scholarly journals Primary Intraosseous Squamous Cell Carcinoma Arising from a Dentigerous Cyst of the Maxillary Wisdom Tooth

2020 ◽  
Vol 13 (2) ◽  
pp. 611-616 ◽  
Author(s):  
Hikaru Takahashi ◽  
Yuichiro Takaku ◽  
Ayako Kozakai ◽  
Hiroshi Otsuru ◽  
Yuya Murata ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dentigerous Cyst ◽  
World Health ◽  
Histopathological Diagnosis ◽  
Wisdom Tooth ◽  
Early Stages ◽  
Health Organization ◽  
The Right

The World Health Organization defines primary intraosseous squamous cell carcinoma (PIOSCC) as a squamous cell carcinoma (SCC) arising primarily within the jaws and having no connection with the oral mucosa. Here, we report a case of PIOSCC in which it was difficult to differentiate the condition from pericoronitis of an impacted maxillary wisdom tooth. The patient was a 27-year-old pregnant woman with a pain in the right maxillary wisdom tooth. The pain was diagnosed as pericoronitis of the right maxillary wisdom tooth, and the tooth was extracted under local anesthesia. During extraction, soft tissue was observed in the coronal part of the tooth, and it was diagnosed as SCC arising in a dentigerous cyst. Because the tumor may still be present, surgical resection was performed under general anesthesia. There has been no recurrence or metastasis at the 1-year follow-up. This case was histopathologically considered from being a benign odontogenic tumor to a malignant tumor. However, it revealed an extensive aberrant type and invasion equivalent to SCC. Thus, the histopathological diagnosis was PIOSCC arising from a dentigerous cyst. Although advanced cases of PIOSCC have been published, diagnosis of PIOSCC in the early stages is rare. In this case, we diagnosed pericoronitis of an impacted maxillary wisdom tooth and extracted the tooth. Therefore, we discovered it accidentally. In the early stages, diagnosis can be difficult both clinically and histopathologically.

scholarly journals Incorporation of differentiated dysplasia improves prediction of oral leukoplakia at increased risk of malignant progression

2020 ◽  
Vol 33 (6) ◽  
pp. 1033-1040 ◽  
Author(s):  
Leon J. Wils ◽  
Jos B. Poell ◽  
Ilkay Evren ◽  
Marit S. Koopman ◽  
Elisabeth R. E. A. Brouns ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
World Health Organization ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Malignant Progression ◽  
Oral Leukoplakia ◽  
World Health ◽  
Oral Lesions ◽  
Health Organization

AbstractOral leukoplakia is the most common oral potentially malignant disorder with a malignant transformation rate into oral squamous cell carcinoma of 1–3% annually. The presence and grade of World Health Organization defined dysplasia is an important histological marker to assess the risk for malignant transformation, but is not sufficiently accurate to personalize treatment and surveillance. Differentiated dysplasia, known from differentiated vulvar intraepithelial neoplasia, is hitherto not used in oral dysplasia grading. We hypothesized that assessing differentiated dysplasia besides World Health Organization defined (classic) dysplasia will improve risk assessment of malignant transformation of oral leukoplakia. We investigated a retrospective cohort consisting of 84 oral leukoplakia patients. Biopsies were assessed for dysplasia presence and grade, and the expression of keratins 13 (CK13) and 17, known to be dysregulated in dysplastic vulvar mucosa. In dysplastic oral lesions, differentiated dysplasia is as common as classic dysplasia. In 25 out of 84 (30%) patients, squamous cell carcinoma of the upper aerodigestive tract developed during follow-up. Considering only classic dysplasia, 11 out of 56 (20%) patients with nondysplastic lesions progressed. With the incorporation of differentiated dysplasia, only 2 out of 30 (7%) patients with nondysplastic lesions progressed. The risk of progression increased from 3.26 (Hazard ratio, p = 0.002) when only classic dysplasia is considered to 7.43 (Hazard ratio, p = 0.001) when classic and differentiated dysplasia are combined. Loss of CK13, combined with presence of dysplasia, is associated with greater risk of malignant progression (p = 0.006). This study demonstrates that differentiated dysplasia should be recognized as a separate type of dysplasia in the oral mucosa and that its distinction from classic dysplasia is of pathological and clinical significance since it is a strong (co)prognostic histopathological marker for oral malignant transformation. In oral lesions without dysplasia and retained CK13 staining the risk for progression is very low.

