Simultaneous Stimulation of the Globus Pallidus Interna and the Nucleus Basalis of Meynert in the Parkinson-Dementia Syndrome

2019 ◽  
Vol 47 (1-2) ◽  
pp. 19-28 ◽  
Author(s):  
Cristina Nombela ◽  
Andrés Lozano ◽  
Clara Villanueva ◽  
Juan A. Barcia
Keyword(s):  
Globus Pallidus ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Cognitive Symptoms ◽  
Dementia Syndrome ◽  
Electrode Lead ◽  
Parkinson Dementia ◽  
Deep Brain ◽  
Stimulation Of

Background/Aim: The prevalence of cognitive symptoms in recently diagnosed Parkinson’s disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. Methods: A PD patient diagnosed with mild cognitive impairment underwent DBS surgery targeting the globus pallidus interna (GPi; to treat motor symptoms) and the nucleus basalis of Meynert (NBM; to treat cognitive symptoms) using a single electrode per hemisphere. Results: Compared to baseline, 2-month follow-up after GPi stimulation was associated with motor improvements, whereas partial improvements in cognitive functions were observed 3 months after the addition of NBM stimulation to GPi stimulation. Conclusion: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead.

Changes in apraxia after deep brain stimulation of the nucleus basalis Meynert in a patient with Parkinson dementia syndrome

2010 ◽  
Vol 25 (10) ◽  
pp. 1519-1520 ◽  
Author(s):  
Thomas T. Barnikol ◽  
Norbert B. A. Pawelczyk ◽  
Utako B. Barnikol ◽  
Jens Kuhn ◽  
Doris Lenartz ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Nucleus Basalis ◽  
Dementia Syndrome ◽  
Parkinson Dementia ◽  
Deep Brain ◽  
Stimulation Of

Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus

2008 ◽  
Vol 109 (1) ◽  
pp. 130-132 ◽  
Author(s):  
Brigitte Biolsi ◽  
Laura Cif ◽  
Hassan El Fertit ◽  
Santiago Gil Robles ◽  
Philippe Coubes
Keyword(s):  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Huntington Disease ◽  
Internal Globus Pallidus ◽  
Efficient Treatment ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation is now accepted as a safe and efficient treatment for movement disorders including selected types of dystonia and dyskinesia. Very little, however, is known about its effect on other movement disorders, particularly for “choreic” movements. Huntington disease is a fatal autosomal-dominant neurodegenerative disorder characterized by movement disorders, progressive cognitive impairment, and psychiatric symptoms. Bilateral chronic stimulation of the internal globus pallidus was performed to control choreic movements in a 60-year-old man with a 10-year history of Huntington disease. Chronic deep brain stimulation resulted in remarkable improvement of choreic movements. Postoperative improvement was sustained after 4 years of follow-up with a marked improvement in daily quality of life.

scholarly journals Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

2014 ◽  
Vol 20 (3) ◽  
pp. 353-360 ◽  
Author(s):  
J Kuhn ◽  
K Hardenacke ◽  
D Lenartz ◽  
T Gruendler ◽  
M Ullsperger ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Alzheimer’S Dementia ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Alzheimer's Dementia ◽  
Deep Brain ◽  
Stimulation Of

Long term follow-up results of deep brain stimulation of the Globus pallidus interna in pediatric patients with DYT1-positive dystonia

2021 ◽  
Vol 201 ◽  
pp. 106449
Author(s):  
Mona Ramezani Ghamsari ◽  
Shadi Ghourchian ◽  
Maziar Emamikhah ◽  
Mahdi Safdarian ◽  
Gholamali Shahidi ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Pediatric Patients ◽  
Long Term Follow Up ◽  
Deep Brain ◽  
Stimulation Of

Restoration of erect posture in idiopathic camptocormia by electrical stimulation of the globus pallidus internus

2010 ◽  
Vol 113 (6) ◽  
pp. 1246-1250 ◽  
Author(s):  
Damianos E. Sakas ◽  
Ioannis G. Panourias ◽  
Lampis C. Stavrinou ◽  
Efstathios J. Boviatsis ◽  
Marios Themistocleous ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Young Patients ◽  
Globus Pallidus Internus ◽  
Bipedal Walking ◽  
Oscillatory Activity ◽  
Drug Resistant ◽  
Erect Posture ◽  
Deep Brain ◽  
Stimulation Of

The authors report on 2 young patients who developed drug-resistant idiopathic dystonic camptocormia (bent spine) and were treated successfully by deep brain stimulation (DBS) of the globus pallidus internus (GPi). The first patient, a 26-year-old woman, suffered for 3 years from such severe camptocormia that she became unable to walk and was confined to bed or a wheelchair. The second patient, a 21-year-old man, suffered for 6 months from less severe camptocormia; he was able to walk but only for short distances with a very bent spine, the arms in a parallel position to the legs, and the hands almost approaching the floor to potentially support him in case of a forward fall. Within a few days following DBS, both patients experienced marked clinical improvement. At most recent follow-up (44 months in one case and 42 in the other), the patients' ability to walk upright remained normal. Similar findings have only been reported recently in a few cases of camptocormia secondary to Parkinson disease or tardive dyskinesia. On the basis of the experience of these 2 idiopathic cases and the previously reported cases of secondary camptocormia with a favorable response to GPi DBS, the authors postulate that specific patterns of oscillatory activity in the GPi are vital for the maintenance of erect posture and the adoption of bipedal walking by humans.

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