scholarly journals The Mechanism of Onychomadesis (Nail Shedding) and Beau’s Lines Following Hand-Foot-Mouth Disease

Viruses ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 522 ◽  
Author(s):  
Hsiu-Hui Chiu ◽  
Ming-Tsan Liu ◽  
Wen-Hung Chung ◽  
Yu-Shien Ko ◽  
Chin-Fang Lu ◽  
...  
Keyword(s):  
Late Complications ◽  
Mouth Disease ◽  
Rt Pcr ◽  
Cutaneous Lesions ◽  
Nail Matrix ◽  
Nail Changes ◽  
Hand Foot Mouth Disease ◽  
Atypical Presentations ◽  
Adult Involvement ◽  
A Minor

Background: Nail changes, including onychomadesis (nail shedding) and Beau’s line, following hand-foot-mouth disease (HFMD) are a common emergence at the stage of late complications of HFMD. However, the exact mechanism is still unknown. Therefore, we conducted this study to elucidate the mechanism of nail changes following HFMD. Methods: We collected 11 patients suffering from onychomadesis following HFMD. Nail samples from all of them were collected. Real time reverse transcription polymerase chain reaction (RT-PCR) and sequencing for human enteroviruses (HEV) were performed. Throat swabs for RT-PCR and sequencing for HEV were performed for three cases. Results: RT-PCR demonstrated the presence of Coxackievirus A6 (CVA6) in nail samples from three patients and one with Echovirus. Conclusion: In conclusion, we believe that the major cause of onychomadesis following HFMD is that certain novel viruses, mostly CVA6, are virulent and may damage nail matrix. Direct injury caused by cutaneous lesions of HFMD around nail matrix is a minor cause. There are still other virulent HEV which may result in onychomadesis. In addition, the novel strain of CVA6 also causes atypical clinical presentations, such as adult involvement and delayed-onset palmar and plantar desquamation. Physicians should be familiar with atypical presentations caused by novel viruses to avoid misdiagnosis and even inform patients of the possibility of onychomadesis that may take place weeks later to reassure patients.

scholarly journals NAIL CHANGES IN CASE OF ENTEROVIRAL INFECTIONS IN WESTERN UKRAINE: A REPORT OF 34 CASES

2017 ◽  
Author(s):  
O. R. Boyarchuk ◽  
L. A. Volyanska ◽  
O. M. Dyvonyak
Keyword(s):  
Clinical Features ◽  
Clinical Signs ◽  
Gastrointestinal Symptoms ◽  
Median Number ◽  
Mouth Disease ◽  
Cutaneous Lesions ◽  
Enteroviral Infection ◽  
Nail Changes ◽  
Hand Foot Mouth Disease ◽  
Western Ukraine

Background. Enteroviral infections are common infections, mostly affect children. Nail changes of enteroviral infection including transverse ridging (Beau's lines) and nail shedding (onychomadesis) were described in many countries worldwide.The aim of the research was to investigate the clinical features of the infection that was followed by nail changes during its outbreak in summer-autumn 2016 in Ternopil region, Ukraine.Methods. A case report of 34 children with nail changes that were observed in October 2016 in Ternopil region, Ukraine is presented. All patients were from one kindergarten. Nail trauma, periungual dermatitis, significant medication intake history, systemic diseases were excluded. The survey and clinical examination of cases was performed. Faecal samples were obtained from 13 children with onychomadesis.Results. The median age of the exemined children was 3.97±0.78 years. Interval between onsets of enteroviral infection to nail changes varied from 4 to 12 weeks. Clinical signs that preceded nail changes are fever (64.7%), herpangina (32.6%), pharyngitis (17.6%), gastrointestinal symptoms (44.1%), cutaneous lesions (82.4%) as maculopapular, vesicular rash (44.2%) or/and skin desquamation (41.2%). These clinical data indicate preceded enterovirus infection. In 21 (61.8%) patients hand-foot-mouth disease was suggested.Nail changes were presented by Beau's lines and onychomadesis (nail shedding). The number of affected nails varied from 1 to 16, the median number was 4.88±4.09.Conclusions. Our study proved association between the outbreak of onychomadesis (nail shedding) and enteroviral infection, mainly hand-foot-mouth disease, during summer-autumn 2016 in Western Ukraine (Ternopil region). Enteroviral infection was followed by onychomadesis in 4-12 weeks. Clinical features of enteroviral infection were very variable, with prevalence of cutaneous lesions.More studies are necessary to determine the serotype of the virus that causes onychomadesis.

