scholarly journals Energy Metabolism and Ageing in the Mouse: A Mini-Review

Gerontology ◽  
2017 ◽  
Vol 63 (4) ◽  
pp. 327-336 ◽  
Author(s):  
Vian Azzu ◽  
Teresa G. Valencak
Keyword(s):  
Energy Metabolism ◽  
Metabolic Rate ◽  
Mouse Models ◽  
Model Organism ◽  
Transgenic Mouse Models ◽  
Progressive Decline ◽  
Short Lifespan ◽  
Mutant Strains ◽  
Extended Lifespan ◽  
Over Time

The mouse has rapidly become the mammalian model organism of choice in ageing research due to its relatively short lifespan, the proximity of its genome and physiology to humans, and most importantly due to its genetic pliability and the availability of mutant strains. Mouse models have provided great insights into the ageing process, which in its broadest sense is the progressive decline of body functions over time. In this mini-review, we briefly cover the historical views on the link between ageing and metabolic rate, highlight genetically modified transgenic mouse models of extended lifespan, discuss endocrine pathways linked to senescence and ageing, and then examine pathways by which caloric restriction is postulated to result in longevity.

scholarly journals Forward genetic screen forCaenorhabditis elegansmutants with a shortened locomotor healthspan

2018 ◽  
Author(s):  
Kazuto Kawamura ◽  
Ichiro N. Maruyama
Keyword(s):  
Progressive Decline ◽  
Forward Genetic Screen ◽  
C Elegans ◽  
Short Lifespan ◽  
Elongator Complex ◽  
Age Related ◽  
Mutant Strains ◽  
Complex Protein ◽  
Locomotor Impairment ◽  
Locomotor Deficits

AbstractTwo people with the same lifespan do not necessarily have the same healthspan. One person may retain locomotor and cognitive functions until the end of life, while another person may lose them during adulthood. Unbiased searches for genes that are required to maintain locomotor capacities during adulthood may uncover key regulators of locomotor healthspan. Here, we take advantage of the relatively short lifespan of the nematodeCaenorhabditis elegansand develop a novel screening procedure to collect mutants with locomotor deficits that become apparent in adulthood. After ethyl methanesulfonate mutagenesis, we isolated fiveC. elegansmutant strains that progressively lose adult locomotor activity. In one of the mutant strains, a nonsense mutation in Elongator Complex Protein Component 2 (elpc-2)causes a progressive decline in locomotor function. Mutants and mutations identified in the present screen may provide insights into mechanisms of age-related locomotor impairment and the maintenance of locomotor healthspan.

Transgenic mouse models of type I diabetes

Diabetes ◽  
1990 ◽  
Vol 39 (8) ◽  
pp. 879-884 ◽  
Author(s):  
M. A. Lipes ◽  
G. S. Eisenbarth
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Type I Diabetes ◽  
Type I ◽  
Transgenic Mouse Models

scholarly journals Characterization of tumor‐associated macrophages in prostate cancer transgenic mouse models

The Prostate ◽  
2021 ◽  
Author(s):  
Amber E. Groot ◽  
Kayla V. Myers ◽  
Timothy E. G. Krueger ◽  
Ashley L. Kiemen ◽  
Natalia H. Nagy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Transgenic Mouse Models ◽  
Tumor Associated Macrophages

2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer

2012 ◽  
Vol 77 ◽  
pp. 40-58 ◽  
Author(s):  
Megan A.S. Penno ◽  
Manuela Klingler-Hoffmann ◽  
Julie A. Brazzatti ◽  
Alex Boussioutas ◽  
Tracy Putoczki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Human Gastric Cancer ◽  
Transgenic Mouse Models ◽  
Protein Biomarkers ◽  
2D Dige ◽  
Candidate Protein ◽  
Dige Analysis
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