Indications for Plasma Exchange: Renal Diseases

2015 ◽  
pp. 145-152
Author(s):  
Ch. M. Lockwood ◽  
C. D. Pusey ◽  
D. K. Peters
Keyword(s):  
Plasma Exchange ◽  
Renal Diseases

scholarly journals Therapeutic plasma exchange for the treatment of pediatric renal diseases in 2013

2013 ◽  
Vol 29 (1) ◽  
pp. 35-50 ◽  
Author(s):  
Caitlin E. Carter ◽  
Nadine M. Benador
Keyword(s):  
Plasma Exchange ◽  
Therapeutic Plasma Exchange ◽  
Renal Diseases

scholarly journals Therapeutic Plasma Exchange in Renal Diseases: A Three-Year Retrospective Analysis

2019 ◽  
Vol 28 (2) ◽  
pp. 114-119
Author(s):  
Sibel Ersan ◽  
◽  
Fatma Liv ◽  
Sibel Demiral Sezer ◽  
Hulya Colak ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Retrospective Analysis ◽  
Therapeutic Plasma Exchange ◽  
Renal Diseases

scholarly journals Therapeutic plasma exchange in renal diseases.

1996 ◽  
Vol 7 (3) ◽  
pp. 367-386
Author(s):  
F Madore ◽  
J M Lazarus ◽  
H R Brady
Keyword(s):  
Plasma Exchange ◽  
Allograft Rejection ◽  
Therapeutic Plasma Exchange ◽  
Renal Diseases ◽  
Randomized Controlled ◽  
Cast Nephropathy ◽  
Myeloma Cast Nephropathy ◽  
Uremic Syndrome ◽  
Secondary Glomerulonephritis ◽  
Scientific Rationale

Plasma exchange has been used extensively for over 2 1/2 decades to treat a variety of renal diseases. In this article, the scientific rationale for therapeutic plasma exchange in primary and secondary glomerulonephritis, thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, myeloma cast nephropathy, and allograft rejection are reviewed. The clinical studies that evaluate its efficacy are summarized, with special emphasis on the results of randomized controlled trials, when available. Consensus plasma exchange regimens are presented for diseases in which there is evidence to support its use.

scholarly journals Therapeutic Plasma Exchange in Pediatrics for Immunologic Disorders; Tolerated and Safe Process for Pediatric Life-Threatening Conditions

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4986-4986
Author(s):  
Jean-Sebastien Diana ◽  
Sandra Manceau ◽  
Tioka Rabeony ◽  
Caroline Elie ◽  
anne-Marine Lenzotti ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Inflammatory Diseases ◽  
Therapeutic Plasma Exchange ◽  
Renal Diseases ◽  
Case Report Form ◽  
Solid Organ ◽  
Immune Disorder ◽  
Antibody Mediated Rejection ◽  
Increased Risk ◽  
Life Threatening

