◽  
...  
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Cell Line ◽  
Stem Cell Factor ◽  
Human Mast Cell ◽  
Mast Cell Line
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