scholarly journals Case Report: Fibroglial Retinal Tissue in Contractile Morning Glory Disc Anomaly

2021 ◽  
pp. 525-530
Author(s):  
Abel Ramirez-Estudillo ◽  
Karla Torres-Navarro ◽  
Sergio Rojas-Juárez ◽  
Ximena Ramirez-Galicia ◽  
Berenice Palafox-Cornejo ◽  
...  
Keyword(s):  
Structural Changes ◽  
Retinal Pigment ◽  
Anterior Segment ◽  
Posterior Pole ◽  
Retinal Pigment Epithelial Cells ◽  
Morning Glory ◽  
Retinal Tissue ◽  
Morning Glory Disc Anomaly ◽  
History Of ◽  
Pars Plana

The purpose of the present case is to describe a patient with tractional retinal detachment (RD) associated with contractile morning glory: a 17-year-old female, with a history of failed surgery for RD when she was 2 years old in her right eye (OD), nystagmus, and a limited visual acuity in the left eye (OS). The slit lamp examination showed phthisis bulbi in OD and the anterior segment was unremarkable in OS. Dilated fundus examination revealed a tractional RD in the posterior pole and peripapillary and preretinal fibrosis without evidence of intravitreal dispersion of retinal pigment epithelial cells. After surgery treatment, the RD resolved and the posterior segment showed a staphylomatous excavation around the optic disc anomaly with irregular contractions that folded the macular area. This were unrelated to light, breathing, or eye movements. Although morning glory disc anomaly is associated with RD, the early diagnosis can reverse structural changes. In this case, the rare association with contractile movements was found posterior to the pars plana vitrectomy after all the fibroglial epiretinal tissue was removed.

Morning glory disc anomaly-associated maculopathy: multimodal imaging

2021 ◽  
Vol 14 (1) ◽  
pp. e237462
Author(s):  
Inae Hwang ◽  
Marta Ugarte
Keyword(s):  
Multimodal Imaging ◽  
Fluid Pressure ◽  
Morphological Characteristics ◽  
Posterior Pole ◽  
Morning Glory ◽  
Fluid Accumulation ◽  
Tomography Imaging ◽  
Morning Glory Disc Anomaly ◽  
Optical Coherence Tomography Imaging ◽  
The Right

Morning glory disc anomaly (MGDA) is most commonly found in white females in childhood with reduced vision. One in two cases have been reported to develop maculopathy or posterior pole retinal detachment as they grow older. The pathophysiology of MGDA-associated maculopathy is not well understood.We describe a 31-year-old black woman, who presented with gradual reduction of vision in the right eye due to MGDA-associated maculopathy. We identified morphological characteristics of the optic disc and macula with multicolour and optical coherence tomography imaging.We speculate that the centripetal inner retina traction and cerebrospinal fluid pressure fluctuation play an important role in inner retinal fluid accumulation in the pathology of retinoschisis in MGDA. Further studies will shed some light of a potential cause-and-effect relationship between MGDA and retinoschisis.

scholarly journals A Rare Case of Unilateral Morning Glory Disc Anomaly in a Patient with Turner Syndrome: Report and Review of Posterior Segment Associations

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Dev R. Sahni ◽  
Michael Wallace ◽  
Mansi Kanhere ◽  
Hind Al Saif ◽  
Natario Couser
Keyword(s):  
Turner Syndrome ◽  
Sex Chromosome ◽  
Anterior Segment ◽  
Clinical Manifestations ◽  
Morning Glory ◽  
Structural Abnormality ◽  
Partial Loss ◽  
Rare Presentation ◽  
Morning Glory Disc Anomaly ◽  
Chromosome Disorder

Turner syndrome is a common sex chromosome disorder affecting females. The disorder is caused by a partial loss, complete absence, or structural abnormality of one X chromosome. The clinical presentation is broad and ranges from the classic phenotype to minimal clinical manifestations. Ocular abnormalities associated with the syndrome are common. Reports describing abnormal eye features in individuals with Turner syndrome generally involve refractive errors (myopia or hyperopia), strabismus, and external or anterior segment abnormalities including hypertelorism, epicanthal folds, and ptosis. Posterior ocular segment anomalies involving the optic nerve and retina in Turner syndrome have been rarely reported. We report a rare presentation of an 11-year-old female with Turner syndrome and unilateral morning glory disc anomaly.

