scholarly journals Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity

2021 ◽  
pp. 306-310
Author(s):  
Ruba Saleh Alghofaili ◽  
Saleh A. Almesfer
Keyword(s):  
In Vitro Fertilization ◽  
Early Diagnosis ◽  
Retinopathy Of Prematurity ◽  
Genetic Disease ◽  
Advanced Stage ◽  
Vitro Fertilization ◽  
Premature Babies ◽  
Bilateral Retinoblastoma

Retinopathy of prematurity (ROP) and retinoblastoma (RB) are well-described entities in premature babies. Although their pathogeneses are different, with ROP representing a disorder of interrupted development and RB a genetic disease, a few co-occurring cases have been reported, raising the possibility that the 2 conditions. Here, we report the sixth such case of co-occurring ROP and RB in an 8-month-old infant conceived by in vitro fertilization (IVF) who developed bilateral retinoblastoma a few months after treatment for advanced-stage ROP. While the ROP was initially adequately managed, bilateral RB necessitated bilateral enucleation. This case raises a number of important questions about whether IVF, ROP, and RB are causally related. Although the associations between IVF, ROP, and RB are likely to be coincidental, this case nevertheless highlights that ROP patients require regular follow-up for early diagnosis and treatment of ocular sequelae including RB.

scholarly journals Effect of the trends of estradiol level on the outcome of in vitro fertilization-embryo transfer with antagonist regimens: a single center retrospective cohort study

2021 ◽  
Author(s):  
Chun-Xiao Wei ◽  
liang zhang ◽  
Cong-Hui Pang ◽  
Ying-Hua qi ◽  
Jian-Wei Zhang
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Pregnancy Outcome ◽  
Embryo Transfer ◽  
Ovarian Response ◽  
Vitro Fertilization ◽  
The Relationship ◽  
Estradiol Levels

Abstract BackgroundThe outcome of in vitro fertilization-embryo transfer is often determined according to follicles and estradiol levels following gonadotropin stimulation. However, there is no accurate indicator to predict pregnancy outcome, and it has not been determined how to choose subsequent drugs and dosage based on the ovarian response. This study aimed to make timely adjustments to follow-up medication to improve clinical outcomes based on the potential value of estradiol growth rate. MethodsSerum estradiol levels were measured on the day of gonadotrophin treatment (Gn0), four days later (Gn4), seven days later (Gn7), and on the trigger day (HCG). The ratio was used to determine the increase in estradiol levels. According to the ratio of estradiol increase, the patients were divided into four groups: group A1 (Gn4/Gn0≤6.44), group A2 (6.44˂Gn4/Gn0≤10.62), group A3 (10.62˂Gn4/Gn0 ≤21.33), and group A4 (Gn4/Gn0>21.33); group B1 (Gn7/Gn4≤2.39), group B2 (2.39˂Gn7/Gn4≤3.03), group B3 (3.03˂Gn7/Gn4≤3.84), and group B4 (Gn7/Gn4>3.84). We analyzed and compared the relationship between data in each group and pregnancy outcome. ResultsIn the statistical analysis, the estradiol levels of Gn4 (P = 0.029, P = 0.042), Gn7 (P< 0.001, P = 0.001), and HCG (P< 0.001, P = 0.002), as well as the ratios of Gn4/Gn0 (P = 0.004, P = 0.006), Gn7/Gn4 (P = 0.001, P = 0.002), and HCG/Gn0 (P< 0.001, P< 0.001) both had clinical guiding significance, and the lower one significantly reduced the pregnancy rate. The outcomes were positively linked to groups A (P = 0.040, P = 0.041) and B (P = 0.015, P = 0.017). The logistical regression analysis revealed that group A1 (OR = 0.440 [0.223–0.865]; P = 0.017, OR = 0.368 [0.169–0.804]; P = 0.012) and B1 (OR = 0.261 [0.126–0.541]; P< 0.001, OR = 0.299 [0.142–0.629]; P = 0.001) had opposite influence on outcomes. ConclusionMaintaining a serum estradiol increase ratio at least above 2.39 on Gn7/Gn4 may result in a higher pregnancy rate. When estradiol growth is not ideal, gonadotrophin dosage should be adjusted appropriately to ensure the desired outcome.

