CD24 Gene Allele Variation Is Not Associated with Oligoclonal IgG Bands and IgG Index of Multiple Sclerosis Patients

2012 ◽  
Vol 19 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Mohammad Saadatnia ◽  
Mohammad Reza Najafi ◽  
Faride Najafi ◽  
Vahid Davoudi ◽  
Kiandokht Keyhanian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Igg Index ◽  
Oligoclonal Igg ◽  
Allele Variation ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study

2014 ◽  
Vol 20 (14) ◽  
pp. 1900-1903 ◽  
Author(s):  
R Mancuso ◽  
D Franciotta ◽  
M Rovaris ◽  
D Caputo ◽  
A Sala ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Longitudinal Study ◽  
Retrospective Studies ◽  
Oligoclonal Bands ◽  
Igg Index ◽  
Before And After ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients

Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.

Silver staining of unconcentrated cerebrospinal fluid in agarose gel (Panagel) electrophoresis.

1984 ◽  
Vol 30 (5) ◽  
pp. 735-736 ◽  
Author(s):  
P D Mehta ◽  
S P Mehta ◽  
B A Patrick
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Silver Staining ◽  
Clinical Laboratory ◽  
Neurological Diseases ◽  
Agarose Gel ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Coomassie Brilliant ◽  
Oligoclonal Igg Bands

Abstract We subjected cerebrospinal fluid (CSF) from 20 patients with multiple sclerosis and 20 patients with other neurological diseases to agarose gel ( Panagel ) electrophoresis followed by staining with silver. Ten microliters of unconcentrated CSF from multiple sclerosis patients containing 0.4 to 0.8 microgram of immunoglobulin G was found to be optimum for detection of oligoclonal IgG bands, so identified by immunofixation. The band patterns for unconcentrated CSF stained with silver were almost identical to those for the same CSF concentrated 40-fold and stained with Coomassie Brilliant Blue. Silver staining thus enables the clinical laboratory to electrophorese unconcentrated CSF on commercially prepared ( Panagel ) plates.

scholarly journals Investigation of Oligoclonal IgG Bands in Tear Fluid of Multiple Sclerosis Patients

2019 ◽  
Vol 10 ◽  
Author(s):  
Martin W. Hümmert ◽  
Ulrich Wurster ◽  
Lena Bönig ◽  
Philipp Schwenkenbecher ◽  
Kurt-Wolfram Sühs ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Tear Fluid ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands

2002 ◽  
Vol 8 (6) ◽  
pp. 459-462 ◽  
Author(s):  
I Nakashima ◽  
K Fujihara ◽  
T Misu ◽  
J Fujimori ◽  
S Sato ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Mri ◽  
White Matter Lesions ◽  
Diffuse White Matter ◽  
Mri Features ◽  
Spinal Form ◽  
Magnetic Resonance Imaging Mri ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

The cerebrospinal fluid oligoclonal IgG bands (OB) are less frequently observed in Japanese multiple sclerosis (MS) patients compared with Caucasian patients. We studied 40 consecutive Japanese MS patients to investigate the differences in the clinical and magnetic resonance imaging (MRI) features of MS between OB-positive patients and OB-negative ones. Among the 40 patients, 22 (55%) patients were OB-positive by either agarose gel electrophoresis (AGE) or isoelectric focusing (IEF), and 18 (45%) patients were OB-negative by both AGE and IEF. There were differences between the two groups only in the clinical forms of MS, but not in terms of gender, onset age, disease duration, or disease severity. In the OB-negative group, nine (50%) of the patients had the optic-spinal form of MS (OS-MS), but only one patient (4.5%) in the OB-positive group had OS-MS. Although most OB-positive patients showed brain MRI lesions typical of MS, 13 (72%) of the OB-negative patients showed no or few brain MRI lesions and the rest of the OB-negative patients showed atypical MS lesions, such as diffuse white matter lesions or large ring-enhanced lesions. Our results suggest that the majority of OB-negative Japanese MS patients show either no or few brain MRI lesions or atypical brain MRI lesions.

Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China

2019 ◽  
Vol 66 ◽  
pp. 51-55 ◽  
Author(s):  
Tingting Lu ◽  
Lin Zhao ◽  
Xiaobo Sun ◽  
Cheryl Au ◽  
Yinong Huang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
South China ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

Oligoclonal IgG bands in Japanese multiple sclerosis patients

1999 ◽  
Vol 101 (2) ◽  
pp. 205-206 ◽  
Author(s):  
Ichiro Nakashima ◽  
Kazuo Fujihara ◽  
Yasuto Itoyama
Keyword(s):  
Multiple Sclerosis ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis

2015 ◽  
Vol 21 (9) ◽  
pp. 1112-1120 ◽  
Author(s):  
Masaaki Niino ◽  
Shinya Sato ◽  
Toshiyuki Fukazawa ◽  
Satoshi Yoshimura ◽  
Shin Hisahara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Regression Analysis ◽  
Japanese Patients ◽  
Geographic Region ◽  
Igg Index ◽  
Oligoclonal Igg ◽  
Oligoclonal Igg Bands ◽  
Csf Findings ◽  
Northern Japan

Background: It is unclear whether the prevalence of oligoclonal IgG bands (OCBs) in multiple sclerosis (MS) is different between northern and southern regions of Asia. Objective: This study aimed to compare the prevalence of OCBs and positive cerebrospinal fluid (CSF) findings between northern and southern regions of Japan and to investigate the association of these CSF findings with HLA-DRB1 alleles. Methods: The study included 180 MS patients from Hokkaido (northern Japan) and 184 patients from Kyushu (southern Japan). The IgG index was defined as increased if it was >0.658. Presence of CSF OCBs and/or increased IgG index was defined as positive CSF findings. Results: Positive CSF findings and OCB positivity were significantly higher in MS patients from Hokkaido than in those from Kyushu ( p < 0.0001 for both). Logistic regression analysis revealed that after adjusting for covariates that can be related to abnormal CSF IgG production, the geographic region (Hokkaido) showed odds ratios (ORs) of 4.08 and 2.57, whereas the HLA-DRB1*04:05 allele showed ORs of 0.36 and 0.30 for positive CSF findings and OCB positivity, respectively. Conclusions: The results indicate that latitude and HLA-DRB1 alleles independently affect the emergence of CSF IgG abnormalities in Japanese patients with MS.

Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid are less likely to develop neutralizing antibodies against interferon beta

2010 ◽  
Vol 16 (7) ◽  
pp. 796-800 ◽  
Author(s):  
M. Lundkvist ◽  
E. Greiner ◽  
J. Hillert ◽  
A. Fogdell-Hahn
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
Oligoclonal Bands ◽  
Distinct Subgroup ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Genetically Determined ◽  
Oligoclonal Igg Bands

Multiple sclerosis patients without cerebrospinal fluid oligoclonal IgG bands have been proposed to constitute an immunogenetically distinct subgroup of multiple sclerosis that may also differ in terms of prognosis. A proportion of patients with multiple sclerosis receiving IFNβ develop neutralizing antibodies, which interfere with treatment efficacy. Evidence suggests that the likelihood of developing neutralizing antibodies is partly genetically determined. Here, we hypothesized that absence of oligoclonal IgG bands reflects a property of B-cell responses in oligoclonal IgG band-negative patients characterized by a lessened propensity to develop neutralizing antibodies. We aimed to compare the development of neutralizing antibodies against IFNβ between oligoclonal IgG band-negative and oligoclonal IgG band-positive multiple sclerosis patients. Treatment, oligoclonal IgG band and neutralizing antibody information was obtained for 2219 patients from the Swedish multiple sclerosis registry and the Swedish neutralizing antibody registry. Additional data on genotype was available for 532 patients. A correlation was found between oligoclonal IgG band negativity and neutralizing antibody negativity ( p = 0.02). This difference was confined to neutralizing antibodies against IFNβ-1a, since oligoclonal IgG band-negative patients were, to a lesser extent, neutralizing antibody positive compared with oligoclonal IgG band-positive patients if treated with IFNβ-1a (12% vs. 23%; p = 0.005). No difference was observed for IFNβ-1b-treated patients (44% vs. 46%). We propose that oligoclonal IgG band-negative patients differ immunologically from oligoclonal IgG band-positive patients, potentially influenced by distinct HLA-DRB1 alleles.

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