scholarly journals Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Suna Avcı ◽  
Fatih Selcukbiricik ◽  
Ahmet Bilici ◽  
Gülkan Özkan ◽  
Ayse Ayşim Özağarı ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Complication ◽  
Cystic Teratoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Mature Cystic Teratoma ◽  
Histopathological Diagnosis ◽  
The Right

Introduction. Malignant transformation in a mature cystic teratoma of the ovary is a rare complication. Squamous cell carcinoma is the most common transformation. We describe a new case of squamous cell carcinoma arising in a mature cystic teratoma.Case Report. A premenopausal 52-year-old female patient is diagnosed with vaginal bleeding. According to examination made on the women and the pelvic scanning, 7 cm mass is found on the right adnexa of the patient. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic lymph node dissection, and debulking were the treatments completed on the patient. According to histopathological diagnosis, squamous cell carcinoma arising in a mature cystic teratoma is diagnosed as a reason for the mass in the right adnexa of the patient.Conclusion. The prognosis of the malign transformation of MCT depends on surgery stage; however it is extremely poor. The patient should receive chemotherapy regardless of stage. We have decided to administer second cycle carboplatin and paclitaxel treatments on the patient.

scholarly journals Giant peripheral ossifying fibroma with coincidental squamous cell carcinoma: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Takeshi Karube ◽  
Kanako Munakata ◽  
Yuka Yamada ◽  
Yuta Yasui ◽  
Shosuke Yajima ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fibrous Tissue ◽  
Tumor Resection ◽  
Ossifying Fibroma ◽  
Histopathological Diagnosis ◽  
Hard Tissue ◽  
Peripheral Ossifying Fibroma ◽  
The Right

Abstract Background Peripheral ossifying fibroma is an inflammatory or reactive hyperplasia of the gingiva that is usually small. It is formed by hard tissue in fibrous tissue, and the name “neoplastic lesion” has tended to be used frequently in Europe and America. Clinically, peripheral ossifying fibromas are painless, solitary, exophytic, sessile, or pedunculated and more frequently found in females than in males. To the best of our knowledge, there have been no reports of malignant cases. We herein report the case of giant peripheral ossifying fibroma with squamous cell carcinoma. Case presentation The patient was an 83-year-old Japanese woman who visited our hospital with a gingival massive mass. She was referred to us for an examination and treatment because it was difficult to perform tracheal intubation for surgery of sigmoid colon cancer at another hospital. The mass measured 83 × 58 × 35 mm, and it protruded to the extra-oral region from the right maxillary premolar alveolar region. Panoramic X-ray revealed the shadow of the mass in the right maxillary premolar region, which included some hard tissue. Computed tomography showed scattering calcified images in the mass. Magnetic resonance imaging was not performed because she had vertebral artery clips and screws in her forehead. Given the above findings, we performed a biopsy under local anesthesia. However, we were unable to diagnose absolutely whether the dysplastic squamous epithelia were pseudocarcinomatous hyperplasia of the gingiva or well-differentiated squamous cell carcinoma. Therefore, tumor resection was performed under general anesthesia. The histopathological diagnosis was peripheral ossifying fibroma with coincidental squamous cell carcinoma. There have been no signs of recurrence during follow-up as of 2 years after surgery. Conclusions The etiology of giant peripheral ossifying fibroma with squamous cell carcinoma is still not definite. Therefore, careful observation is necessary. It needs to be examined by accumulation of more cases in the future. We herein report the case of giant peripheral ossifying fibroma coincidental squamous cell carcinoma.

scholarly journals Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria

2015 ◽  
Vol 140 (4) ◽  
pp. 312-317 ◽  
Author(s):  
Brandon R. Driver ◽  
Bryce P. Portier ◽  
Dina R. Mody ◽  
Michael Deavers ◽  
Eric H. Bernicker ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
World Health ◽  
Mutation Profile ◽  
Nonkeratinizing Squamous Cell Carcinoma ◽  
Health Organization ◽  
Squamous Cell Carcinoma Group