Cytoprotective effect of crocin and trans-resveratrol on photodamaged primary human retinal pigment epithelial cells

2019 ◽  
pp. 112067211989596
Author(s):  
Stefan Kassumeh ◽  
Christian M Wertheimer ◽  
Andreas Ohlmann ◽  
Siegfried G Priglinger ◽  
Armin Wolf
Keyword(s):  
Epithelial Cells ◽  
Pars Plana Vitrectomy ◽  
Retinal Pigment Epithelial ◽  
Light Exposure ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pigment Epithelial ◽  
Pars Plana ◽  
Pigment Epithelial Cells

Purpose: Light-induced damage to retinal pigment epithelium during pars plana vitrectomy remains a hot topic in ophthalmology. Improvements in technology led to a change of light sources, selective filters, and shorter light exposure time. Currently, there is no satisfying solution to the problem. The aim of the study was to investigate the cytoprotective effects of crocin and resveratrol on light-induced damage to primary human retinal pigment epithelial cells in vitro. Methods: Primary human retinal pigment epithelial cells were exposed to light analogous to the illumination during pars plana vitrectomy. To evaluate the cytoprotective effects and potential toxicity of resveratrol and crocin, human retinal pigment epithelial cells were incubated with varying concentrations of both before 3-[4,5-dimethylthiazol-2-yl] tetrazolium bromide (MTT) viability assay. Furthermore, glutathione levels were measured to investigate synergistic antioxidant potential. Apoptosis of human retinal pigment epithelial cells was determined by a nucleosome detection enzyme-linked immunosorbent assay. Results: Crocin and resveratrol improved cell viability in photodamaged human retinal pigment epithelial cells significantly from 40.65 ± 21.99% in illuminated human retinal pigment epithelial cells and reached a peak viability of 85.64 ± 11.37% in crocin and resveratrol pretreated cells (for all: p < 0.001). In line, the combination of the supplements increased glutathione levels significantly from 39.35 ± 21.96% to 80.74 ± 10.32% ( p = 0.017). No toxic effects were detected ( p > 0.99). However, no change in apoptosis rates could be observed following pretreatment with crocin and resveratrol ( p > 0.99). Conclusion: Crocin and trans-resveratrol revealed cytoprotective effects on human retinal pigment epithelial cells supporting both supplement’s development as potential perioperative treatments in light-induced retinal pigment epithelial damage.

scholarly journals Ocular findings among patients surviving COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ílen Ferreira Costa ◽  
Livia Pimenta Bonifácio ◽  
Fernando Bellissimo-Rodrigues ◽  
Eduardo Melani Rocha ◽  
Rodrigo Jorge ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Pigment Epithelium ◽  
Demographic Data ◽  
Retinal Pigment ◽  
Anterior Segment ◽  
Posterior Pole ◽  
Architecture Evaluation ◽  
Severe Group ◽  
The Mean ◽  
The Right

AbstractTo describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonometry, break-up time and Schirmer tests, indirect ophthalmoscopy, color fundus picture, and retinal architecture evaluation using optical coherence tomography. Socio-demographic data and personal medical history were also collected. According to the severity of systemic manifestations, patients were classified into mild-to-moderate, severe, and critical. Sixty-four patients (128 eyes) were evaluated 82 ± 36.4 days after the onset of COVID’s symptoms. The mean ± SD duration of hospitalization was 15.0 ± 10.7 days. Seven patients (10.9%) had mild-to-moderate, 33 (51.5%) severe, and 24 (37.5%) critical disease. Median [interquartile ranges (IQR)] presenting visual acuity was 0.1 (0–0.2) and BCVA 0 (0–0.1). Anterior segment biomicroscopy was unremarkable, except for dry eye disease, verified in 10.9% of them. The mean ± SD intraocular pressure (IOP) in critical group (14.16 ± 1.88 mmHg) was significantly higher than in severe group (12.51 ± 2.40 mmHg), both in the right (p 0.02) and left eyes (p 0.038). Among all, 15.6% had diabetic retinopathy, and two patients presented with discrete white-yellowish dots in the posterior pole, leading to hyporreflective changes at retinal pigment epithelium level, outer segment, and ellipsoid layers. The present study identified higher IOP among critical cases, when compared to severe cases, and discrete outer retina changes 80 days after COVID-19 infection. No sign of uveitis was found.

