Estimation of Background Incidence Rates of Guillain-Barré Syndrome in Germany - A Retrospective Cohort Study with Electronic Healthcare Data

2014 ◽  
Vol 43 (3-4) ◽  
pp. 244-252 ◽  
Author(s):  
Sabrina Hense ◽  
Tania Schink ◽  
Stefan H. Kreisel ◽  
Lydie Marcelon ◽  
François Simondon ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Incidence Rates ◽  
Guillain Barre Syndrome ◽  
Healthcare Data ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Sodium Levels Predict Disability at Discharge in Guillain-Barré Syndrome: A Retrospective Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Delia Gagliardi ◽  
Irene Faravelli ◽  
Manuel Alfredo Podestà ◽  
Roberta Brusa ◽  
Eleonora Mauri ◽  
...  
Keyword(s):  
Cohort Study ◽  
Serum Sodium ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Severe Disability ◽  
Guillain Barre Syndrome ◽  
Baseline Serum ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
The Impact

Guillain-Barré syndrome (GBS) is an inflammatory polyradiculopathy with potentially severe complications. Clinical tools for risk stratification have been developed, but no definitive prognostic biomarker has been reported. Hyponatremia is frequent in GBS patients, but the impact of serum sodium levels on clinical outcomes is still ill-defined. In this retrospective cohort study, we included all adult patients diagnosed with GBS spectrum disorders at our center from January 2010 to July 2020. Disability at discharge was assessed with the GBS Disability Score (GDS), and all clinical and laboratory data was retrieved from medical charts. Thirty (58.8%) of the 51 subjects included in the study were discharged with severe residual disability (GDS ≥ 3). After accounting for relevant confounders, the odds of experiencing severe disability decreased by 27% (p = 0.027) for each unitary increase in serum sodium concentration. Thirteen (25.5%) patients were diagnosed with mild to moderate hyponatremia; the use of intravenous immune globulin (IVIG) independently increased the odds of developing hyponatremia. In conclusion, we found a significant, independent association between baseline serum sodium levels and severe disability at discharge in GBS patients. In our cohort, hyponatremia was more frequently observed after treatment with IVIG, suggesting dilutional pseudohyponatremia as a probable cause.

scholarly journals Characterizing the incidence of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study

2021 ◽  
Author(s):  
Xintong Li ◽  
Anna Ostropolets ◽  
Rupa Makadia ◽  
Azza Shoaibi ◽  
Gowtham Rao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Adverse Events ◽  
Special Interest ◽  
Incidence Rates ◽  
Guillain Barre Syndrome ◽  
Administrative Claims ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Age And Sex

As large-scale immunization programs against COVID-19 proceed around the world, safety signals will emerge that need rapid evaluation.1,2 We report population-based, age- and sex-specific background incidence rates of potential adverse events of special interest (AESI) in eight countries using thirteen databases. This multi-national network cohort study included eight electronic medical record and five administrative claims databases from Australia, France, Germany, Japan, Netherlands, Spain, the United Kingdom and the United States, mapped to a common data model. People observed for at least 365 days before 1 January 2017, 2018, or 2019 were included. We based study outcomes on lists published by regulators: acute myocardial infarction, anaphylaxis, appendicitis, Bell s palsy, deep vein thrombosis, disseminated intravascular coagulation, encephalomyelitis, Guillain-Barre syndrome, hemorrhagic and non-hemorrhagic stroke, immune thrombocytopenia, myocarditis/pericarditis, narcolepsy, pulmonary embolism, and transverse myelitis.3 We calculated incidence rates stratified by age, sex, and database. We pooled rates across databases using random effects meta-analyses. We classified meta-analytic estimates into Council of International Organizations of Medical Sciences categories: very common, common, uncommon, rare, or very rare.4 We analyzed 126,661,070 people. Rates varied greatly between databases and by age and sex. Some AESI (e.g., myocardial infarction, Guillain-Barre syndrome) increased with age, while others (e.g., anaphylaxis, appendicitis) were more common in young people. As a result, AESI were classified differently according to age. For example, myocardial infarction was very rare in children, rare in women aged 35-54 years, uncommon in men and women aged 55-84 years, and common in those aged ≥85 years. We report robust baseline rates of prioritized AESI across 13 databases. Age, sex, and variation between databases should be considered if background AESI rates are compared to event rates observed with COVID-19 vaccines.

