scholarly journals Effects of TiO>sub/sub< nanoparticles addition on dense bovine hydroxyapatite bioceramic on human odontoblasts

2021 ◽  
Author(s):  
Paulo Henrique Martins Fernandes
Keyword(s):  
Bovine Hydroxyapatite

scholarly journals Role of collagen membrane in lateral onlay grafting with bovine hydroxyapatite incorporated with collagen matrix in dogs

2013 ◽  
Vol 43 (2) ◽  
pp. 64 ◽  
Author(s):  
Ui-Won Jung ◽  
Jung-Seok Lee ◽  
Geun Lee ◽  
In-Kyeong Lee ◽  
Ji-Wan Hwang ◽  
...  
Keyword(s):  
Collagen Matrix ◽  
Collagen Membrane ◽  
Bovine Hydroxyapatite

Fabrication and characterization of bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked by glutaraldehyde for bone regeneration

2021 ◽  
Vol 32 (4) ◽  
pp. 555-560
Author(s):  
Samirah ◽  
Aniek Setiya Budiatin ◽  
Ferdiansyah Mahyudin ◽  
Junaidi Khotib
Keyword(s):  
Compressive Strength ◽  
Bone Regeneration ◽  
Mtt Assay ◽  
Local Treatment ◽  
Swelling Ratio ◽  
High Concentration ◽  
Proliferation And Differentiation ◽  
Bovine Hydroxyapatite

Abstract Objectives Alendronate are widely used in the treatment of bone disorders characterized by inhibit osteoclast-mediated bone resorption such as Paget’s disease, fibrous dysplasia, myeloma, bone metastases and osteoporosis. In recent studies alendronate improves proliferation and differentiation of osteoblasts, thereby facilitating for bone regeneration. The disadvantages of this class are their poor bioavailability and side effects on oral and intravenous application such as stomach irritation and osteonecrosis in jaw. Thus, local treatment of alendronate is needed in order to achieve high concentration of drug. Bovine hydroxyapatite-gelatin scaffold with alendronate was studied. Glutaraldehyde was used as cross-linking agent, increase the characteristics of this scaffold. The objectives of this study were to manufacture and characterize alendronate scaffold using bovine hydroxyapatite-gelatin and crosslinked by glutaraldehyde. Methods Preparation of cross-linked bovine hydroxyapatite-gelatin and alendronate scaffold with different concentration of glutaraldehyde (0.00, 0.50, 0.75, and 1.00%). The scaffolds were characterized for compressive strength, porosity, density, swelling ratio, in vitro degradation, and cytotoxicity (the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, shorted as MTT assay). Results Bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked with glutaraldehyde showed lower density than without glutaraldehyde. As glutaraldehyde concentration increased, porosity also increased. Eventually, it reduced compressive strength. Swelling ratio and in vitro degradation was negatively dependent on glutaraldehyde concentration. In addition, the scaffold has a good safety by MTT assay. Conclusions Bovine hydroxyapatite-gelatin-alendronate scaffold was fabricated with various concentrations of glutaraldehyde. The presence of glutaraldehyde on bovine hydroxyapatite-gelatin-alendronate is safe and suitable candidate scaffold for bone regeneration.

Improvement of Microstructure of Bovine Hydroxyapatite (BHA) by Doping with Calcium Fluoride

2007 ◽  
pp. 43-46
Author(s):  
L.S. Ozyegin ◽  
Faik N. Oktar ◽  
Simeon Agathopoulos ◽  
S. Salman ◽  
Y. Bozkurt ◽  
...  
Keyword(s):  
Calcium Fluoride ◽  
Bovine Hydroxyapatite

Improvement of Microstructure of Bovine Hydroxyapatite (BHA) with Machineable Fluorapatite Glass (MFG)

2007 ◽  
pp. 495-498
Author(s):  
Oguzhan Gunduz ◽  
S. Salman ◽  
S. Kayali ◽  
Gultekin Goller ◽  
I. Goker ◽  
...  
Keyword(s):  
Bovine Hydroxyapatite

Sintering Effect on Boron Based Bioglass Doped Composites of Bovine Hydroxyapatite

2012 ◽  
Vol 445 ◽  
pp. 982-987
Author(s):  
Oguzhan Gunduz ◽  
Zeeshan Ahmad ◽  
S. Salman ◽  
A.T. Inan ◽  
Nazmi Ekren ◽  
...  
Keyword(s):  
Bovine Hydroxyapatite ◽  
Sintering Effect

scholarly journals Effect of Sintering on In Vivo Biological Performance of Chemically Deproteinized Bovine Hydroxyapatite