Okuläre Symptome nach COVID-19-Infektion

2021 ◽  
pp. 1-3
Author(s):  
Katja Göbel
Keyword(s):  
Visual Acuity ◽  
Pigment Epithelium ◽  
Demographic Data ◽  
Retinal Pigment ◽  
Anterior Segment ◽  
Posterior Pole ◽  
Architecture Evaluation ◽  
Severe Group ◽  
The Mean ◽  
The Right

To describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonometry, break-up time and Schirmer tests, indirect ophthalmoscopy, color fundus picture, and retinal architecture evaluation using optical coherence tomography. Socio-demographic data and personal medical history were also collected. According to the severity of systemic manifestations, patients were classified into mild-to-moderate, severe, and critical. Sixty-four patients (128 eyes) were evaluated 82 ± 36.4 days after the onset of COVID’s symptoms. The mean ± SD duration of hospitalization was 15.0 ± 10.7 days. Seven patients (10.9%) had mild-to-moderate, 33 (51.5%) severe, and 24 (37.5%) critical disease. Median [interquartile ranges (IQR)] presenting visual acuity was 0.1 (0–0.2) and BCVA 0 (0–0.1). Anterior segment biomicroscopy was unremarkable, except for dry eye disease, verified in 10.9% of them. The mean ± SD intraocular pressure (IOP) in critical group (14.16 ± 1.88 mmHg) was significantly higher than in severe group (12.51 ± 2.40 mmHg), both in the right (p 0.02) and left eyes (p 0.038). Among all, 15.6% had diabetic retinopathy, and two patients presented with discrete white-yellowish dots in the posterior pole, leading to hyporreflective changes at retinal pigment epithelium level, outer segment, and ellipsoid layers. The present study identified higher IOP among critical cases, when compared to severe cases, and discrete outer retina changes 80 days after COVID-19 infection. No sign of uveitis was found.

scholarly journals Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging

2021 ◽  
Author(s):  
Michael Lekwuwa ◽  
Mayur Choudhary ◽  
Eleonora M. Lad ◽  
Goldis Malek
Keyword(s):  
Macular Degeneration ◽  
Vision Loss ◽  
Retinal Pigment ◽  
Posterior Pole ◽  
The Body ◽  
Retinal Pigment Epithelial Cells ◽  
Age Related Macular Degeneration ◽  
Calcium Deposition ◽  
Cellular Functions ◽  
Age Related

AbstractA common clinical phenotype of several neurodegenerative and systemic disorders including Alzheimer’s disease and atherosclerosis is the abnormal accumulation of extracellular material, which interferes with routine cellular functions. Similarly, patients with age-related macular degeneration (AMD), the leading cause of vision loss among the aged population, present with extracellular lipid- and protein-filled basal deposits in the back of the eye. While the exact mechanism of growth and formation of these deposits is poorly understood, much has been learned from investigating their composition, providing critical insights into AMD pathogenesis, prevention, and therapeutics. We identified human osteopontin (OPN), a phosphoprotein expressed in a variety of tissues in the body, as a newly discovered component of basal deposits in AMD patients, with a distinctive punctate staining pattern. OPN expression within these lesions, which are associated with AMD disease progression, were found to co-localize with abnormal calcium deposition. Additionally, OPN puncta colocalized with an AMD risk-associated complement pathway protein, but not with apolipoprotein E or vitronectin, two other well-established basal deposit components. Mechanistically, we found that retinal pigment epithelial cells, cells vulnerable in AMD, will secrete OPN into the extracellular space, under oxidative stress conditions, supporting OPN biosynthesis locally within the outer retina. Finally, we report that OPN levels in plasma of aged (non-AMD) human donors were significantly higher than levels in young (non-AMD) donors, but were not significantly different from donors with the different clinical subtypes of AMD. Collectively, our study defines the expression pattern of OPN in the posterior pole as a function of disease, and its local expression as a potential histopathologic biomarker of AMD.

