scholarly journals Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature

2021 ◽  
pp. 1733-1740
Author(s):  
Camille Invernizzi ◽  
Victor Gaultier ◽  
Philippe Guilbert ◽  
Christelle Jouannaud ◽  
Anne-Laure Labrousse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Immunosuppressive Treatment ◽  
Pemphigus Vulgaris ◽  
Review Of The Literature ◽  
Systemic Corticosteroids ◽  
End Of Treatment ◽  
Irradiation Field ◽  
Radiation Induced ◽  
Radiotherapy Treatment

Pemphigus is a serious and rare chronic bullous autoimmune disease. It is characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 and 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus is based on the triggering of genetic and external environmental factors such as drugs, infection, and more rarely radiotherapy. To date, only 16 cases of radiation-induced pemphigus are described in the context of breast cancer treatment. We present the case of a 76-year-old woman who had a recurrence of pemphigus vulgaris limited to the irradiation field after exposure to an adjuvant radiotherapy treatment for a bilateral triple-negative breast cancer. The onset was bilateral limited to the irradiation area and was treated effectively with local and systemic corticosteroids. After a rigorous review of the literature, only 16 cases of breast cancer radiation-induced pemphigus appeared. In contrast to several cases, the rash was limited to the irradiated area and improved with systemic corticosteroids. For more than three-quarters of the described cases in the literature, pemphigus occurs within 3 months following the end of treatment. After systemic immunosuppressive treatment, this disease disappears in the vast majority of the reported cases.

Recurrence of pemphigus vulgaris after bilateral breast irradiation: a case report and review of the literature

2021 ◽  
Author(s):  
Camille Invernizzi ◽  
Victor Gaultier ◽  
Philippe Guilbert ◽  
Christelle Jouannaud ◽  
Anne Laure Labrousse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immunosuppressive Treatment ◽  
Pemphigus Vulgaris ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Systemic Corticosteroids ◽  
End Of Treatment ◽  
Rare Side Effect ◽  
Radiation Induced ◽  
Radiotherapy Treatment

Abstract Background Pemphigus is a serious and rare chronic bullous autoimmune disease. It is characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 and 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus is based on the triggering of genetic and external environmental factors such as drugs, infection and more rarely radiotherapy. To date, only 16 cases of radiation-induced pemphigus are described in a context of breast cancer treatment. Case presentation: We present the case of a 76-year-old woman who had a recurrence of pemphigus vulgaris limited to the irradiation field after exposure to an adjuvant radiotherapy treatment for a bilateral triple negative breast cancer. The onset was bilateral limited to the irradiation area and was treated effectively with local and systemic corticosteroids. After a rigorous review of the literature, only 16 cases of breast cancer radiation-induced pemphigus appeared. In contrast to several cases, the rash was limited to the irradiated area and improved with systemic corticosteroids. Conclusions Pemphigus is a very rare side effect of radiotherapy, notably in breast cancer. For more than three-quarters of the described cases in the literature, this condition occurs within three months following the end of treatment. After systemic immunosuppressive treatment, this disease disappears in the vast majority of the reported cases.

scholarly journals Bilateral Breast Edema: Case Report and Review of the Literature

Reports ◽  
2020 ◽  
Vol 3 (3) ◽  
pp. 18
Author(s):  
Andriani D. Vouxinou ◽  
Georgios M. Iatrakis ◽  
Stefanos Zervoudis ◽  
Anastasia Bothou ◽  
Sofia Tsitsiou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Orange Peel ◽  
Breast Ultrasound ◽  
Unknown Etiology ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Total Recovery ◽  
Breast Unit ◽  
End Of Treatment

Both benign and malignant conditions related to regional or systemic disorders could be included in the differential diagnosis of bilateral breast edema. Some of them are often unilateral, including stromal infiltration and lymphatic obstruction presented in “peau d’ orange”, which is the usual presentation of breast cancer. However, the term “idiopathic” could be included in the spectrum of diagnoses. Here, we present a woman of 78 years old who came into our breast unit with a bilateral, painless edema of the breasts (appeared one month ago). Clinical examination revealed that both breasts were swollen with widespread erythema and the appearance of an orange peel/“peau d’ orange”. On palpation, the breasts were not sensitive, and no tumor was palpable. However, clinically palpable lymph nodes were found in both axillas. Her temperature was normal. The breast edema could not be explained from her medical history nor the medications taken. Breast ultrasound, Mammography and Magnetic Resonance Imaging were non-conclusive (BI-RADS 0) and bilateral core biopsy was negative for cancer. Anti-inflammatory plus antibiotic therapy was prescribed for 10 days and at the end of treatment, regional redness and edema were disappeared and reduced, respectively. Total recovery was found one month after the initial findings. It can be concluded that bilateral breast edema is correlated to regional or systemic conditions or it is presented as an “idiopathic” disorder of unknown etiology.

scholarly journals Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation

2017 ◽  
Vol 44 (2) ◽  
pp. 778-791 ◽  
Author(s):  
Man Zou ◽  
Yanhui Li ◽  
Shu Xia ◽  
Qian Chu ◽  
Xiaoguang Xiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Cell Lines ◽  
Triple Negative ◽  
Nuclear Translocation ◽  
Nuclear Accumulation ◽  
Caveolin 1 ◽  
Tnbc Cell ◽  
Radiation Induced ◽  
Her 2

