Prevalence and Predictors of Growth Impairment and Short Stature in Pediatric-Onset Inflammatory Bowel Disease

Digestion ◽  
2019 ◽  
Vol 101 (6) ◽  
pp. 674-682
Author(s):  
Firas Rinawi ◽  
Amit Assa ◽  
Tal Almagor ◽  
Tomer Ziv-Baran ◽  
Raanan Shamir
Keyword(s):  
Risk Factors ◽  
Short Stature ◽  
Adult Height ◽  
Male Gender ◽  
Z Score ◽  
Growth Impairment ◽  
Bowel Diseases ◽  
Z Scores ◽  
Inflammatory Bowel ◽  
Pediatric Onset

<b><i>Background and Aims:</i></b> Growth impairment is common in children with inflammatory bowel diseases (IBD). However, the magnitude of short stature at adulthood is not well characterized. We aimed to determine the prevalence and predictors of growth impairment at diagnosis and adulthood in children with IBD. <b><i>Methods:</i></b> Height z-scores at diagnosis of IBD and at adulthood among 291 children with Crohn’s disease (CD) and 125 with ulcerative colitis (UC) were retrieved retrospectively and compared to matched controls. Growth impairment at diagnosis was defined as height z-score for age less than or equal to –1 and short stature at adulthood as less than or equal to –2. <b><i>Results:</i></b> Mean height z-score at adulthood in subjects with CD or UC was significantly different from controls although mean height did differ in males only (CD 172.3 cm ± 6.7, UC 172.7 cm ± 5.3, controls: 174.2 cm ± 7.3, <i>p</i> = 0.003 and <i>p</i> = 0.047, respectively). Diagnosis prior to final stage of puberty and male gender were risk factors for being short statured at adulthood in CD (mean difference [MD] 2.5, <i>p</i> = 0.013 and MD 6.25, <i>p</i> = 0.001, respectively) and UC (MD 4.9, <i>p</i> = 0.011 and MD 3.3, <i>p</i> = 0.034, respectively). <b><i>Conclusion:</i></b> Increased proportion of pediatric-onset IBD patients has growth impairment at adulthood. Male gender and diagnosis prior to puberty were found to impose risk for reduced adult height in both diseases.

Sa574 RISK FACTORS FOR DISORDERED EATING AMONG PATIENTS WITH INFLAMMATORY BOWEL DISEASES

2021 ◽  
Vol 160 (6) ◽  
pp. S-557-S-558
Author(s):  
Gianna Stoleru ◽  
Andrew R. Leopold ◽  
Amanda Auerbach ◽  
Shelley Nehman ◽  
Uni Wong
Keyword(s):  
Risk Factors ◽  
Disordered Eating ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals 1119 Genetic Risk Factors for Serious Infections in Inflammatory Bowel Diseases

2016 ◽  
Vol 150 (4) ◽  
pp. S224-S225
Author(s):  
Saranya Sasidharan ◽  
Vijay Yajnik ◽  
Hamed Khalili ◽  
John Garber ◽  
Comas Giallourakis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Diseases ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Serious Infections ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Mo1776 Final Adult Height of Patients With Pediatric Onset Inflammatory Bowel Disease in Japan

2016 ◽  
Vol 150 (4) ◽  
pp. S773
Author(s):  
Takashi Ishige ◽  
Takeshi Tomomasa ◽  
Reiko Hatori ◽  
Maiko Tatsuki ◽  
Hirokazu Arakawa
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Adult Height ◽  
Final Adult Height ◽  
Inflammatory Bowel ◽  
Pediatric Onset

scholarly journals Articular manifestations in patients with inflammatory bowel disease treated with vedolizumab

Rheumatology ◽  
2020 ◽  
Vol 59 (11) ◽  
pp. 3275-3283 ◽  
Author(s):  
Anastasia Dupré ◽  
Michael Collins ◽  
Gaétane Nocturne ◽  
Franck Carbonnel ◽  
Xavier Mariette ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Bowel Diseases ◽  
History Of ◽  
Musculoskeletal Manifestations ◽  
Inflammatory Bowel

Abstract Objective Vedolizumab (VDZ) has been incriminated in the occurrence of articular manifestations in patients with inflammatory bowel diseases (IBDs). The aim of this study was to describe musculoskeletal manifestations occurring in IBD patients treated by VDZ and to identify risk factors. Methods In this retrospective monocentric study, we included all consecutive patients treated by VDZ for IBD in our hospital. Incident musculoskeletal manifestations occurring during VDZ treatment were analysed and characteristics of patients with and without articular inflammatory manifestations were compared. Results Between 2013 and 2017, 112 patients were treated with VDZ for IBD: ulcerative colitis (n = 59), Crohn’s disease (n = 49) and undetermined colitis (n = 4). Four patients (3.6%) had a history of SpA, whereas 13 (11.6%) had a history of peripheral arthralgia. Some 102 (91.1%) patients had previously received anti-TNF. After a mean (S.d.) follow-up of 11.4 (8.6) months, 32 (28.6%) patients presented 35 musculoskeletal manifestations, of which 18 were mechanical and 17 inflammatory. Among the latter, 11 had axial or peripheral SpA, 5 had early reversible arthralgia and 1 had chondrocalcinosis (n = 1). Among the 11 SpA patients, only 3 (2.6%) had inactive IBD and may be considered as paradoxical SpA. The only factor associated with occurrence of inflammatory manifestations was history of inflammatory articular manifestation [7/16 (43.8%) vs 10/80 (12.5%), P = 0.007]. Conclusion Musculoskeletal manifestations occurred in almost 30% of IBD patients treated with VDZ, but only half of them were inflammatory. Since most of the patients previously received anti-TNF, occurrence of inflammatory articular manifestations might rather be linked to anti-TNF discontinuation than to VDZ itself.