scholarly journals A new combined surgical approach in a patient with microspherophakia and developmental iridocorneal angle anomaly

2015 ◽  
Vol 7 (1) ◽  
pp. 85-89 ◽  
Author(s):  
B Satana ◽  
C Altan ◽  
B Basarir ◽  
Z Alkin ◽  
OF Yilmaz
Keyword(s):  
Positive Family History ◽  
Anterior Segment ◽  
Anterior Segment Dysgenesis ◽  
Iridocorneal Angle ◽  
Horizontal Diameter ◽  
History Of ◽  
Pars Plana Lensectomy ◽  
Pars Plana ◽  
The Right

Backround: We describe a patient with microspherophakia due to Weill-Marchesani syndrome accompanied by developmental angle anomaly who was successfully treated with a surgery of combined PPL and goniotomy.Case: We report ocular findings of a 1-year-old girl who was diagnosed with Weill-Marchesani syndrome with a positive family history of glaucoma in her cousins and glaucoma with anterior segment dysgenesis in her older brother. Anterior segment examination revealed clear corneas with 13 mm horizontal diameter in the right and 12.5 mm in the left and very shallow anterior chambers centrally and peripherally in both eyes. Although axial lengths were 18.9 mm in the right and 19.1 mm in the left eye, cycloplegic refractive errors were -7.75 DS (-2.75 at 1800) in the right eye and -8.50 DS (-2,75 at 1800) in the left eye. Intraocular pressures were 34 mmHg in the right and 38 mmHg in the left eye.Observation: Following pars plana lensectomy, gonioscopy revealed developmental iridocorneal angle anomaly and goniotomy was performed at the same session. During 3 years of follow-up, the patient experienced no complications. IOP was 12 mmHg without medication in the last visit; cup-to-disc ratio and corneal diameters were stable. Conclusion: The coexistent microspherophakia and developmental iridocorneal angle anomaly can be successfully treated with combined pars plana lensectomy and goniotomy.

scholarly journals Management of Retinal Detachment Associated with Morning Glory Disc Syndrome

2021 ◽  
pp. 457-463
Author(s):  
Tyler Etheridge ◽  
Zackery Oakey ◽  
Michael M. Altaweel
Keyword(s):  
Retinal Detachment ◽  
Gene Mutation ◽  
Pars Plana Vitrectomy ◽  
Subretinal Fluid ◽  
Morning Glory ◽  
Pax6 Gene ◽  
Fluid Exchange ◽  
Tractional Retinal Detachment ◽  
Morning Glory Disc Anomaly ◽  
Pars Plana

We report a case of morning glory disc anomaly in a young patient with tractional retinal detachment successfully repaired with complex pars plana vitrectomy, membrane peel, laser, and oil tamponade. A 19-year-old female with a history of right morning glory disc anomaly associated with PAX6 gene mutation presented with floaters, photopsia, central scotoma, and visual acuity (VA) of 1/200. A complex macula-involving tractional retinal detachment centered around the optic nerve with a morning glory disc anomaly. Retinal detachment was treated with 25-gauge pars plana vitrectomy with difficult separation of the posterior hyaloid. Fibrous preretinal membranes were peeled, a temporal relaxing retinotomy was required, subretinal fluid was drained through a superonasal retinotomy during air-fluid exchange, endolaser was applied, and tamponade was achieved with 1,000-centistoke silicone oil. The retina remained attached at 1-year follow-up, with VA count fingers throughout. Morning glory disc is a rare congenital anomaly associated with PAX6 gene mutation that most often occurs unilaterally. It is rarely associated with tractional retinal detachment. Optimization of visual outcome is imperative despite a poor visual prognosis.

