Isolated Optic Disc Tuberculosis

We present a healthy male subject who developed progressive visual loss in the left eye initially diagnosed as optic neuritis. Upon suspicion of infectious etiology, testing was positive for tuberculosis. There were no signs or symptoms of active systemic tuberculosis infection. The patient responded swiftly to antimycobacterial therapy with return of vision and resolution of disc swelling. Positive purified protein derivative skin test, negative chest radiograph, negative systemic workup, negative workup for other causes of unilateral optic neuritis and quick response to mycobacterial therapy reaffirm the entity of isolated optic disc tuberculosis similar to isolated choroidal tuberculosis without systemic manifestation.

Download Full-text

A Multiple Dose of HL237 in Healthy Male Subject

Case Medical Research ◽

10.31525/ct1-nct03896594 ◽

2019 ◽

Author(s):

Keyword(s):

Multiple Dose ◽

Male Subject ◽

Healthy Male Subject ◽

Healthy Male

Download Full-text

Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis

BMC Ophthalmology ◽

10.1186/s12886-018-0949-1 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 1

Author(s):

Mário Luiz R. Monteiro ◽

Kenzo Hokazono ◽

Leonardo P. Cunha ◽

Laurentino Biccas Neto

Keyword(s):

Optic Neuritis ◽

Optic Disc ◽

Optic Atrophy ◽

Visual Loss ◽

Optic Disc Edema ◽

Disc Edema ◽

Acute Visual Loss ◽

Optic Disc Drusen

Download Full-text

Visual loss with chronic meningeal and systemic inflammation

Practical Neurology ◽

10.1136/practneurol-2021-003066 ◽

2021 ◽

pp. practneurol-2021-003066

Author(s):

Peter M Fernandes ◽

Lucy Kinton ◽

Stephen Madill ◽

Frederick R Burgess ◽

Euan McRorie ◽

...

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Annual Meeting ◽

Optic Disc ◽

Patient Outcomes ◽

Inflammatory Markers ◽

Visual Loss ◽

Targeted Treatments ◽

Infection And Inflammation ◽

Bilateral Sensorineural Hearing Loss

A 46-year-old man presented with worsening vision in the context of long-standing optic disc changes, bilateral sensorineural hearing loss, chronic aseptic meningitis, rash, arthralgia and raised inflammatory markers. The differential diagnoses of neoplasia, infection and inflammation are discussed. We highlight a condition that can present to adult neurologists, with successful diagnosis leading to targeted treatments that transform patient outcomes. This case was presented at the Association of British Neurologists Annual Meeting 2020 as a Clinicopathological Conference (CPC).

Download Full-text

Acute visual loss in a patient with optic disc drusen

Clinical Ophthalmology ◽

10.2147/opth.s42233 ◽

2013 ◽

pp. 795 ◽

Cited By ~ 2

Author(s):

Deborah Tan ◽

Sharon Tow

Keyword(s):

Optic Disc ◽

Visual Loss ◽

Acute Visual Loss ◽

Optic Disc Drusen

Download Full-text

Different Characteristics of Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibody-Seropositive Male Optic Neuritis in China

Journal of Ophthalmology ◽

10.1155/2019/4015075 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Honglu Song ◽

Huanfen Zhou ◽

Mo Yang ◽

Junqing Wang ◽

Hongjuan Liu ◽

...

Keyword(s):

