scholarly journals A Case of Dermatomyositis Coexisting with Both Anti-Mi-2 and Anti-NXP-2 Antibodies

2020 ◽  
Vol 12 (2) ◽  
pp. 92-97
Author(s):  
Mitsuru Ito ◽  
Chie Moriya ◽  
Kanako Matsuyama ◽  
En Shu ◽  
Yasuhito Hamaguchi ◽  
...  
Keyword(s):  
Rare Case ◽  
Matrix Protein ◽  
Clinical Phenotype ◽  
Skin Lesions ◽  
The Other ◽  
Severe Phenotype ◽  
Nuclear Matrix Protein ◽  
Peripheral Edema ◽  
Internal Malignancy ◽  
Typical Skin

Myositis-specific autoantibodies (MSAs) including anti-Mi-2 and anti-nuclear matrix protein 2 (NXP-2) antibodies have been detected in the patients with dermatomyositis (DM), and are useful tools for identifying clinical subsets of DM. MSAs are exclusively found in DM patients. Anti-Mi-2 antibody-positive DM patients show the typical skin lesions and myositis and are rarely associated with internal malignancy and interstitial lung disease (ILD). On the other hand, adult DM patients with anti-NXP-2 antibody often show calcinosis and internal malignancy, but rarely ILD. In addition, anti-NXP-2 antibody-positive DM patients have severe phenotype with myalgia, peripheral edema, and significant dysphagia, but with mild skin lesions. Herein, we report a rare case of classic DM coexisting with both anti-Mi-2 and anti-NXP-2 antibodies, clinically, without ILD or internal malignancy. Our patient had typical skin manifestations, muscle weakness, muscle pain, and general fatigue without calcinosis, peripheral edema, or dysphagia. Thus, the clinical phenotype was similar to anti-Mi-2 antibody-positive DM.

scholarly journals Dermatomyositis-specifikus autoantitesttel rendelkező és autoantitest-negatív betegeink klinikai jellemzőinek és laboratóriumi paramétereinek összehasonlítása

2015 ◽  
Vol 156 (36) ◽  
pp. 1451-1459 ◽  
Author(s):  
Levente Bodoki ◽  
Dóra Budai ◽  
Melinda Nagy-Vincze ◽  
Zoltán Griger ◽  
Zoe Betteridge ◽  
...  
Keyword(s):  
Muscle Weakness ◽  
Matrix Protein ◽  
Skin Lesions ◽  
Clinical Findings ◽  
Proximal Muscle Weakness ◽  
Proximal Muscle ◽  
Nuclear Matrix Protein ◽  
Specific Antibodies ◽  
Antibody Positivity ◽  
Specific Autoantibody

Introduction: Myositis is an autoimmune disease characterised by proximal muscle weakness. Aim: The aim of the authors was to determine the frequency of dermatomyositis-specific autoantibodies (anti-Mi-2, anti-transcriptional intermediary factor 1 gamma, anti-nuclear matrix protein 2, anti-small ubiquitin-like modifier activating enzyme, anti-melanoma differentiation-associated gene) in a Hungarian myositis population and to compare the clinical features with the characteristics of patients without myositis-specific antibodies. Method: Antibodies were detected using immunoblot and immunoprecipitation. Results: Of the 330 patients with nyositis, 48 patients showed dermatomyositis-specific antibody positivity. The frequency of antibodies in these patients was lower than those published in literature Retrospective analysis of clinical findings and medical history revealed that patients with dermatomyositis-specific autoantibody had more severe muscle weakness and severe skin lesions at the beginning of the disease. Conclusions: Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy. Orv. Hetil., 2015, 156(36), 1451–1459.

scholarly journals A rare case of NXP-2 positive dermatomyositis

2020 ◽  
Vol 7 (4) ◽  
pp. 68-71
Author(s):  
Nariman Khan ◽  
Keyword(s):  
Muscle Weakness ◽  
Nuclear Matrix ◽  
Conventional Therapy ◽  
Rare Case ◽  
Matrix Protein ◽  
Inflammatory Myopathy ◽  
Idiopathic Inflammatory Myopathy ◽  
Nuclear Matrix Protein ◽  
Cutaneous Manifestations ◽  
Distal Muscle

Dermatomyositis is an idiopathic inflammatory myopathy with variable cutaneous manifestations. Several autoantibodies each with distinct clinical phenotypes are associated with the disease. Here we present the case of a 36-year-old Laotian woman with hypothyroidism who presented with severe proximal and distal muscle weakness, dysphagia, diffuse rash, and anasarca that was diagnosed with NXP-2 (nuclear matrix protein 2) antibody positive dermatomyositis. The patient’s hospitalization was complicated by disease resistant to conventional therapy.

