scholarly journals NAIL CHANGES IN CASE OF ENTEROVIRAL INFECTIONS IN WESTERN UKRAINE: A REPORT OF 34 CASES

2017 ◽  
Author(s):  
O. R. Boyarchuk ◽  
L. A. Volyanska ◽  
O. M. Dyvonyak
Keyword(s):  
Clinical Features ◽  
Clinical Signs ◽  
Gastrointestinal Symptoms ◽  
Median Number ◽  
Mouth Disease ◽  
Cutaneous Lesions ◽  
Enteroviral Infection ◽  
Nail Changes ◽  
Hand Foot Mouth Disease ◽  
Western Ukraine

Background. Enteroviral infections are common infections, mostly affect children. Nail changes of enteroviral infection including transverse ridging (Beau's lines) and nail shedding (onychomadesis) were described in many countries worldwide.The aim of the research was to investigate the clinical features of the infection that was followed by nail changes during its outbreak in summer-autumn 2016 in Ternopil region, Ukraine.Methods. A case report of 34 children with nail changes that were observed in October 2016 in Ternopil region, Ukraine is presented. All patients were from one kindergarten. Nail trauma, periungual dermatitis, significant medication intake history, systemic diseases were excluded. The survey and clinical examination of cases was performed. Faecal samples were obtained from 13 children with onychomadesis.Results. The median age of the exemined children was 3.97±0.78 years. Interval between onsets of enteroviral infection to nail changes varied from 4 to 12 weeks. Clinical signs that preceded nail changes are fever (64.7%), herpangina (32.6%), pharyngitis (17.6%), gastrointestinal symptoms (44.1%), cutaneous lesions (82.4%) as maculopapular, vesicular rash (44.2%) or/and skin desquamation (41.2%). These clinical data indicate preceded enterovirus infection. In 21 (61.8%) patients hand-foot-mouth disease was suggested.Nail changes were presented by Beau's lines and onychomadesis (nail shedding). The number of affected nails varied from 1 to 16, the median number was 4.88±4.09.Conclusions. Our study proved association between the outbreak of onychomadesis (nail shedding) and enteroviral infection, mainly hand-foot-mouth disease, during summer-autumn 2016 in Western Ukraine (Ternopil region). Enteroviral infection was followed by onychomadesis in 4-12 weeks. Clinical features of enteroviral infection were very variable, with prevalence of cutaneous lesions.More studies are necessary to determine the serotype of the virus that causes onychomadesis.

scholarly journals The Mechanism of Onychomadesis (Nail Shedding) and Beau’s Lines Following Hand-Foot-Mouth Disease

Viruses ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 522 ◽  
Author(s):  
Hsiu-Hui Chiu ◽  
Ming-Tsan Liu ◽  
Wen-Hung Chung ◽  
Yu-Shien Ko ◽  
Chin-Fang Lu ◽  
...  
Keyword(s):  
Late Complications ◽  
Mouth Disease ◽  
Rt Pcr ◽  
Cutaneous Lesions ◽  
Nail Matrix ◽  
Nail Changes ◽  
Hand Foot Mouth Disease ◽  
Atypical Presentations ◽  
Adult Involvement ◽  
A Minor

Background: Nail changes, including onychomadesis (nail shedding) and Beau’s line, following hand-foot-mouth disease (HFMD) are a common emergence at the stage of late complications of HFMD. However, the exact mechanism is still unknown. Therefore, we conducted this study to elucidate the mechanism of nail changes following HFMD. Methods: We collected 11 patients suffering from onychomadesis following HFMD. Nail samples from all of them were collected. Real time reverse transcription polymerase chain reaction (RT-PCR) and sequencing for human enteroviruses (HEV) were performed. Throat swabs for RT-PCR and sequencing for HEV were performed for three cases. Results: RT-PCR demonstrated the presence of Coxackievirus A6 (CVA6) in nail samples from three patients and one with Echovirus. Conclusion: In conclusion, we believe that the major cause of onychomadesis following HFMD is that certain novel viruses, mostly CVA6, are virulent and may damage nail matrix. Direct injury caused by cutaneous lesions of HFMD around nail matrix is a minor cause. There are still other virulent HEV which may result in onychomadesis. In addition, the novel strain of CVA6 also causes atypical clinical presentations, such as adult involvement and delayed-onset palmar and plantar desquamation. Physicians should be familiar with atypical presentations caused by novel viruses to avoid misdiagnosis and even inform patients of the possibility of onychomadesis that may take place weeks later to reassure patients.

scholarly journals Clinical features and virology of hand foot mouth disease in Southern Vietnam, July 2013 - March 2015

2016 ◽  
Vol 45 ◽  
pp. 20 ◽  
Author(s):  
V.M.T. Hoang ◽  
T.A. Nguyen ◽  
T.T. Tran ◽  
M.T. Ha ◽  
V. Do ◽  
...  
Keyword(s):  
Clinical Features ◽  
Mouth Disease ◽  
Southern Vietnam ◽  
Hand Foot Mouth Disease

scholarly journals Onychomadesis Developed Only on the Nails Having Cutaneous Lesions of Severe Hand-Foot-Mouth Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
Emi Shikuma ◽  
Yuichiro Endo ◽  
Akihiro Fujisawa ◽  
Miki Tanioka ◽  
Yoshiki Miyachi
Keyword(s):  
Mouth Disease ◽  
Cutaneous Lesions ◽  
Hand Foot Mouth Disease

This paper reported a case of onychomadesis which appeared on the nails after heal of cutaneous lesions of hand-foot-mouth disease (HFMD). There were a few reports describing onychomadesis after HFMD; however, the mechanism is still unclear. The present case was prospectively observed, and onychomadesis was found to develop only on the nails having cutaneous lesions of HFMD. We considered that nail dysfunction due to direct inflammation spreading from skin eruptions around nail is one of the causes of onychomadesis linked toHFMD.