Papillomavirus vaccination and Guillain-Barre Syndrome among girls: A cohort study in Spain

Vaccine ◽  
2021 ◽  
Author(s):  
Elisa Martín-Merino ◽  
Belen Castillo-Cano ◽  
Mar Martín-Perez ◽  
Ana Llorente-García ◽  
Dolores Montero-Corominas
Keyword(s):  
Cohort Study ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Guillain-Barre Syndrome following Primary Cytomegalovirus Infection: A Prospective Cohort Study

2011 ◽  
Vol 52 (7) ◽  
pp. 837-844 ◽  
Author(s):  
D. Orlikowski ◽  
R. Porcher ◽  
V. Sivadon-Tardy ◽  
J.-C. Quincampoix ◽  
J.-C. Raphael ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Cytomegalovirus Infection ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Primary Cytomegalovirus Infection ◽  
Guillain Barré

scholarly journals Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study

2020 ◽  
Author(s):  
Hideki Fujii ◽  
Haruna Doi ◽  
Tetsuhisa Ko ◽  
Taito Fukuma ◽  
Toru Kadono ◽  
...  
Keyword(s):  
Cohort Study ◽  
Propensity Score ◽  
Fatty Liver ◽  
Propensity Score Matching ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Incidence Rates ◽  
Gamma Glutamyl Transferase ◽  
Liver Change ◽  
Glutamyl Transferase

Abstract Background Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound images and other abnormal liver enzymes levels. However, whether these individuals are at an elevated risk for developing fatty liver is unclear. We compared fatty liver change rates and risk factors between individuals with frequently elevated GGT levels and those with normal levels.Methods We designed a retrospective cohort study on the basis of complete medical checkup records. One group of individuals had presented normal serum GGT levels during the observation period (Normal-GGT group, n = 2713). Another group had had abnormal elevated serum GGT levels frequently (Abnormal-GGT group, n = 264). We determined the fatty liver change incident rates before and after propensity score matching. We explored confounding factors affecting fatty changes in each group using univariate and multivariate Cox models.Results The change incidence rates were 5.80/1000 and 10.02/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively. After propensity score matching, the incidence rates were 3.08/1000 and 10.18/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively (p = 0.026). The factors associated with fatty liver changes in the Normal-GGT group included body mass index (BMI), hemoglobin, alanine aminotransferase (ALT), albumin, triglyceride (TG), fasting blood sugar, and high-density lipoprotein levels. Those in the Abnormal-GGT group were platelet counts and TG. In our multivariable analysis, BMI, ALT, albumin, and TG levels were independent predictors of fatty changes in the Normal-GGT group, and high TG level was the only independent predictor in the Abnormal-GGT group.Conclusions The incidence rate of fatty liver change in the Abnormal-GGT group was higher than that in the Normal-GGT group. Consecutive elevated GGT levels increase the risk for fatty liver, and high TG levels in those individuals further independently increase the risk.Trial registration: NA

scholarly journals Relevance of anxiety in clinical practice of Guillain-Barré syndrome: a cohort study

BMJ Open ◽  
2012 ◽  
Vol 2 (4) ◽  
pp. e000893 ◽  
Author(s):  
Tarek Sharshar ◽  
Andrea Polito ◽  
Raphaël Porcher ◽  
Takoua Merhbene ◽  
Morgane Blanc ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Practice ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Complaint risk among mental health practitioners compared with physical health practitioners: a retrospective cohort study of complaints to health regulators in Australia

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e030525 ◽  
Author(s):  
Benjamin G Veness ◽  
Holly Tibble ◽  
Brin FS Grenyer ◽  
Jennifer M Morris ◽  
Matthew J Spittal ◽  
...  
Keyword(s):  
Mental Health ◽  
Cohort Study ◽  
Physical Health ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Incidence Rates ◽  
Mental Health Practitioners ◽  
National Study ◽  
Increased Risk ◽  
Health Practitioners

ObjectivesTo understand complaint risk among mental health practitioners compared with physical health practitioners.DesignRetrospective cohort study, using incidence rate ratios (IRRs) to analyse complaint risk and a multivariate regression model to identify predictors of complaints.SettingNational study using complaints data from health regulators in Australia.ParticipantsAll psychiatrists and psychologists (‘mental health practitioners’) and all physicians, optometrists, physiotherapists, osteopaths and chiropractors (‘physical health practitioners’) registered to practice in Australia between 2011 and 2016.Outcome measuresIncidence rates, source and nature of complaints to regulators.ResultsIn total, 7903 complaints were lodged with regulators over the 6-year period. Most complaints were lodged by patients and their families. Mental health practitioners had a complaint rate that was more than twice that of physical health practitioners (complaints per 1000 practice years: psychiatrists 119.1 vs physicians 48.0, p<0.001; psychologists 21.9 vs other allied health 7.5, p<0.001). Their risk of complaints was especially high in relation to reports, records, confidentiality, interpersonal behaviour, sexual boundary breaches and the mental health of the practitioner. Among mental health practitioners, male practitioners (psychiatrists IRR: 1.61, 95% CI 1.39 to 1.85; psychologists IRR: 1.85, 95% CI 1.65 to 2.07) and older practitioners (≥65 years compared with 36–45 years: psychiatrists IRR 2.37, 95% CI 1.95 to 2.89; psychologists IRR 1.78, 95% CI 1.47 to 2.14) were at increased risk of complaints.ConclusionsMental health practitioners were more likely to be the subject of complaints than physical health practitioners. Areas of increased risk are related to professional ethics, communication skills and the health of mental health practitioners themselves. Further research could usefully explore whether addressing these risk factors through training, professional development and practitioner health initiatives may reduce the risk of complaints about mental health practitioners.

Sign in / Sign up

Export Citation Format

Share Document