Infertility: Psychological follow-up of children born after in-vitro fertilization

1994 ◽  
Vol 9 (6) ◽  
pp. 1097-1101 ◽  
Author(s):  
A. Raoul-Duval ◽  
M. Bertrand-Servais ◽  
H. Letur-Könirsch ◽  
R. Frydman
Keyword(s):  
In Vitro Fertilization ◽  
Vitro Fertilization

How Important Is Early Diagnosis and Intense Insulin Therapy in In Vitro Fertilization Pregnancies Complicated by Gestational Diabetes Mellitus?

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1436-P
Author(s):  
PETROS THOMAKOS ◽  
OLGA KEPAPTSOGLOU ◽  
ANASTASIA TROUVA ◽  
CAROL BARETTO ◽  
DIMITRIS TROUVAS ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
In Vitro Fertilization ◽  
Early Diagnosis ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Therapy ◽  
Vitro Fertilization

Early diagnosis and treatment of cervical pregnancy in an in vitro fertilization program

1994 ◽  
Vol 61 (5) ◽  
pp. 966-969 ◽  
Author(s):  
Elizabeth S. Ginsburg ◽  
Mary C. Frates ◽  
Mitchell S. Rein ◽  
Janis H. Fox ◽  
Mark D. Hornstein ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Early Diagnosis ◽  
Diagnosis And Treatment ◽  
Fertilization Program ◽  
Vitro Fertilization ◽  
Cervical Pregnancy

Infertility: Five years' follow-up in two patients with borderline tumours of the ovary hyperstimulated by gonadotrophin therapy for in-vitro fertilization

1994 ◽  
Vol 9 (11) ◽  
pp. 2032-2033 ◽  
Author(s):  
Themis Mantzavinos ◽  
Nikos Kanakas ◽  
Costas Genatas ◽  
Kostas Papadias ◽  
Pantelis A. Zourlas
Keyword(s):  
In Vitro Fertilization ◽  
Vitro Fertilization

scholarly journals Psychological Characteristics of Mothers of Children Conceivedwith Use of In Vitro Fertilization

2016 ◽  
Vol 5 (3) ◽  
pp. 69-77
Author(s):  
O.Ju. Kocherova ◽  
L.A. Pykhtina ◽  
H.D. Gadzhimuradova ◽  
O.M. Filkina ◽  
A.I. Malyshkina
Keyword(s):  
In Vitro Fertilization ◽  
Premature Birth ◽  
Psychological Treatment ◽  
Personality Characteristics ◽  
Psychological Characteristics ◽  
Parent Child Relationship ◽  
Vitro Fertilization ◽  
Premature Babies ◽  
Child Relationship

The article is devoted to the study of the psychological characteristics of mothers who gave birth to children conceived using in vitro fertilization. The results of a comparative study of personality characteristics, gestational dominant psychological component, and parent-child relationship 105 mothers of infants conceived via IVF children and 89 mothers who conceived naturally. The methodology used MINI SMIL L.N. Sobchik, test for pregnant I.V. Dobryakova and methods of E.S. Schaeffer, R.K. Bell revealed that mothers of children conceived via IVF, characterized hyperthymic, anxiety and ambition, at least – masculine traits and deliberately. Women often anxiety related to pregnancy and child euphoric attitude towards childbirth. After birth, they are often too much care of their children. Mothers who gave birth to premature babies are more likely than mothers of full-term children, are original and hyperthymic traits. During pregnancy, they often «gipognostichesky type» (little conscious) of relationship to leave, depressive attitude towards yourself and your child, anxious attitude towards strangers. These factors are risk factors for premature birth, therefore, require psychological treatment.

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