scholarly journals Onychomadesis Developed Only on the Nails Having Cutaneous Lesions of Severe Hand-Foot-Mouth Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
Emi Shikuma ◽  
Yuichiro Endo ◽  
Akihiro Fujisawa ◽  
Miki Tanioka ◽  
Yoshiki Miyachi
Keyword(s):  
Mouth Disease ◽  
Cutaneous Lesions ◽  
Hand Foot Mouth Disease

This paper reported a case of onychomadesis which appeared on the nails after heal of cutaneous lesions of hand-foot-mouth disease (HFMD). There were a few reports describing onychomadesis after HFMD; however, the mechanism is still unclear. The present case was prospectively observed, and onychomadesis was found to develop only on the nails having cutaneous lesions of HFMD. We considered that nail dysfunction due to direct inflammation spreading from skin eruptions around nail is one of the causes of onychomadesis linked toHFMD.

scholarly journals Nail changes secondary to hand-foot-mouth disease

2016 ◽  
Vol 58 (3) ◽  
pp. 287 ◽  
Author(s):  
Nebahat Demet Akpolat ◽  
Nezih Karaca
Keyword(s):  
Mouth Disease ◽  
Nail Changes ◽  
Hand Foot Mouth Disease

scholarly journals Nail Changes following Hand-Foot-Mouth Disease in North India

2021 ◽  
Vol 7 (4) ◽  
Author(s):  
Ramesh Choudhary ◽  
Vivek Athwani ◽  
Sunil Gothwal
Keyword(s):  
Mouth Disease ◽  
North India ◽  
Outpatient Clinics ◽  
Common Disease ◽  
Preventive Strategies ◽  
Nail Changes ◽  
Male Preponderance ◽  
Hand Foot Mouth Disease

: Hand-foot-mouth disease (HFMD) is common, but nail changes have not been well described. We described nail changes in HFMD. Nail changes following (HFMD) in two outpatient clinics were assessed over two years. Out of 524 cases of HFMD, 40 patients (7.6%) presented with nail problems, 29 cases had onychomadesis, and 11 cases had Beau’s lines. The median age of the subjects was 36 (15 - 126) months, and slight male preponderance (23:17) was seen. HFMD is a common disease having delayed nail changes also. So identification of and preventive strategies are required to limit complications.

Cloning of the cDNA Encoding Human Platelet CD36: Comparison to PCR Amplified Fragments of Monocyte, Endothelial and HEL Cells

1993 ◽  
Vol 70 (03) ◽  
pp. 500-505 ◽  
Author(s):  
B Wyler ◽  
L Daviet ◽  
H Bortkiewicz ◽  
J-C Bordet ◽  
J L McGregor
Keyword(s):  
Apparent Molecular Weight ◽  
Platelet Glycoprotein ◽  
Rt Pcr ◽  
Post Translational Modifications ◽  
Hel Cells ◽  
Flanking Region ◽  
Polymerase Chain ◽  
A Minor ◽  
Flanking Regions ◽  
Cdna Fragments

SummaryGlycoprotein CD36, also known as GPIIIb or GPIV, is a major platelet glycoprotein that bears the newly identified Naka alloantigen. The aim of this study was to clone platelet CD36 and investigate other forms of CD36-cDNA present in monocytes, endothelial and HEL cells. RNA from above mentioned cells were reverse transcribed (RT), using specific primers for CD36, and amplified by the polymerase chain reaction (PCR) technique. Sequencing the different amplified platelet derived cDNA fragments, spanning the whole coding and flanking regions, showed the near identity between platelet and CD36-placenta cDNA. Platelet CD36-cDNA cross-hybridized, in Southern blots, with RT-PCR amplified cDNA originating from monocytes, endothelial and HEL cells. However, monocytes showed a RT-PCR amplified cDNA fragment (561 bp) that was present in platelets and placenta but not on endothelial on HEL-cells. Northern blot analysis of platelet RNA hybridized with placenta CD36 indicated the presence of a major (1.95 kb) and a minor (0.95 kb) transcript. The 1.95 kb transcript was the only one observed on Northern blots of monocytes, endothelial and HEL cells. These results indicate that the structure of CD36 expressed in platelets is similar, with the exception of the 3’ flanking region, to that of placenta. Differences in apparent molecular weight between CD36 and CD36-like glycoproteins may be due to post-translational modifications.

Gianotti-Crosti syndrome and atypical hand-foot-mouth disease: two distinct entities or two manifestation of the same infection?

2020 ◽  
Vol 155 (1) ◽  
Author(s):  
Elisabetta Venturini ◽  
Luisa Galli ◽  
Elena Chiappini ◽  
Maurizio De Martino ◽  
Andrea Bassi
Keyword(s):  
Mouth Disease ◽  
Hand Foot Mouth Disease
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