scholarly journals Temporal Variation in Staphylococcus aureus Protein A Genotypes from Nose and Skin in Atopic Dermatitis Patients

Dermatology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Minke M.F. van Mierlo ◽  
Suzanne G.M.A. Pasmans ◽  
Joan E.E. Totté ◽  
Jill de Wit ◽  
Bjorn L. Herpers ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Temporal Variation ◽  
Disease Severity ◽  
Severe Disease ◽  
Protein A ◽  
Lesional Skin ◽  
Over Time ◽  
Skin Samples

<b><i>Background:</i></b> <i>Staphylococcus aureus</i> colonization is associated with disease severity in patients with atopic dermatitis (AD). <b><i>Objective:</i></b> To investigate temporal variation in <i>S. aureus</i> protein A gene (<i>spa)</i>-types isolated from the nose and lesional skin and the correlation of <i>spa</i>-types with disease severity. <b><i>Results:</i></b> This study included 96 adult AD patients who were assessed at baseline (T0) and after a strict 2-week follow-up period (T1) in which treatment was standardized with a topical corticosteroid. Fifty-five different <i>spa</i>-types were detected in the nose and skin cultures. Seventy-three patients were colonized with <i>S. aureus</i> in the nasal cavity at both time points (persistent carriership), 59 of whom (81%) had identical <i>spa</i>-types over time. For skin samples, 42 (75%) of the 56 persistent skin carriers had identical <i>spa</i>-types over time. The same <i>spa</i>-type was carried in the nose and skin in 79 and 77% of the patients at T0 and T1, respectively. More severe disease was not associated with specific <i>spa</i>-types or with temporal variation in <i>spa</i>-type. <b><i>Conclusion:</i></b> <i>S. aureus</i> strains in AD are highly heterogeneous between patients. The majority of patients carry the same <i>spa</i>-type in the nose and skin without temporal variation, suggesting clonal colonization within individual patients. No predominant <i>spa</i>-type or temporal variation is associated with increased disease severity.

scholarly journals Variation in Staphylococcus aureus Colonization in Relation to Disease Severity in Adults with Atopic Dermatitis during a Five-month Follow-up

2017 ◽  
Vol 97 (7) ◽  
pp. 802-807 ◽  
Author(s):  
M Alsterholm ◽  
L Strömbeck ◽  
A Ljung ◽  
N Karami ◽  
J Widjestam ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Disease Severity

Temporal variation of Staphylococcus aureus clonal complexes in atopic dermatitis: a follow‐up study

2018 ◽  
Vol 180 (1) ◽  
pp. 181-186 ◽  
Author(s):  
M.‐L. Clausen ◽  
S.M. Edslev ◽  
L.B. Nørreslet ◽  
J.A. Sørensen ◽  
P.S. Andersen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Temporal Variation ◽  
Follow Up Study

Immunoinflammatory Biomarkers in Serum Are Associated with Disease Severity in Atopic Dermatitis

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Jesper Grønlund Holm ◽  
Guillem Hurault ◽  
Tove Agner ◽  
Maja Lisa Clausen ◽  
Sanja Kezic ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Predictive Models ◽  
Severe Disease ◽  
Serum Levels ◽  
Disease Characteristics ◽  
Immunological Markers ◽  
Chemokine Ligand ◽  
Serum Total Ige ◽  
The Relationship

Background: A growing body of evidence links various biomarkers to atopic dermatitis (AD). Still, little is known about the association of specific biomarkers to disease characteristics and severity in AD. Objective: To explore the relationship between various immunological markers in the serum and disease severity in a hospital cohort of AD patients. Methods: Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, were divided into groups based on disease severity (SCORAD). Serum levels of a preselected panel of immunoinflammatory biomarkers were tested for association with disease characteristics. Two machine learning models were developed to predict SCORAD from the measured biomarkers. Results: A total of 160 patients with AD were included; 53 (33.1%) with mild, 73 (45.6%) with moderate, and 34 (21.3%) with severe disease. Mean age was 29.2 years (range 6–70 years) and 84 (52.5%) were females. Numerous biomarkers showed a statistically significant correlation with SCORAD, with the strongest correlations seen for CCL17/thymus and activation-regulated chemokine (chemokine ligand-17/TARC) and CCL27/cutaneous T cell-attracting-chemokine (CTACK; Spearman R of 0.50 and 0.43, respectively, p < 0.001). Extrinsic AD patients were more likely to have higher mean SCORAD (p < 0.001), CCL17 (p < 0.001), CCL26/eotaxin-3 (p < 0.001), and eosinophil count (p < 0.001) than intrinsic AD patients. Predictive models for SCORAD identified CCL17, CCL27, serum total IgE, IL-33, and IL-5 as the most important predictors for SCORAD, but with weaker associations than single cytokines. Conclusions: Specific immunoinflammatory biomarkers in the serum, mainly of the Th2 pathway, are correlated with disease severity in patients with AD. Predictive models identified biomarkers associated with disease severity but this finding warrants further investigation.

scholarly journals Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

2021 ◽  
Vol 11 ◽  
Author(s):  
Patrycja Ogonowska ◽  
Yolanda Gilaberte ◽  
Wioletta Barańska-Rybak ◽  
Joanna Nakonieczna
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Virulence Factors ◽  
Special Interest ◽  
Genetic Background ◽  
Skin Infection ◽  
Healthy Population ◽  
Drug Resistant ◽  
Lesional Skin

Atopic dermatitis (AD) patients are massively colonized with Staphylococcus aureus (S. aureus) in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant S. aureus (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of S. aureus accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of S. aureus in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived S. aureus. Also, we summarize the present and potentially useful future anti-staphylococcal treatment.

scholarly journals Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis

2020 ◽  
Vol 100 (1) ◽  
pp. 1-2
Author(s):  
E Munckhof ◽  
T Kolk ◽  
H Wall ◽  
D Alewijk ◽  
M Doorn ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Adult Patients ◽  
Skin Microbiota ◽  
Lesional Skin ◽  
Over Time

scholarly journals Experience of combined topical therapy with methylprednisoloni aceponatis and «Bepanten Plus»® in treatment of adult patients with moderate and severe atopic dermatitis

2015 ◽  
Vol 12 (6) ◽  
pp. 80-83
Author(s):  
O K Shtyrbul ◽  
O A Erina ◽  
E S Fedenko
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Combined Therapy ◽  
Topical Therapy ◽  
Adult Patients ◽  
Severe Atopic Dermatitis ◽  
Bacterial Isolation ◽  
Treatment Results ◽  
Lesional Skin ◽  
Days Of Therapy

Background. To estimate efficiency of combined therapy with methylprednisolone aceponatis and «Bepanten Plus»® in adult patients with moderate and severe atopic dermatitis. Methods. We examined 32 adult patients, who were treated with TGCS methylprednisolone aceponatis and «Bepanten Plus»®. The efficiency of therapy was estimated with index SCORAD, IGA and subjective patients assessment. For 15 of 32 patients swabs for bacterial isolation to estimate Staphylococcus aureus growth were taken from lesional skin before therapy and on the 14 th or 20 th days of treatment. Results. The аverage value of index SCORAD decreased after 15 days of therapy, Me 41,7 to Me 23,3 a point (p

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