scholarly journals Google Technology in the Surveillance of Hand Foot Mouth Disease in Asia

2014 ◽  
Vol 1 ◽  
pp. 27-35 ◽  
Author(s):  
Rachael Cayce ◽  
Kathleen Hesterman ◽  
Paul Bergstresser
Keyword(s):  
Mathematical Model ◽  
Developed Countries ◽  
Mouth Disease ◽  
Surveillance Data ◽  
Strongly Correlated ◽  
Web Based ◽  
Search Queries ◽  
Enteroviral Infection ◽  
Hand Foot Mouth Disease ◽  
Potential Resource

Background: Hand foot Mouth Disease (HFMD) is a worldwide Enteroviral infection; severe outbreaks have occurred recently in the US and Asia. Google technology has been shown to predict influenza epidemics and is a potential resource to track epidemics in developed countries where the use of Web-based searches is prevalent.Methods: Google Trends and Google Correlate were used to enumerate Web based search queries related to HFMD in three Asian regions and were compared to known seasonal variations and standard surveillance data to investigate for strong correlation. We also test whether a mathematical model, constructed using Google Correlate, would have been able to predict, in retrospect, an outbreak of HFMD in Singapore.Results:  HFMD-related search queries strongly correlated to known HFMD seasonal variation and standard surveillance data. Our mathematical model of Singaporean HFMD did predict the magnitude and chronology of the summer 2012 outbreak.Conclusions: Given the correlation of Google technology with known HFMD seasonal patterns and surveillance data in select Asian regions, this technology shows enormous potential for HFMD surveillance. Further prospective studies are needed to validate the utility of Google technology in HFMD surveillance.

scholarly journals Nail changes secondary to hand-foot-mouth disease

2016 ◽  
Vol 58 (3) ◽  
pp. 287 ◽  
Author(s):  
Nebahat Demet Akpolat ◽  
Nezih Karaca
Keyword(s):  
Mouth Disease ◽  
Nail Changes ◽  
Hand Foot Mouth Disease

scholarly journals Nail Changes following Hand-Foot-Mouth Disease in North India

2021 ◽  
Vol 7 (4) ◽  
Author(s):  
Ramesh Choudhary ◽  
Vivek Athwani ◽  
Sunil Gothwal
Keyword(s):  
Mouth Disease ◽  
North India ◽  
Outpatient Clinics ◽  
Common Disease ◽  
Preventive Strategies ◽  
Nail Changes ◽  
Male Preponderance ◽  
Hand Foot Mouth Disease

: Hand-foot-mouth disease (HFMD) is common, but nail changes have not been well described. We described nail changes in HFMD. Nail changes following (HFMD) in two outpatient clinics were assessed over two years. Out of 524 cases of HFMD, 40 patients (7.6%) presented with nail problems, 29 cases had onychomadesis, and 11 cases had Beau’s lines. The median age of the subjects was 36 (15 - 126) months, and slight male preponderance (23:17) was seen. HFMD is a common disease having delayed nail changes also. So identification of and preventive strategies are required to limit complications.

Gianotti-Crosti syndrome and atypical hand-foot-mouth disease: two distinct entities or two manifestation of the same infection?

2020 ◽  
Vol 155 (1) ◽  
Author(s):  
Elisabetta Venturini ◽  
Luisa Galli ◽  
Elena Chiappini ◽  
Maurizio De Martino ◽  
Andrea Bassi
Keyword(s):  
Mouth Disease ◽  
Hand Foot Mouth Disease

scholarly journals Pediatric COVID-19 and the Factors That May Mitigate Its Clinical Course

2020 ◽  
Vol 10 (01) ◽  
pp. e137-e140
Author(s):  
Mosaad Abdel-Aziz ◽  
Nada M. Abdel-Aziz ◽  
Dina M. Abdel-Aziz ◽  
Noha Azab
Keyword(s):  
Clinical Features ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Angiotensin Converting Enzyme 2 ◽  
Compulsory Vaccination ◽  
Specific Factors ◽  
Novel Coronavirus ◽  
Radiographic Data

AbstractThe clinical manifestations of novel coronavirus disease 2019 (COVID-19) vary from mild flu-like symptoms to severe fatal pneumonia. However, children with COVID-19 may be asymptomatic or may have mild clinical symptoms. The aim of this study was to investigate clinical features of pediatric COVID-19 and to search for the factors that may mitigate the disease course. We reviewed the literature to realize the clinical features, laboratory, and radiographic data that may be diagnostic for COVID-19 among children. Also, we studied the factors that may affect the clinical course of the disease. Fever, dry cough, and fatigue are the main symptoms of pediatric COVID-19, sometimes flu-like symptoms and/or gastrointestinal symptoms may be present. Although some infected children may be asymptomatic, a recent unusual hyperinflammatory reaction with overlapping features of Kawasaki's disease and toxic shock syndrome in pediatric COVID-19 has been occasionally reported. Severe acute respiratory syndrome-coronvirus-2 (SARS-CoV-2) nucleic acid testing is the corner-stone method for the diagnosis of COVID-19. Lymphocyte count and other inflammatory markers are not essentially diagnostic; however, chest computed tomography is highly specific. Factors that may mitigate the severity of pediatric COVID-19 are home confinement with limited children activity, trained immunity caused by compulsory vaccination, the response of the angiotensin-converting enzyme 2 receptors in children is not the same as in adults, and that children are less likely to have comorbidities. As infected children may be asymptomatic or may have only mild respiratory and/or gastrointestinal symptoms that might be missed, all children for families who have a member diagnosed with COVID-19 should be investigated.

Sign in / Sign up

Export Citation Format

Share Document