Platelets and matrix metalloproteinases

2013 ◽  
Vol 110 (11) ◽  
pp. 903-909 ◽  
Author(s):  
Peter Seizer ◽  
Andreas E. May
Keyword(s):  
Endothelial Cells ◽  
Cell Migration ◽  
Matrix Metalloproteinases ◽  
Vascular Injury ◽  
Tumour Cells ◽  
Leukocyte Recruitment ◽  
Receptor Interaction ◽  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteinase ◽  
Tissue Degradation

SummaryMatrix metalloproteinases (MMPs) and their inhibitors essentially contribute to a variety of pathophysiologies by modulating cell migration, tissue degradation and inflammation. Platelet-associated MMP activity appears to play a major role in these processes. First, platelets can concentrate leukocyte-derived MMP activity to sites of vascular injury by leukocyte recruitment. Second, platelets stimulate MMP production in e.g. leukocytes, endothelial cells, or tumour cells by direct receptor interaction or/and by paracrine pathways. Third, platelets synthesise and secrete a variety of MMPs including MMP-1, MMP-2, MMP-3, and MMP-14 (MT1-MMP), and potentially MMP-9 as well as the tissue inhibitors of metalloproteinase (TIMPs). This review focuses on platelet-derived and platelet-induced MMPs and their inhibitors.

scholarly journals Cell Migration in the Immune System: the Evolving Inter-Related Roles of Adhesion Molecules and Proteinases

2000 ◽  
Vol 7 (2-4) ◽  
pp. 103-116 ◽  
Author(s):  
Joseph A. Madri ◽  
Donnasue Graesser
Keyword(s):  
Endothelial Cells ◽  
Cell Migration ◽  
Matrix Metalloproteinases ◽  
Basement Membrane ◽  
Leukocyte Adhesion ◽  
Therapeutic Approaches ◽  
Adhesion Receptors ◽  
Extracellular Matrix Components ◽  
Membrane Bound ◽  
Tissue Site

Leukocyte extravasation into perivascular tissue during inflammation and lymphocyte homing to lymphoid organs involve transient adhesion to the vessel endothelium, followed by transmigration through the endothelial cell (EC) layer and establishment of residency at the tissue site for a period of time. In these processes, leukocytes undergo multiple attachments to, and detachments from, the vessel-lining endothelial cells, prior to transendothelial cell migration. Transmigrating leukocytes must traverse a subendothelial basement membrane en route to perivascular tissues and utilize enzymes known as matrix metalloproteinases to make selective clips in the extracellular matrix components of the basement membrane. This review will focus on the evidence for a link between adhesion of leukocytes to endothelial cells, the induction of matrix metalloproteinases mediated by engagement of adhesion receptors on leukocytes, and the ability to utilize these matrix metalloproteinases to facilitate leukocyte invasion of tissues. Leukocytes with invasive phenotypes express high levels of MMPs, and expression of MMPs enhances the migratory and invasive properties of these cells. Furthermore, MMPs may be used by lymphocytes to proteolytically cleave molecules such as adhesion receptors and membrane bound cytokines, increasing their efficiency in the immune response. Engagement of leukocyte adhesion receptors may modulate adhesive (modulation of integrin affinities and expression), synthetic (proteinase induction and activation), and surface organization (clustering of proteolyric complexes) behaviors of invasive leukocytes. Elucidation of these pathways will lead to better understanding of controlling mechanisms in order to develop rational therapeutic approaches in the areas of inflammation and autoimmunity.

scholarly journals Matrix metalloproteinases and their specific tissue inhibitors in menstruation

Reproduction ◽  
2002 ◽  
pp. 621-631 ◽  
Author(s):  
JC Dong ◽  
H Dong ◽  
A Campana ◽  
P Bischof
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitors ◽  
Proteolytic Activities ◽  
Specific Tissue ◽  
Endometrial Regeneration

The timely breakdown of extracellular matrix is essential for menstruation. Matrix metalloproteinases, which are able to degrade virtually all components of the extracellular matrix, are spatiotemporally expressed in the cyclic endometrium. The expression of most matrix metalloproteinases is regulated transcriptionally and their proteolytic activities are precisely controlled. The balance between matrix metalloproteinases and their specific tissue inhibitors is believed to be crucial for menstruation. This review focuses on the roles of matrix metalloproteinases and their tissue inhibitors in the initiation of menstruation and on the regulation of matrix metalloproteinase expression and activation. For example, the function of matrix metalloproteinases and their tissue inhibitors in endometrial re-epithelialization and angiogenesis during endometrial regeneration, when cell migration is facilitated to ensure endometrial repair, is discussed. This and other processes, although not fully resolved, serve to illustrate the involvement of matrix metalloproteinases and their tissue inhibitors in the process of menstruation.

scholarly journals Decreased Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinase in the Kidneys of Hereditary Nephrotic (ICGN) Mice

2005 ◽  
Vol 67 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Kozue UCHIO-YAMADA ◽  
Noboru MANABE ◽  
Yasufumi GOTO ◽  
Sayuri ANANN ◽  
Yoshie YAMAMOTO ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteinase

scholarly journals Tissue Inhibitors of Metalloproteinase 2 Inhibits Endothelial Cell Migration through Increased Expression of RECK

2004 ◽  
Vol 64 (24) ◽  
pp. 9062-9069 ◽  
Author(s):  
Junseo Oh ◽  
Dong-Wan Seo ◽  
Tere Diaz ◽  
Beiyang Wei ◽  
Yvona Ward ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Endothelial Cell Migration ◽  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteinase
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