scholarly journals Raman Spectroscopy as Noninvasive Method of Diagnosis of Pediatric Onset Inflammatory Bowel Disease

2020 ◽  
Vol 10 (19) ◽  
pp. 6974
Author(s):  
Giuseppe Acri ◽  
Valentina Venuti ◽  
Stefano Costa ◽  
Barbara Testagrossa ◽  
Salvatore Pellegrino ◽  
...  
Keyword(s):  
Operating Characteristic ◽  
Spectroscopic Method ◽  
Duodenal Biopsy ◽  
Noninvasive Method ◽  
Spectral Signatures ◽  
Spectral Changes ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Cellular Modifications ◽  
Pediatric Onset

We propose here a spectroscopic method to diagnose and differentiate inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD) with pediatric onset, in a complete noninvasive way without performing any duodenal biopsy. In particular, the Raman technique was applied to proteic extract from fecal samples in order to achieve information about molecular vibrations that can potentially furnish spectral signatures of cellular modifications occurring as a consequence of specific pathologic conditions. The attention was focused on the investigation of the amide I region, quantitatively accounting the spectral changes in the secondary structures by applying deconvolution and curve-fitting. Inflammation is found to give rise to a significant increasing of the nonreducible (trivalent)/reducible (divalent) cross-linking ratio R of the protein network. This parameter revealed an excellent marker in order to distinguish IBD subjects from non-IBD ones, and, among IBD patients, to differentiate between UC and CD. The proposed methodology was validated by statistical analysis using the receiver operating characteristic (ROC) curve.

scholarly journals SAT-LB14 Anthropometry and Vertebral Abnormality in Children With Transfusion-Dependent Thalassemia in Phramongkutklao Hospital, Bangkok, Thailand

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Nawachai Lertvivatpong ◽  
Voraluck Phatarakijnirund
Keyword(s):  
Short Stature ◽  
Adult Height ◽  
Screening Program ◽  
Multivariate Logistic Regression Analysis ◽  
Growth Failure ◽  
Bone Age ◽  
Team Approach ◽  
Z Score ◽  
Lower Segment ◽  
Tertiary Center

Abstract Anthropometry and vertebral abnormality in Children with Transfusion-dependent Thalassemia in Phramongkutklao HospitalBackgrounds: Thalassemia is an untreatable inherited hematologic disorder, unless stem cell transplantation, characterized by anemia from decreased hemoglobin production. Growth failure is one of the most common endocrine dysfunction in children with transfusion-dependent thalassemia (TDT) Objective: To evaluate the prevalence and associated factors of anthropometry and vertebral abnormality in transfusion-dependent thalassemia (TDT) children in a single tertiary center. Method: A cross-sectional study was conducted in transfusion dependent thalassemia patients who had visited in pediatric hematology clinic during 1st January 2018 to 31st December 2019. Collaborators had examined by history taking, physical examinations, laboratory and radiology reviewed. Results: Eighty-one collaborators were enrolled. Mean age was 13.7 ± 6.4 years and 46 of them (56.8%) were male. Pre-transfusion Hb and serum ferritin were 8.0 ± 1.0 g/dL and 1,562 + 1,394 ng/mL, respectively. Twenty-one (25.9%) had short stature determined by predicted adult height (PAH) below target adult height (TAH), 27(33.3%) had decreased upper-lower segment ratio for and 21 (26%) had BMI z-score below -2SD for age. Delay puberty was found in 13.2% of patients. Radiological examinations revealed delayed bone age of 4.9% and osteopenia of 25.9% whereas no vertebral fracture was documented. In multivariate logistic regression analysis (backward Wald), Serum ALP (p=0.009), mean pre-transfusion hemoglobin &lt;9 g/dL (p&lt;0.001), osteopenia (p=0.05) and delay bone age (p=0.019) were associated with PAH below TAH. Duration of chelation (p=0.013) and osteopenia (p=0.015) were associated with decreased upper-lower segment ratio. Low serum calcium (p=0.009), high serum phosphate (p=0.04) and impaired fasting glucose (p=0.004) were associated with BMI z-score below -2SD for age. Conclusions: Anthropometry abnormalities, including short stature, abnormal upper-lower segment ratio and low BMI, are common in TDT children. However, no vertebral abnormality was found in this study. Routine screening program by multidisciplinary team approach should be applied in thalassemia children.Keywords: Thalassemia major, endocrinopathies, growth failure, short stature, body disproportion

Sign in / Sign up

Export Citation Format

Share Document