Ghrelin and Its Relation with N-Terminal Brain Natriuretic Peptide, Endothelin-1 and Nitric Oxide in Patients with Idiopathic Pulmonary Hypertension

Background: Hypertension is a major risk factor for cardiovascular disease (CVD), which is the number one cause of global mortality. The potential use of natural products to alleviate high blood pressure has been demonstrated to exert a cardioprotective effect. Centella asiatica (L.) Urb. belongs to the plant family Apiaceae (Umbelliferae). It contains a high amount of triterpenoid and flavonoid that have antioxidant properties and are involved in the renin-angiotensin-aldosterone system which is an important hormonal system for blood pressure regulation.Objective: This study aimed to investigate the effects of C. asiatica ethanolic extract on blood pressure and heart in a hypertensive rat model, which was induced using oral N(G)-nitro-l-arginine methyl ester (l-NAME).Methods: Male Sprague-Dawley rats were divided into five groups and were given different treatments for 8 weeks. Group 1 only received deionized water. Groups 2, 4, and 5 were given l-NAME (40 mg/kg, orally). Groups 4 and 5 concurrently received C. asiatica extract (500 mg/kg, orally) and captopril (5 mg/kg, orally), respectively. Group 3 only received C. asiatica extract (500 mg/kg body weight, orally). Systolic blood pressure (SBP) was measured at weeks 0, 4, and 8, while serum nitric oxide (NO) was measured at weeks 0 and 8. At necropsy, cardiac and aortic malondialdehyde (MDA) contents, cardiac angiotensin-converting enzyme (ACE) activity, and serum level of brain natriuretic peptide (BNP) were measured.Results: After 8 weeks, the administrations of C. asiatica extract and captopril showed significant (p < 0.05) effects on preventing the elevation of SBP, reducing the serum nitric oxide level, as well as increasing the cardiac and aortic MDA content, cardiac ACE activity, and serum brain natriuretic peptide level.Conclusion:C. asiatica extract can prevent the development of hypertension and cardiac damage induced by l-NAME, and these effects were comparable to captopril.

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Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats

Cardiovascular Research ◽

10.1016/0008-6363(95)00108-5 ◽

1995 ◽

Vol 30 (5) ◽

pp. 739-746 ◽

Cited By ~ 25

Author(s):

R Mathew

Keyword(s):

Nitric Oxide ◽

Pulmonary Hypertension ◽

Endothelin 1

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REMODELING OF THE RIGHT HEART AND THE LEVEL OF BRAIN NATRIURETIC PEPTIDE IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: A COMPARATIVE CROSS-SECTIONAL OBSERVATIONAL STUDY

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2013-9-3-258-264 ◽

2013 ◽

Vol 9 (3) ◽

pp. 258-264 ◽

Cited By ~ 1

Author(s):

A. A. Klimenko ◽

N. A. Shostak ◽

N. A. Demidova ◽

I. V. Novikov ◽

S. M. Sorokoletov ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Observational Study ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Chronic Thromboembolic Pulmonary Hypertension ◽

Right Heart ◽

Cross Sectional ◽

Thromboembolic Pulmonary Hypertension ◽

The Right

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INHALED NITRIC OXIDE: CLINICAL EFFECTS AND INFLUENCE ON THE PROFILE OF INFLAMMATORY MARKERS IN PATIENTS WITH IDIOPATHIC PULMONARY HYPERTENSION

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2012-8-4-500-508 ◽

2012 ◽

Vol 8 (4) ◽

pp. 500-508 ◽

Cited By ~ 1

Author(s):

T. V. Martynyuk ◽

S. N. Nakonechnikov ◽

V. P. Masenko ◽

I. E. Chazova

Keyword(s):

Nitric Oxide ◽

Pulmonary Hypertension ◽

Inflammatory Markers ◽

Inhaled Nitric Oxide ◽

Clinical Effects ◽

Idiopathic Pulmonary Hypertension

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Correlation Between N-Terminal Pro-Brain Natriuretic Peptide Levels and Cardiopulmonary Exercise Testing in Patients With Pre-Capillary Pulmonary Hypertension: A Pilot Study

Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine ◽

10.1177/1179548420954049 ◽

2020 ◽

Vol 14 ◽

pp. 117954842095404

Author(s):

Sahachat Aueyingsak ◽

Wilaiwan Khrisanapant ◽

Upa Kukongviriyapun ◽

Orapin Pasurivong ◽

Pailin Ratanawatkul ◽

...

Keyword(s):

Carbon Dioxide ◽

Pulmonary Hypertension ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Exercise Testing ◽

Cardiopulmonary Exercise Testing ◽

Chronic Thromboembolic Pulmonary Hypertension ◽

Peak Oxygen Uptake ◽

Cardiopulmonary Exercise ◽

End Tidal

Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiopulmonary exercise testing (CPET) are useful for severity assessment in patients with pulmonary hypertension (PH). Correlations between these tests in pre-capillary PH patients is less well studied. Methods: We studied 23 patients with pre-capillary PH: 8 with idiopathic pulmonary arterial hypertension (IPAH), 6 with systemic sclerosis-associated PAH (SSc-PAH), and 9 with chronic thromboembolic pulmonary hypertension (CTEPH). Clinical evaluation, NT-proBNP levels, six-minute walking test (6MWT), spirometry, and CPET were evaluated on the same day. Correlation between NT-proBNP levels and CPET parameters were investigated. Results: In all patients, NT-proBNP levels were significantly correlated with peak oxygen uptake (VO2) ( r = −0.47), peak oxygen pulse ( r = −0.43), peak cardiac output (CO) ( r = −0.57), peak end-tidal partial pressure of carbon dioxide (PETCO2) ( r = −0.74), ventilatory equivalent to carbon dioxide (VE/VCO2) at anaerobic threshold (AT) ( r = 0.73), and VE/VCO2 slope ( r = 0.64). Significant correlations between NT-proBNP levels and peak PETCO2 and VE/VCO2 were found in IPAH and CTEPH subgroups, and a significant correlation between NT-proBNP levels and VO2 at AT was found in the CTEPH subgroup. No significant correlation was found in the SSc-PAH subgroup. Conclusion: NT-proBNP levels were significantly correlated with CPET parameters in patients with IPAH and CTEPH subgroups, but not in SSc-PAH subgroup. A further study with larger population is required to confirm these preliminary findings.

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