Therapeutic plasma exchange (TPE) is advocated as a treatment to several conditions and applications: solid organs transplantation, kidney and pediatric immune disorder. Apheresis for children diseases has been poorly investigated in mostly small, uncontrolled studies.The purpose was to report our experience, and provide uniform and relatable data, in order to improve disease management. We included 94 patients, aged under 18 years old, who underwent TPE in the pediatric center of Necker-Enfants-Malades hospital from January 2005 to December 2014. Data were retrospectively collected in an electronic case report form via a web-based data collection system. 78 patients were selected, including 36 females and 42 males with a median age of 9.78 years [range 0.53; 17.93]. They achieved a total number of 731 procedures. Indications were antibody-mediated rejection (n= 33; 42%) or desensitization therapy (n= 5; 6%) for solid organ or hematopoietic transplantations; microangiopathy (n= 17; 22%); renal diseases (n= 6; 8%) and pediatric inflammatory diseases (n= 16; 21%); or hyperviscosity syndrome (n = 1; 1%). Each patient had an average of 6 procedures for the first session [range 1; 19] with a median volume of 1834 ml [range 500; 5000 ml] corresponding to a median total plasma volume (TPV) equivalent of 1.39 l/m2[range: 0.58; 2.1 l/m2].Within 15 days in the beginning of the sessions, 72 patients (92%) presented a total of 311 Advers Events(AEs) potentially related to TPE. 94 AEs were not related to TPE sessions.There was a median of 5 AEs/patients [range: 0; 24]. There was no significant increased risk of AEs due to diseases, intensity of care, venous access, plasma substitute and body weight. Few of AEs were potentially life-threatening and concerned pediatric critical care situations. Allergic reactions represented only 20 AEs for 14 patients (grade I n= 18; grade II n= 1; grade III n= 1). At the endpoint of M12, 15 (19%) patients had died, no death had been related to the TPE process. Nine patients performed a second or a third session of procedures and 10 (13%) patients had severe persistent clinical disease. We describe one of the largest retrospective pediatric cohort to date, to the last international recommendations. Our experience on children TPE feasibility concern specific life‐threatening conditions and otherwise potential refractory diseases. TPE were generally well tolerated and the majority of the adverse effects were anticipated and could therefore be avoided. Based on this work, and in order to progress in the understanding of the TPE field, it would be interesting to increase pediatric data with prospective and multicenter cohort. Disclosures Cavazzana: Smartimmune: Other: Founder of Smartimmune.

PLASMA EXCHANGE IN THE TREATMENT OF GLOMERULONEPHRITIS AND OTHER RENAL DISEASES

1986 ◽  
Vol 16 (6) ◽  
pp. 828-838 ◽  
Author(s):  
R. G. WALKER ◽  
G. J. BECKER ◽  
A. J. F. d'APICE ◽  
P. KINCAID-SMITH
Keyword(s):  
Plasma Exchange ◽  
Renal Diseases

Treatment of renal diseases with plasma exchange: a single center experience

2005 ◽  
Vol 9 (5) ◽  
pp. A39-A39
Author(s):  
Kiril Nenov ◽  
Alexander Stoyanov ◽  
Dobrin Paskalev
Keyword(s):  
Plasma Exchange ◽  
Renal Diseases ◽  
Single Center ◽  
Single Center Experience

A rapid silver-impregnation technique on ultra-thin sections for Electron Microscopy

1993 ◽  
Vol 51 ◽  
pp. 242-243
Author(s):  
K. Chien ◽  
R.C. Heusser ◽  
M.L. Jones ◽  
R.L. Van de Velde
Keyword(s):  
Electron Microscopy ◽  
Silver Nitrate ◽  
Silver Impregnation ◽  
Sodium Borate ◽  
Renal Diseases ◽  
Distilled Water ◽  
Thin Sections ◽  
Impregnation Technique ◽  
Centrifuge Tube ◽  
Simplified Procedure

Silver impregnation techniques have been used for the demonstration of the complex carbohydrates in electron microscopy. However, the silver stains were believed to be technically sensitive and time consumming to perform. Currently, due to the need to more specifically evaluate immune complex for localization in certain renal diseases, a simplified procedure in conjunction with the use of the microwave has been developed and applied to renal and other biopsies. The procedure is as follows:Preparation of silver methenamine solution:1. 15ml graduated, clear polystyrene centrifuge tube (Falcon, No. 2099) was rinsed once with distilled water.2. 3% hexamethylene tetramine (methenamine) was added into the centrifuge tube to the 6ml mark.3. 3% silver nitrate was added slowly to the methenamine to the 7ml mark while agitating. (Solution will instantly turn milky in color and then clear rapidly by mixing. No precipitate should be formed).4. 2% sodium borate was added to the solution to the 8ml mark, mixed and centrifuged before use.

Goodpasture syndrome treated with immunosuppression and plasma exchange

1977 ◽  
Vol 137 (8) ◽  
pp. 1076-1078 ◽  
Author(s):  
C. H. Lang
Keyword(s):  
Plasma Exchange ◽  
Goodpasture Syndrome

Plasma Exchange in SLE

The Lancet ◽  
1980 ◽  
Vol 315 (8167) ◽  
pp. 688-689
Keyword(s):  
Plasma Exchange
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