The Pathophysiological Mechanism and Treatment of Secondary Brain Insult of Hypertensive Intracerebral Hemorrhage

Hypertensive intracerebral hemorrhage (HICH) is a type of acute cerebrovascular disease with high rates of incidence, mortality, and disability, and is a cause of more frequent instances of secondary brain insult (SBI). In-depth study of the pathogenesis and pathophysiological mechanisms of SBI in HICH contributes to its clinical treatment and prognosis. This article presents a brief summary of the pathophysiological mechanism and treatment of SBI after HICH.

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An Epidemiological Analysis of Risk Factors of Cerebrovascular Disease(The First Report) : Hypertensive Intracerebral Hemorrhage

Japanese Journal of Neurosurgery ◽

10.7887/jcns.7.284 ◽

1998 ◽

Vol 7 (5) ◽

pp. 284-290

Author(s):

Motoo KUBOTA ◽

Akira YAMAURA ◽

Jun-ichi ONO ◽

Toru ITANI ◽

Norihide TACHI ◽

...

Keyword(s):

Risk Factors ◽

Intracerebral Hemorrhage ◽

Cerebrovascular Disease ◽

Epidemiological Analysis ◽

First Report ◽

Hypertensive Intracerebral Hemorrhage

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White Matter Injury and Recovery after Hypertensive Intracerebral Hemorrhage

BioMed Research International ◽

10.1155/2017/6138424 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 17

Author(s):

Shilun Zuo ◽

Pengyu Pan ◽

Qiang Li ◽

Yujie Chen ◽

Hua Feng

Keyword(s):

White Matter ◽

Intracerebral Hemorrhage ◽

White Matter Injury ◽

Pathophysiological Mechanism ◽

Research Perspective ◽

Stroke Research ◽

The Face ◽

Injury And Repair ◽

Hypertensive Intracerebral Hemorrhage ◽

White Matter Repair

Hypertensive intracerebral hemorrhage (ICH) could very probably trigger white matter injury in patients. Through the continuous study of white matter injury after hypertensive ICH, we achieve a more profound understanding of the pathophysiological mechanism of its occurrence and development. At the same time, we found a series of drugs and treatment methods for the white matter repair. In the current reality, the research paradigm of white matter injury after hypertensive ICH is relatively obsolete or incomplete, and there are still lots of deficiencies in the research. In the face of the profound changes of stroke research perspective, we believe that the combination of the lenticulostriate artery, nerve nuclei of the hypothalamus-thalamus-basal ganglia, and the white matter fibers located within the capsula interna will be beneficial to the research of white matter injury and repair. This paper has classified and analyzed the study of white matter injury and repair after hypertensive ICH and also rethought the shortcomings of the current research. We hope that it could help researchers further explore and study white matter injury and repair after hypertensive ICH.

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Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Frontiers in Pharmacology ◽

10.3389/fphar.2019.01079 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 10

Author(s):

Zhiwei Shao ◽

Sheng Tu ◽

Anwen Shao

Keyword(s):

Intracerebral Hemorrhage ◽

Therapeutic Targets ◽

Pathophysiological Mechanisms

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Factor V Leiden Mutation in Cerebrovascular Disease

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/107602960501100314 ◽

2005 ◽

Vol 11 (3) ◽

pp. 339-342 ◽

Cited By ~ 4

Author(s):

Nur Buyru ◽

Julide Altinisik ◽

Goksel Somay ◽

Turgut Ulutin

Keyword(s):

Ischemic Stroke ◽

Intracerebral Hemorrhage ◽

Cerebrovascular Disease ◽

Smoking Status ◽

Factor V Leiden ◽

Restriction Enzyme Digestion ◽

Factor V ◽

Mutation Site ◽

Factor V Leiden Mutation ◽

High Prevalence

Several studies indicate a high prevalence of factor V Leiden mutation as the most frequent coagulation defect found in patients with venous thrombosis. The relationship between this mutation and cerebrovascular disease has not been established in adults. In this investigation, we studied 29 patients with ischemic stroke and 20 with intracerebral hemorrhage, all of whom were compared with 20 controls. A region of the factor V gene containing the Leiden mutation site was amplified with polymerase chain reaction and the presence of mutation was determined with restriction enzyme digestion. We found no evidence of an association between factor V Leiden mutation and ischemic stroke or intracerebral hemorrhage. There was no evidence of association in subgroup the analysis by age, smoking status, myocardial infarction, hypertension, diabetes mellitus, or coronary disease. Factor V Leiden mutation doesn’t seem to be associated with a risk of cerebrovascular disease.

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