The classification of pulmonary large cell carcinoma has undergone a major revision with the recent World Health Organization (WHO) 2015 Classification. Many large cell carcinomas are now reassigned to either adenocarcinoma with solid pattern or nonkeratinizing squamous cell carcinoma based on immunopositivity for adenocarcinoma markers or squamous cell carcinoma markers, respectively. Large cell carcinomas that are negative for adenocarcinoma and squamous cell carcinoma immunomarkers are now classified as large cell carcinoma with null immunohistochemical features (LCC-N). Although a few studies investigated the mutation profile of large cell carcinomas grouped by immunostain profile before the publication of the new WHO classification, investigation of tumors previously diagnosed as large cell carcinoma and reclassified according to the 2015 WHO classification has not, to our knowledge, been reported.Context.— To determine the mutation profiles of pulmonary large cell carcinomas reclassified by WHO 2015 criteria.Objective.— Archival cases of non–small cell lung carcinoma with large cell carcinoma morphology (n = 17) were reclassified according to 2015 WHO criteria. To determine mutation profile, we employed Ion Torrent (Life Technologies, Carlsbad, California)–based next-generation sequencing (50 genes; more than 2800 mutations) in addition to real-time quantitative reverse transcription polymerase chain reaction for ALK translocation detection.Design.— Two of 17 cases (12%) were reclassified as LCC-N, and both had mutations—BRAF D594N in one case and KRAS G12C in the other case. Seven of 17 cases (41%) were reclassified in the adenocarcinoma with solid pattern group, which showed one KRAS G12C and one EGFR E709K + G719C double mutation in addition to mutations in TP53. Eight of 17 cases (47%) were reclassified in the nonkeratinizing squamous cell carcinoma group, which showed mutations in PIK3CA, CDKN2A, and TP53. No ALK translocations or amplifications were detected.Results.— The adenocarcinoma with solid pattern group showed mutations typical of adenocarcinoma, whereas the nonkeratinizing squamous cell carcinoma group showed mutations typical of squamous cell carcinoma. Both LCC-N cases had mutations associated with adenocarcinoma, supporting the hypothesis that LCC-N is related to adenocarcinoma.Conclusions.—

scholarly journals Lesão maligna em lábio: do diagnóstico ao tratamento

2020 ◽  
Vol 8 (9) ◽  
Author(s):  
Taynara Sayuri Galdino Novaes ◽  
Rodolfo Pollo Soares ◽  
Aline Reis Stefanini ◽  
Luciana Estevam Simonato
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
World Health Organization ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rio De Janeiro ◽  
World Health ◽  
Lower Lip ◽  
Carcinoma Epidermoide ◽  
Health Organization