984: Variability in the Performance of Nuclear Matrix Protein 22 in the Detection of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 317-317
Author(s):  
Shahrokh F. Shariat ◽  
Michael Marberger ◽  
Yair Lotan ◽  
Marta Sanchez-Carbayo ◽  
Craig D. Zippe ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein

Sa1664 Identification of Nuclear Matrix Protein Alternations Associated With Autophagic Dysfunction in the Liver

2016 ◽  
Vol 150 (4) ◽  
pp. S1090
Author(s):  
Shunhei Yamashina ◽  
Kousuke Izumi ◽  
Yoshihiro Inami ◽  
Tomonori Aoyama ◽  
Akira Uchiyama ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein

hNMP 200: A Novel Human Common Nuclear Matrix Protein Combining Structural and Regulatory Functions

2000 ◽  
Vol 261 (1) ◽  
pp. 166-179 ◽  
Author(s):  
Josef Gotzmann ◽  
Christopher Gerner ◽  
Michael Meissner ◽  
Klaus Holzmann ◽  
Rudolf Grimm ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Regulatory Functions

scholarly journals The Nuclear Matrix Protein CDP Represses Hepatic Transcription of the Human Cholesterol-7α Hydroxylase Gene

2000 ◽  
Vol 275 (34) ◽  
pp. 26649-26660 ◽  
Author(s):  
Travis J. Antes ◽  
Jean Chen ◽  
Allen D. Cooper ◽  
Beatriz Levy-Wilson
Keyword(s):  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Hydroxylase Gene

Diagnostic accuracy of NMP-52, NMP-22 and urine cytology in the diagnosis of bladder cancer

2021 ◽  
Vol 16 (10) ◽  
pp. 59-62
Author(s):  
Mohamed J. Saadh
Keyword(s):  
Bladder Cancer ◽  
Nuclear Matrix ◽  
Diagnostic Performance ◽  
Matrix Protein ◽  
Urinary Cytology ◽  
Significant Relation ◽  
Nuclear Matrix Protein ◽  
Diagnostic Efficacy ◽  
Noninvasive Biomarkers ◽  
New Biomarkers

Bladder cancer (BC) is the most important tumor problem of urologic cancer. Therefore, noninvasive urinary biomarkers were used for diagnosis of BC. However, the new biomarkers failed to reach higher accuracy. The aim of this study was to assess the diagnostic efficacy of nuclear matrix protein-22 (NMP- 22), nuclear matrix protein-52 (NMP-52), urinary cytology and to investigate combinations of urine NMP-52 with urinary cytology as noninvasive biomarkers to increase diagnostic performance of bladder cancer at different grades and stages. Overall, there were 156 subjects (62 BC, 54 cystitis patients and 40 healthy volunteers). The NMP-22 and NMP-52 were quantified in urine samples by ELISA. The urinary cytology is used by some physicians routinely for diagnosis of BC. The sensitivity and specificity for NMP-52 were 94% and 82%, for NMP-22 69% and 80.8% and for cytology 56% and 94.6% respectively and also, both urinary NMP-22 and NMP-52 have extremely significant relation (p<0.0001) to BC vs. healthy individuals and cystitis patients. Moreover, the combination of NMP- 52 with urinary cytology could predict all BC stages and grade with 95.6% sensitivity and 94.3% specificity. In conclusion, NMP-52 and urinary cytology in combination improve diagnostic performance for BC detection in different pathological types.

scholarly journals Bilateral Sturge Weber Syndrome- a rare case report

2013 ◽  
Vol 5 (1) ◽  
pp. 129-132 ◽  
Author(s):  
P Singh ◽  
S Singh
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Unusual Case ◽  
The Other ◽  
Advanced Stage ◽  
Weber Syndrome ◽  
Rare Case Report ◽  
The Face ◽  
Bilateral Condition ◽  
Sturge Weber Syndrome

Background: Sturge-Weber syndrome is a rare congenital neuro- oculo- cutaneous disorder. Objective: To report a very rare unusual case of bilateral manifestation of Sturge Weber syndrome. Case: We report an unusual case of a 17-year-old female with advanced stage of bilateral glaucoma associated with facial nevus extending to the other half of the face as well and bilateral intracranial calcification. Conclusion: Sturge -Weber syndrome can manifest as a bilateral condition. Nepal J Ophthalmol 2013; 5(9):129-132 DOI: http://dx.doi.org/10.3126/nepjoph.v5i1.7841

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