Materials ◽  
2019 ◽  
Vol 12 (23) ◽  
pp. 3946 ◽  
Author(s):  
Bruno De Carvalho ◽  
Eric Rompen ◽  
Geoffrey Lecloux ◽  
Peter Schupbach ◽  
Emilie Dory ◽  
...  
Keyword(s):  
Surface Area ◽  
Alveolar Bone ◽  
Structural Characteristics ◽  
Morphological Properties ◽  
Critical Conditions ◽  
Lower Percentage ◽  
Material Contact ◽  
Bovine Hydroxyapatite ◽  
Biological Performance

The influence of the manufacturing process on physicochemical properties and biological performance of xenogenic biomaterials has been extensively studied, but its quantification on bone-to-material contact remains poorly investigated. The aim of this study was to investigate the effect of different heat treatments of an experimental chemically-deproteinized bovine hydroxyapatite in vivo in terms of new bone formation and osteoconductivity. Protein-free hydroxyapatite from bovine origin was produced under sub-critical conditions and then either sintered at 820 °C or 1200 °C. Structural and morphological properties were assessed by scanning electron microscopy (SEM), measurement of surface area and X-ray diffractometry (XRD). The materials were then implanted in standardized alveolar bone defects in minipigs and histomorphometric evaluations were performed using non-decalcified sections. Marked topographical differences were observed by SEM analysis. As the sintering temperature of the experimental material increased, the surface area significantly decreased while crystallite size increased. In vivo samples showed that the highly sintered BHA presented a significantly lower percentage of newly formed bone than the unheated one (p = 0.009). In addition, the percentage of bone-to-material contact (BMC) was significantly lowered in the highly sintered group when compared to the unsintered (p = 0.01) and 820 °C sintered (p = 0.02) groups. Non-sintered or sintered at 820 °C BHA seems to maintain a certain surface roughness allowing better bone regeneration and BMC. On the contrary, sintering of BHA at 1200 °C has an effect on its morphological and structural characteristics and significantly modify its biological performance (osteoconductivity) and crystallinity.

scholarly journals Periodontal regenerative effect of a bovine hydroxyapatite/collagen block in one-wall intrabony defects in dogs: a histometric analysis

2011 ◽  
Vol 41 (6) ◽  
pp. 285 ◽  
Author(s):  
Ui-Won Jung ◽  
Jung-Seok Lee ◽  
Weon-Yeong Park ◽  
Jae-Kook Cha ◽  
Ji-Wan Hwang ◽  
...  
Keyword(s):  
Intrabony Defects ◽  
Regenerative Effect ◽  
Bovine Hydroxyapatite

scholarly journals Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Gustavo Grossi-Oliveira ◽  
Leonardo P. Faverani ◽  
Bruno Coelho Mendes ◽  
Tárik Ocon Braga Polo ◽  
Gabriel Cury Batista Mendes ◽  
...  
Keyword(s):  
Bone Repair ◽  
Immunohistochemical Analysis ◽  
Bone Substitutes ◽  
Vascular Endothelial ◽  
Calvarial Bone ◽  
Critical Size Defects ◽  
Related Transcription Factor ◽  
Osteoconductive Property ◽  
Bovine Hydroxyapatite ◽  
Endothelial Growth Factor

This study evaluated the osteoconductive potential of four biomaterials used to fill bone defects. For this, 24 male Albino rabbits were submitted to the creation of a bilateral 8 mm calvarial bone defect. The animals were divided into four groups—bovine hydroxyapatite, Bio-Oss® (BIO); Lumina-Bone Porous® (LBP); Bonefill® (BFL); and an alloplastic material, Clonos® (CLN)—and were euthanized at 14 and 40 days. The samples were subjected to histological and histometric analysis for newly formed bone area. Immunohistochemical analysis for Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF), and osteocalcin (OC) was performed. After statistical analysis, the CLN group showed greater new bone formation (NB) in both periods analyzed (p<0.05). At 14 days, the NB showed greater values in BIO in relation to LBP and BFL groups; however, after 40 days, the LBP group surpassed the results of BIO (p<0.001). The immunostaining showed a decrease in Runx2 intensity in BIO after 40 days, while it increased for LBP (p<0.05). The CLN showed increased OC compared to the other groups in both periods analyzed (p<0.05). Therefore, CLN showed the best osteoconductive behavior in critical defects in rabbit calvaria, and BFL showed the lowest osteoconductive property.

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