Background/Aims: Triple-negative breast cancer (TNBC) is a high-risk breast cancer phenotype without specific targeted therapy options and is significantly associated with increased local recurrence in patients treated with radiotherapy. CAVEOLIN-1 (CAV-1)-mediated epidermal growth factor receptor (EGFR) nuclear translocation following irradiation promotes DNA repair and thus induces radiation resistance. In this study, we aimed to determine whether knockdown of CAV-1 enhances the radiosensitivity of basal-like TNBC cell lines and to explore the possible mechanisms. Methods: Western blotting was used to compare protein expression in a panel of breast cancer cell lines. Nuclear accumulation of EGFR as well as DNA repair and damage at multiple time points following irradiation with or without CAV-1 siRNA pretreatment were investigated using western blotting and confocal microscopy. The radiosensitizing effect of CAV-1 siRNA was evaluated using a clonogenic assay. Flowcytometry was performed to analyse cell apoptosis and cell cycle alteration. Results: We found that CAV-1 is over-expressed in basal-like TNBC cell lines and barely expressed in HER-2-positive cells; additionally, we observed that HER-2-positive cell lines are more sensitive to irradiation than basal-like TNBC cells. Our findings revealed that radiation-induced EGFR nuclear translocation was impaired by knockdown of CAV-1. In parallel, radiation-induced elevation of DNA repair proteins was also hampered by pretreatment with CAV-1 siRNA before irradiation. Silencing of CAV-1 also promoted DNA damage 24 h after irradiation. Colony formation assays verified that cells could be radiosensitized after knockdown of CAV-1. Furthermore, G2/M cell cycle arrest and apoptosis enhancement may also contribute to the radiosensitizing effect of CAV-1 siRNA. Conclusion: Our results support the hypothesis that CAV-1 knockdown by siRNA causes increased radiosensitivity in basal-like TNBC cells. The mechanisms associated with this effect are reduced DNA repair through delayed CAV-1-associated EGFR nuclear accumulation and induction of G2/M arrest and apoptosis through the combined effects of CAV-1 siRNA and radiation.

scholarly journals The prospects for cisplatin and nab-paclitaxel combination therapy in patients with pre-treated triple-negative breast cancer. Description of the clinical case.

2018 ◽  
pp. 49-55
Author(s):  
L. G. Zhukova ◽  
K. S. Bardovskaya ◽  
E. V. Lubennikova ◽  
I. R. Suslova
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Clinical Case ◽  
Triple Negative ◽  
Review Of The Literature ◽  
Subjective Effect ◽  
Breast Cancer Therapy ◽  
Brca 1 ◽  
Favourable Safety ◽  
Favourable Safety Profile

Molecular and biological features of triple negative breast cancer (TN BC) determine the limited possibilities of systemic therapy and, as a consequence, the more aggressive course of the disease. Taxanes are one of the most effective chemotherapies used in breast cancer therapy. The special form of paclitaxel nab-paclitaxel makes it possible to obtain an objective and a subjective effect, which is especially important in the pre-treated patients. In addition, the drug has a favourable safety profile and a well-controlled toxicity.The article contains a review of the literature on the prospects for the use of nab-paclitaxel in breast cancer, especially in its triple negative version, and a description of the clinical case of therapy with a combination of cisplatin and nab-paclitaxel in a young patient with BRCA-1-associated TN breastcancer.

Capecitabine-induced leukoencephalopathy in a patient with triple-negative breast cancer: A case report and review of the literature

2021 ◽  
pp. 107815522110568
Author(s):  
Li Liu ◽  
Erika N Brown ◽  
Fadi I Abu-Shahin
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Triple Negative Breast Cancer ◽  
Tumor Tissue ◽  
Triple Negative ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Drug Induced ◽  
Naranjo Algorithm ◽  
Metastatic Setting

Introduction Capecitabine is an orally administered prodrug that converts preferentially to 5-fluorouracil within tumors, resulting in enhanced concentrations of 5-fluorouracil in tumor tissue. The use of capecitabine has shown efficacy in the metastatic setting for breast cancer, and more recently, efficacy as adjuvant therapy for triple-negative breast cancer (TNBC). Capecitabine has been shown to be well tolerated with minimal side effects, but the incidence of leukoencephalopathy is rare with a risk of less than one percent. Case report We report on a 34-year-old female patient with left TNBC, moderately differentiated, stage IIB that experienced symptoms of neurotoxicity following initiation of adjuvant chemotherapy with capecitabine. Management and outcome Naranjo Algorithm Assessment score of nine indicated patient had drug-induced leukoencephalopathy leading to discontinuation of capecitabine and resolution of the neurotoxicity symptoms. Discussion Early detection of capecitabine-induced neurotoxicity by magnetic resonance imaging is crucial as symptoms may be reversible to the condition that capecitabine is immediately discontinued.

Radiation-induced sarcomas following radiotherapy for breast cancer: six case reports and a review of the literature

The Breast ◽  
1998 ◽  
Vol 7 (5) ◽  
pp. 277-282 ◽  
Author(s):  
Y.M. Kirova ◽  
F. Feuilhade ◽  
E. Calitchi ◽  
Y. Otmezguine ◽  
J.-P. Le Bourgeois
Keyword(s):  
Breast Cancer ◽  
Case Reports ◽  
Review Of The Literature ◽  
Radiation Induced
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