Breast-Conserving Therapy for Early-Stage Breast Cancer in Chinese Women: A Meta-Analysis of Case-Control Studies

Objective: To identify factors that influence Saskatchewan women’s choice between breast conserving therapy (BCT) and mastectomy in early-stage breast cancer (ESBC) and to compare and contrast underlying reasons behind choice of BCT versus mastectomy. Methods: Interpretive description methods guided this practice-based qualitative study. Data were analyzed using thematic analysis and presented in thematic maps. Results: Women who chose mastectomy described 1 of the 3 main themes: worry about cancer recurrence, perceived consequences of BCT treatment, or breast-tumor size perception. In contrast, women chose BCT because of 3 different themes: mastectomy being too radical, surgeon influence, and feminine identity. Conclusions: Although individual reasons for choosing mastectomy versus BCT have been discussed in the literature before, different rationale underlying each choice has not been previously described. These results are novel in identifying interdependent subthemes and secondary reasons for each choice. This is important for increased understanding of factors influencing a complicated decision-making process.

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10 Year Outcomes for Regional Nodal Failure in Early Stage Breast Cancer Patients Treated with Breast Conserving Therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2009.07.432 ◽

2009 ◽

Vol 75 (3) ◽

pp. S186 ◽

Cited By ~ 1

Author(s):

S.S. Park ◽

I.S. Grills ◽

L.L. Kestin ◽

C. Mitchell ◽

A.A. Martinez ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Early Stage ◽

Breast Conserving Therapy ◽

Early Stage Breast Cancer ◽

Breast Cancer Patients ◽

Nodal Failure

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Effect of multifocality and multicentricity on outcome in early stage breast cancer: a systematic review and meta-analysis

Breast Cancer Research and Treatment ◽

10.1007/s10549-014-3018-3 ◽

2014 ◽

Vol 146 (2) ◽

pp. 235-244 ◽

Cited By ~ 48

Author(s):

Francisco E. Vera-Badillo ◽

Marc Napoleone ◽

Alberto Ocana ◽

Arnoud J. Templeton ◽

Bostjan Seruga ◽

...

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Early Stage ◽

Meta Analysis ◽

Early Stage Breast Cancer

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Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

Cancers ◽

10.3390/cancers13225654 ◽

2021 ◽

Vol 13 (22) ◽

pp. 5654

Author(s):

Agnieszka Barańska ◽

Agata Błaszczuk ◽

Wiesław Kanadys ◽

Maria Malm ◽

Katarzyna Drop ◽

...

Keyword(s):

Breast Cancer ◽

Oral Contraceptive ◽

Cancer Risk ◽

Meta Analysis ◽

Case Control ◽

Cochrane Library ◽

Control Group ◽

Case Control Studies ◽

Increased Risk ◽

Breast Cancer Risk Assessment

To perform a meta-analysis of case-control studies that addressed the association between oral contraceptive pills (OC) use and breast cancer (BrCa), PubMED (MEDLINE), Embase, and the Cochrane Library were searched to identify case-control studies of OC and BrCa published between 2009 and 2020. We used the DerSimonian–Laird method to compute pooled odds ratios (ORs) and confidence intervals (CIs), and the Mantel–Haenszel test to assess the association between OC use and cancer. Forty-two studies were identified that met the inclusion criteria and we included a total of 110,580 women (30,778 into the BrCa group and 79,802 into the control group, of which 15,722 and 38,334 were using OC, respectively). The conducted meta-analysis showed that the use of OC was associated with a significantly increased risk of BrCa in general, OR = 1.15, 95% CI: 1.01 to 1.31, p = 0.0358. Regarding other risk factors for BrCa, we found that increased risk was associated significantly with early menarche, nulliparous, non-breastfeeding, older age at first parity, postmenopause, obesity, smoking, and family history of BrCa. Despite our conclusion that birth control pills increase the cancer risk being supported by extensive previous studies and meta-analyzes, further confirmation is required.

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