Visual Acuity ◽

Optic Neuritis ◽

Ganglion Cell ◽

Nerve Fiber ◽

Optic Disc ◽

Myelin Oligodendrocyte Glycoprotein ◽

Aquaporin 4 ◽

Optic Disc Swelling ◽

Male Patients ◽

Retinal Nerve Fiber

Purpose. To describe different clinical characteristics and prognosis of optic neuritis (ON) in male patients with seropositive aquaporin-4 antibody (AQP4-Ab) or myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China. Method. Males with ON were recruited from the Neuro-ophthalmology Department of the Chinese People’s Liberation Army, General Hospital from January 2016 to February 2018. They were assigned to two groups based on antibodies status: MOG-Ab-seropositive ON (MOG-ON) and aquaporin-4 Ab-seropositive ON (AQP4-ON). Results. Seventy-six male patients were assessed, including 44 MOG-ON (57.9%) and 32 AQP4-ON (42.1%). The MOG-ON patients were significantly younger at onset compared to the AQP4-ON group (p<0.001). Frequencies of optic disc swelling, presence of abnormal autoimmune antibodies, and elevated levels of CSF IgG were significantly higher in the AQP4-ON group than the MOG-ON group (p=0.040, p=0.016, and p=0.10, respectively). At the final visit, 85.3% of MOG-ON eyes had increased visual acuity (≥0.5) compared to 35.1% of AQP4-ON eyes (p<0.001). The ratio of this steroid-dependent condition is higher in MOG-ON patients than the AQP4-ON group (p<0.001). The ratio of conversion to NMO is higher in the AQP4-ON group than the MOG-ON group, with more AQP4-ON patients developing NMO by the follow-up (p=0.012). MOG-ON patients had thicker average peripapillary retinal nerve fiber layers and macular ganglion cell-inner plexiform than AQP4-ON patients (p=0.008 and p=0.012, respectively). Orbital MRI revealed more AQP4-ON patients had chiasmal involvement than MOG-ON patients (p<0.001). Conclusion. Male MOG-ON patients had different clinical features including earlier age of onset, higher optic disc swelling ratio, better visual acuity recovery, thicker peripapillary retinal nerve fiber and macular ganglion cell-inner plexiform layers, and less chiasmal involvement than male AQP4-ON patients. Serum antibody may be a potential biomarker for determining visual prognosis in male ON.

Download Full-text

The Effect of Neonatal Bacille Calmette-Guérin Vaccination on Purified Protein Derivative Skin Test Results in Canadian Aboriginal Children

CHEST Journal ◽

10.1378/chest.06-1133 ◽

2007 ◽

Vol 131 (6) ◽

pp. 1806-1810 ◽

Cited By ~ 19

Author(s):

John K. Reid ◽

Heather Ward ◽

Darcy Marciniuk ◽

Shauna Hudson ◽

Pamela Smith ◽

...

Keyword(s):

Skin Test ◽

Test Results ◽

Bacille Calmette Guerin ◽

Purified Protein Derivative ◽

Aboriginal Children

Download Full-text

The clinical role of purified protein derivative skin test reaction in patients with non-muscle invasive bladder cancer treated with bacillus-Calmette Guerin.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.4545 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 4545-4545

Author(s):

Eiji Kikuchi ◽

Naoya Niwa ◽

Nozomi Hayakawa ◽

Ryuichi Mizuno ◽

Mototsugu Oya

Keyword(s):

Side Effects ◽

Skin Test ◽

Tumor Recurrence ◽

Skin Tests ◽

Test Reaction ◽

Muscle Invasive Bladder Cancer ◽

Purified Protein Derivative ◽

Bcg Therapy ◽

Muscle Invasive ◽

Skin Test Reaction

4545 Background: We investigated the association between purified protein derivative (PPD) skin test reaction prior to BCG therapy and clinical outcomes, both oncological outcomes and occurrence of side effects, in BCG-naïve non-muscle invasive bladder cancer (NMIBC) patients. Methods: A total of 288 NMIBC patients who received PPD skin test prior to BCG therapy were included. The PPD skin test reaction was categorized into three groups: positive, slightly positive, and negative. The presence of an induration was positive. If an induration was absent, an erythema 10 mm or more and less than 10 mm corresponds to slightly positive and negative, respectively. Results: Sixty-six (22.9%), 149 (51.7%), and 73 (25.3%) patients had positive, slightly positive, and negative PPD skin test results, respectively. The 5-year recurrence-free survival rate of patients with a positive PPD skin test was 89.4±4.1%, which was significantly higher than that of patients with slightly positive (65.5±4.2%, p = 0.001) and negative (56.4±6.6%, p < 0.001) results. Multivariate Cox regression analysis demonstrated that a positive PPD skin test was independently associated with tumor recurrence (Hazard ratio of 0.213, p < 0.001) but not with stage progression. The occurrence rate of major side effects in patients with a positive BCG skin test (33.3%) was significantly higher than that in patients with slightly positive (26.8%) and negative PPD skin tests (13.7%). The incidence rate of fever persisting beyond 2 days or fever of ≥38°C in patients with a positive PPD skin test (18.2%) was significantly higher than that in patients with slightly positive (8.7%) and negative PPD skin tests (4.1%). Conclusions: NMIBC patients with a positive PPD skin test and who were treated with BCG therapy had a significantly lower tumor recurrence rate and higher incidence of major side effects such as fever persisting beyond 2 days or fever of ≥38°C. Our findings suggest that PPD skin test prior to BCG therapy can predict clinical outcomes following BCG therapy and provide useful information regarding who would experience a strong therapeutic effect for BCG therapy and BCG-related major side effects.

Download Full-text