O carcinoma epidermóide em lábio representa cerca de 15% de todas as neoplasias em região de cabeça e pescoço e é responsável por cerca de 25% de todas as neoplasias malignas em cavidade oral. Em geral, se manifesta no lábio inferior e 90% dos casos acontecem no sexo masculino, 5:1 em relação ao sexo feminino. A raça branca é mais acometida, sendo comum na 5° e 6° décadas de vida e raro em crianças. São considerados fatores de risco exposição à radiação solar, tabagismo e etilismo. O câncer de lábio apresenta um bom prognóstico, desde que tratado adequadamente. Este trabalho visou apresentar um caso clínico de carcinoma epidermóide em lábio inferior, abordando os diagnósticos e terapêuticos, com a intenção de propagar informação de tal lesão para a classe odontológica.Descritores: Neoplasias; Carcinoma de Células Escamosas; Diagnóstico Bucal.ReferênciasBrener S, Jeunon FA, Barbosa AA, Grandinetti HAM. Carcinoma de células escamosas bucal: uma revisão de literatura entre o perfil do paciente, estadiamento clínico e tratamento proposto. Rev Bras Cancerol. 2007;53(1):63-9.Brasil. Instituto Nacional de Câncer. Incidência de câncer no Brasil. Rio de Janeiro: INCA; 2018.Antunes AA, Takano JH, Queiroz, TC, Vidal, AKL. Perfil epidemiológico do câncer bucal no CEON/HUOC/UPE e HCP. Odontol Clín Cient. 2003;2(3):183-86.Neville BW, Allen CM, Damm DD. Patologia e maxilofacial. 4. ed. Rio de Janeiro: Guanabara Koogan; 2016.Abdo EM, Garrocho AA, Aguiar MCF. Perfil do paciente portador de carcinoma epidermóide da cavidade bucal, em tratamento no Hospital Mário Penna em Belo Horizonte. Rev Bras Cancerol. 2002; 48(3):357-62.Warnakulasuriya KA, Johnson NW. Dentists and oral cancer prevention in the UK: opinion attitudes and practices to screening for muco lesions and to counseling patients on tobacco alcohol use: baseline data from 1991. Oral Dis. 1999;5(1):10-4.Oliveira LR, Silva AR, Zucoloto S. Perfil da incidência e da sobrevida de pacientes com carcinoma epidermóide oral em uma população brasileira. J Bras Patol Med Lab. 2006;42(1):385-92.Salgarelli AC, Sartorelli F, Cangiano A, Pagani R, Collini M. Surgical treatment of lip cancer: our experience with 106 cases. J Oral Maxillofac Surg. 2009;67(4):840-45.Tommasi AF, Tommasi MHM. Diagnóstico em patologia bucal. 4. ed. Rio de Janeiro: Elsevier;2014.Vidal AKL, Caldas Júnior AF, Mello RJV, Brandão VRA, Rocha GI, Taromaru E. HPV detection in oral carcinomas. J Bras Patol Med Lab. 2004;40(1):21-6.Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002;52(4):195-215.Costa ALL, Araújo-Júnior RF, Ramos CCF. Correlação entre a classificação clínica TNM e as características histológicas de malignidade do carcinoma epidermóide oral. Rev Bras Otorrinolaringol. 2005;71(2):181-87.Dedivitis RA, França CM, Mafra ACB, Guimarães FT, Guimarães AV. Características clínicoepidemiológicas no carcinoma espinocelular de boca e orofaringe. Rev Bras Otorrinolaringol. 2004;70(1):35-40.Ochsenius G, Ormeno A, Godoy L, Rojas R. Estúdio retrospectivo de 232 casos de câncer y precáncer de lábio en pacientes chilenos. Correlación clínicohistológica. Rev méd Chile. 2003;131(1):60-6.Antunes AA, Antunes AP. Estudo retrospectivo e revisão de literatura dos tumores dos lábios: experiência de 28 anos. Rev Bras Cancerol. 2004;50(4):295-300.Sena MF, Costa APS, Nóbrega AGS, Costa ALL, Ferreira MAF. Avaliação dos fatores prognósticos relacionados ao câncer de lábio: revisão sistemática. Rev Bras Cancerol. 2010;56(1):93-102.Bittencourt R, Scaletzky A, Boehl JAR. Perfil epidemiológico do câncer na rede pública em Porto Alegre - RS. Rev Bras Cancerol. 2004;50(2):95-101.Perussi MR, Denardin OVP, Fava AS, Rapoport A. Carcinoma epidermóide da boca em idosos de São Paulo. Rev Assoc Med Bras. 2002; 48(4):341-44.Guerra MR, Gallo CVM, Mendonça GAS. Risco de câncer no Brasil: tendências e estudos epidemiológicos mais recentes. Rev Bras Cancerol. 2005;51(3):227-34.Carvalho MB, Lenzi J, Lehn CN, Fava AS, Amar A, Kanda JL et al. Características clínico-epidemiológicas do carcinoma epidermóide de cavidade oral no sexo feminino. Rev Assoc Med Bras. 2001;47(3):208-14.Instituto Nacional de Câncer (Brasil). Prevenção do câncer da boca. Rio de Janeiro: INCA; 2016.Chandu A, Adams G, Smith AC. Factors affecting survival in patients with oral cancer: an Australian perspective. Int J Oral Maxillofac Surg. 2005.34(5):514-20.World Health Organization (Switzerland). World Health Organization Classification of Tumours. Pathology & Genetics Head and Neck Tumours. Geneva: IARC Press; 2005; 242-3.Onercl M, Yilmaz T, Gedikoglu G. Tumor thickness as a predictor of cervical lymph node metastasis in squamous cell carcinoma of the lower lip. Otolaryngol Head Neck Surg. 2000;122(1):139-42.Costa ALL, Pereira JC, Nunes AAF, Arruda MLS. Correlação entre a classificação TNM, gradação histological e localização anatômica em carcinoma epidermóide oral. Pesqui Odontol Bras. 2002; 16(3):216-20.Sciubba JJ. Oral cancer and its early detection: historytaking and the diagnostic phase management. J Am Dent Assoc. 2001;132(Suppl):12S-18S.Llewellyn CD, Johnson NW, Warnakulasuriya KAAS. Risk factors for squamous cell carcinoma of the oral cavity in young people – a comprehensive literature review. Oral Oncol. 2001;37(5):401-18.

scholarly journals Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification

2020 ◽  
Vol 27 (6) ◽  
pp. R177-R192 ◽  
Author(s):  
Alfred King-yin Lam
Keyword(s):  
Squamous Cell Carcinoma ◽  
World Health Organization ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
World Health ◽  
Primary Squamous Cell Carcinoma ◽  
World Health Organization Classification ◽  
Unique Type ◽  
Health Organization

The aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of the World Health Organization classification of endocrine tumours. The carcinomas occur in 83 women and 34 men (female to male ratio is 2.4 to 1) and with median age at presentation of 64. Half of these squamous cell carcinomas of thyroid were moderately differentiated. PAX-8 protein is a sensitive marker for confirming the thyroid origin of the carcinoma. The carcinoma is also positive for p63, p40, cytokeratins 5/6, 7,19 and negative for cytokeratins 20 and 10/13. P53 overexpression is common. The most important differential diagnosis is direct infiltration or metastatic involvement by squamous cell carcinoma from other organs. Limited mutation analysis revealed BRAF mutation in some squamous cell carcinomas of the thyroid. The genetic profile appears to be different from anaplastic thyroid carcinomas. Primary squamous cell carcinoma of thyroid had lymph node involvement in 59% and distant metastases in 26%. The median survival of the patients was 8 months. Curative surgery offers the best survival for the patients with the carcinoma. To conclude, primary squamous cell carcinoma of the thyroid gland has distinctive clinical, pathological and molecular profiles. It is important to recognize this unique variant of thyroid carcinoma for possible curative surgical resection and to do more genomic works on the entity to uncover the molecular pathogenesis.

scholarly journals Chromoblastomycosis evolving to sarcomatoid squamous cell carcinoma: A case report

2021 ◽  
Vol 13 (2) ◽  
Author(s):  
Walter Belda Jr. ◽  
Paulo Ricardo Criado ◽  
Paula Casteleti ◽  
Luiz Felipe Domingues Passero
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neoplastic Transformation ◽  
World Health ◽  
Dematiaceous Fungi ◽  
Present Case Report ◽  
Cutaneous Fungal Infection ◽  
Health Organization

Chromoblastomycosis (CMB) is a cutaneous fungal infection caused by dematiaceous fungi. According to the World Health Organization CMB has been elected as a tropical disease, and it is prevalent in tropical and subtropical regions. The lower extremities are the most affected areas, and the lesions progress with erythema, papules, nodules, verrucose plates and/or ulcerations. So far, few works have demonstrated neoplastic transformation in chronic CMB lesions, and it may be a consequence of prolonged inflammatory response. In the present case report, we described a neoplastic transformation from CMB lesion of a 55- year-old man, presenting lesions only in the left leg for 35 years. After treatment, a verrucous white plate with thick and irregular borders emerged in the ankle, which was identified as a sarcomatoid squamous cell carcinoma. The present case report highlights the importance of an early diagnosis and treatment.

scholarly journals Squamous cell carcinoma mimics small cell carcinoma of the lung: a case report

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Michael Kmeid ◽  
Breanne Gillie ◽  
Armand Asarian ◽  
Philip Xiao
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Tumors ◽  
Small Cell ◽  
World Health ◽  
Lung Cancers ◽  
Lung Carcinomas ◽  
The Usa ◽  
Health Organization

Abstract Squamous cell carcinomas (SCC) accounts for roughly 20% of lung cancers in the USA. The 2015 World Health Organization classification of lung tumors further categorizes SCC as three subtypes: keratinizing, non-keratinizing and basaloid variant. The non-keratinizing subtype is a poorly differentiated tumor that can present histologically in different ways, and one of which is a rare variant that strongly resembles small cell carcinoma. As a result, histological diagnosis alone is not sufficient to properly diagnose lung carcinomas. Immunohistochemistry has been increasingly used over the past few years to differentiate between lung tumors. The combination of morphological and immunohistochemical staining should be the mainstay for diagnosis of all lung carcinomas as more targeted therapies become more available.

scholarly journals Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

2021 ◽  
Vol 7 ◽  
pp. 2513826X2110084
Author(s):  
Weston Thomas ◽  
Kevin Rezzadeh ◽  
Kristie Rossi ◽  
Ajul Shah
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Skin Graft ◽  
Donor Site ◽  
Skin Grafting ◽  
Excisional Biopsy ◽  
Graft Donor ◽  
The Right

Introduction: Skin graft reconstruction is a common method of providing wound coverage. Rarely, skin grafting can be associated with the development of squamous cell carcinoma (SCC) in the graft donor site. Case Report: The patient is a 72-year old male with a 15-year history of bilateral hip wounds. He underwent a multitude of treatments previously with failed reconstructive efforts. After presenting to us, he underwent multiple debridements and eventual skin grafting. Within 4 weeks of the final skin graft, a mass developed at the skin graft donor site at the right thigh. Excisional biopsy returned a well differentiated keratinizing SCC. Discussion/Conclusion: This case demonstrates the acute presentation of SCC in a patient following a skin graft without known risk factors. The purpose of this unique case report is to highlight a very rare occurrence of SCC at a skin graft donor site.

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