Rare presentation of choroidal neovascularisation in a case of congenital hypertrophy of retinal pigment epithelium

2021 ◽  
Vol 14 (9) ◽  
pp. e244554
Author(s):  
Ramesh Venkatesh ◽  
Nikitha Gurram Reddy ◽  
Ram Snehith Pulipaka ◽  
Arpitha Pereira
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Anterior Segment ◽  
Subretinal Fluid ◽  
Choroidal Neovascularisation ◽  
Rare Presentation ◽  
History Of ◽  
The Right ◽  
Congenital Hypertrophy

A 22-year-old woman presented with a 2-week history of decreased vision, a central scotoma and metamorphopsia in her right eye. Her presenting visual acuity was 6/75 in the right eye and 6/6 in the left eye. Anterior segment examination was normal. Fundus examination of both eyes showed features of bilateral congenital hypertrophy of retinal pigment epithelium (CHRPE) lesions and choroidal neovascularisation (CNV) in the right eye. She was treated with intravitreal injection bevacizumab 1.25 mg/0.05 mL. One month later, there was regression of the CNV and subretinal fluid and her vision improved to 6/12. At the final follow-up visit, her vision was maintained at 6/9 with regression of CNV noted. To conclude, CNV is a rare association of CHRPE. It can lead to vision-threatening problem if it involves the macula and should be identified promptly and managed appropriately.

Macular Electroretinography and Methods of Retina Visualization in Diagnostics of Standard Stargardt Disease, Verified by Molecular Genetic Methods

10.12737/2827 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-8
Author(s):  
Стрельников ◽  
V. Strelnikov ◽  
Рогова ◽  
S. Rogova ◽  
Егорова ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wave Amplitude ◽  
Structural Changes ◽  
Pigment Epithelium ◽  
Outer Nuclear Layer ◽  
Retinal Pigment ◽  
Molecular Genetic ◽  
Posterior Pole ◽  
Optical Coherence ◽  
Transverse Defect

The aim of the study was to assess the data concerning the modern methods of retina visualization (optical coherence tomography and autofluorescence) and its interrelation with the data concerning the modern elec-troretinographic methods for research of Stargardt desease, verified with the help of molecular genetic methods. It was found that the shift of macular electroretinogramm to the red stimulus correlates with the parameters of optic coherent tomography: inverse high correlation between the &#34;transverse defect&#34; and a-wave amplitude of macular electroretinogramm (r=-0,83, p&#60;0,01), thus indicating interconnection between lowering of photoreceptor function and structural changes of junction between outer and inner photoreceptor segments. Correlation between the &#34;transverse defect&#34; and b-wave amplitude of macular electroretinogramm (r=-0,37, p&#60;0,01) proves the existence of interrelation between electrogenesis of middle retina layers (bipolar cells) in fovea and biometrical markers of structural changes in photoreceptors caused by Stargardt desease. The hallmarks of Stargardt desease, revealed by the optical coherence tomography, are the hyperreflective spots, localized in retinal pigment epithelium and reaching the outer nuclear layer, together with the damaged interface line of the outer and inner photoreceptors segments. Autofluoresence caused by Stargardt desease demonstrates combination of hypofluorescence in fovea with hypofluorescence in the posterior pole. For the first time the following etiologic mutations of ABCA4 gene, associated with Stargardt desease were revealed in Russian population: rsl800553 (Glyl961Glu), rs61752418 (Aspl093Gly), rs61751374 (Alal038Val), rs201471607 (Asn965Ser), rsl801581 (Arg943Gln), rs75197161 (Gly863Ala delG863), rs76157638 (Arg653Cys) и rs61751392 (Leu541Pro) ABCA4.

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