scholarly journals The Association of Single Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population

2020 ◽  
Author(s):  
Shaolin Wang ◽  
Wenjuan Zhuang ◽  
Wen Zhang ◽  
Manyun Xu ◽  
Wenjing Li ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Angle Closure ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Biometric Parameters ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Northern Chinese ◽  
Northern Chinese Population

Association between PTCH1 and RAD54B single‐nucleotide polymorphisms and non‐syndromic orofacial clefts in a northern Chinese population

2018 ◽  
Vol 20 (12) ◽  
pp. e3055
Author(s):  
Xiaotong Liu ◽  
Shaoyou Yang ◽  
Lingwei Meng ◽  
Chunyu Chen ◽  
Xiang Hui ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Nucleotide Polymorphisms ◽  
Orofacial Clefts ◽  
Single Nucleotide ◽  
Northern Chinese ◽  
Northern Chinese Population

Single nucleotide polymorphisms of the factor IX gene for linkage analysis in the southern Chinese population

2000 ◽  
Vol 111 (2) ◽  
pp. 540-543 ◽  
Author(s):  
Vivian Chan ◽  
Irene Yam ◽  
B. Yip ◽  
P. Au ◽  
M. K. Shing ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Linkage Analysis ◽  
Chinese Population ◽  
Factor Ix ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Southern Chinese

scholarly journals Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e26953 ◽  
Author(s):  
Ying Wang ◽  
Min Nie ◽  
Wei Li ◽  
Fan Ping ◽  
Yingying Hu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Single Nucleotide Polymorphisms ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Chinese Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Single nucleotide polymorphisms in MLH1 predict poor prognosis of hepatocellular carcinoma in a Chinese population

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 80039-80049 ◽  
Author(s):  
Xiaonian Zhu ◽  
Wei Liu ◽  
Xiaoqiang Qiu ◽  
Zhigang Wang ◽  
Chao Tan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Poor Prognosis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Single Nucleotide Polymorphisms in HOTAIR Are Related to Breast Cancer Risk and Prognosis in the Northeastern Chinese Population

2021 ◽  
Vol 11 ◽  
Author(s):  
Zheng Lv ◽  
Changgui Kou ◽  
Naifei Chen ◽  
Lin Jia ◽  
Xu Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Noncoding Rna ◽  
Disease Free Survival ◽  
Population Based ◽  
Clinicopathological Characteristics ◽  
Nucleotide Polymorphisms ◽  
Binary Logistic Regression Model ◽  
Single Nucleotide

BackgroundThe long noncoding RNA HOX transcript antisense RNA (HOTAIR) is highly expressed in breast cancer (BC) tissues and is associated with the recurrence and metastasis of BC. Until now, the results of studies on associations between several functional single nucleotide polymorphisms(SNPs) (rs920778, rs1899663, and rs4759314) in HOTAIR with BC susceptibility carried out in different regions of China are still inconsistent. There is no study on correlation between HOTAIR SNPs and prognosis of Chinese population. Therefore, we investigated the relationship between HOTAIR SNPs and susceptibility to and prognosis of BC.MethodWe conducted a population-based case-control study involving 828 BC cases and 905 healthy controls. Peripheral blood DNA was used for genotyping. The association between HOTAIR genotypes and BC risk were estimated by odds ratios (ORs) computed using the binary logistic regression model. The relationships between HOTAIR SNPs and clinicopathological features were tested by Pearson’s chi-square test or Fisher’s exact test. Survival was analyzed using the Kaplan-Meier method.ResultsThe functional rs920778 genetic variant increased BC risk in the codominant model. Individuals with the rs920778 GG genotype had an OR of 2.426 (95% confidence interval [CI] = 1.491–3.947, P < 0.001) for developing BC compared to individuals with the AA genotype. Individuals with the AG genotype had an OR of 1.296 (95% CI = 1.040–1.614, P = 0.021) for developing BC compared to individuals with the AA genotype. Individuals with the rs4759314 GA genotype had a lower BC risk than individuals with the rs4759314 AA/GG genotype (OR = 0.566, 95% CI = 0.398–0.803, P = 0.001). The rs1899663 genotype had no correlation with BC susceptibility. Haplotypes composed of rs920778–rs1899663 and rs920778–rs1899663–rs4759314 could increase BC risk (all P < 0.001). There were no statistically significant associations between HOTAIR SNPs and clinicopathological characteristics. The rs920778 GG/AG genotypes were associated with worse disease-free survival (DFS) (p = 0.012), and the rs4759314 GA genotype was associated with worse DFS and overall survival (OS) (p = 0.011).ConclusionHOTAIR SNPs(rs920778 and rs4759314) are significantly related to BC susceptibility and prognosis in the northeastern Chinese population, indicating the significance in the occurrence and development of BC.

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