scholarly journals Multitherapeutic nanoplatform based on Scintillating Anthracene, Silver@Antracene, and Gold@Anthracene nanoparticles for combined radiation and photodynamic therapies: enhancing radiation dose while generating, trapping, probing, or delivering singlet oxygen species

2021 ◽  
Author(s):  
Jeferson da Silva Oliveira
Keyword(s):  
Radiation Dose ◽  
Singlet Oxygen ◽  
Oxygen Species ◽  
Singlet Oxygen Species

Synthesis of pH-Responsive Glycopolymer with End Group Zinc(II) Phthalocyanines as Potential Photosensitizer

2020 ◽  
Vol 996 ◽  
pp. 82-87
Author(s):  
Shu Guo Dong ◽  
Gui Hua Cui ◽  
Qian Duan
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Raft Polymerization ◽  
Photophysical Properties ◽  
Water Soluble ◽  
Quantum Yields ◽  
Oxygen Species ◽  
Ph Responsive ◽  
Reversible Addition ◽  
Singlet Oxygen Species

A novel end-functionalized glycopolymer poly (3-O-methacryloyl-D-glucofuranose) -b-poly (2-Diethylaminoethyl Methacrylate) (PMAGlc-b-PDEA-ZnTAPc) with zinc (II) teraamaninophthalocyanine was synthesized. First, a pH-responsive copolymer PMAIpG-b-PDEA was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Then PMAIpG-b-PDEA reacted with ZnTAPc and deprotected to form a water-soluble and pH-responsive photosensitizer. The structure of the PMAGlc-b-PDEA-ZnTAPc was characterized by 1H NMR and GPC. The photophysical properties were evaluated by UV-Vis and fluorescence spectra. The PMAGlc-b-PDEA-ZnTAPc can generate singlet oxygen species with good singlet oxygen quantum yields (Φ△=0.38), which is believed to be the major cytotoxic reactive oxygen species (ROS) for photodynamic therapy. The ZnPc functionalized glycopolymer will be used as a potential photosensitizer in the fields of photodynamic therapy.

First Evidence of Singlet Oxygen Species Mechanism in Silicate Clay for Antimicrobial Behavior

2013 ◽  
Vol 1569 ◽  
pp. 67-72
Author(s):  
Jiun-Chiou Wei ◽  
Yi-Ting Wang ◽  
Jiang-Jen Lin
Keyword(s):  
Singlet Oxygen ◽  
Methicillin Resistance ◽  
Antimicrobial Property ◽  
Multilayered Structure ◽  
Chemical Mechanism ◽  
Oxygen Species ◽  
Property A ◽  
E Coli ◽  
Resistant Species ◽  
Singlet Oxygen Species

ABSTRACTThin silicate nanoplatelets, derived from the exfoliation of natural Sodium montmorillonite (Na+-MMT) clays, show an unexpected antimicrobial property. A physical trapping mechanism has been proposed because the clay nanoplatelets can indiscriminately inhibit the growth of a broad spectrum of bacteria, including drug-resistant species such as methicillin-resistance S. aureus (MRSA) and silver ion-resistant E. coli. The ability to generate singlet oxygen species was first observed for the clay platelets that showed a high-aspect-ratio geometric shape and the presence of surface ionic charges. By comparison, the pristine clay with a multilayered structure failed to generate any singlet oxygen species. The ability to emit singlet oxygen species provides direct evidence for the antimicrobial ability of clay through a non-chemical mechanism, which opens the potential for medical use.

Selective photooxidation of sulfides mediated by singlet oxygen using visible-light-responsive coordination polymers

2018 ◽  
Vol 54 (92) ◽  
pp. 13002-13005 ◽  
Author(s):  
Xiao Liang ◽  
Zhifen Guo ◽  
Hongxia Wei ◽  
Xin Liu ◽  
Hui Lv ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
Visible Light ◽  
Singlet Oxygen ◽  
Coordination Polymers ◽  
Oxygen Species ◽  
Singlet Oxygen Species

A novel visible-light-responsive coordination polymer for highly selective photooxidation of sulfides to produce sulfoxides through singlet oxygen species.

scholarly journals Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

2021 ◽  
Vol 9 ◽  
Author(s):  
Keshavananda Prabhu C. P. ◽  
Manjunatha Nemakal ◽  
Muthumuni Managa ◽  
Tebello Nyokong ◽  
Lokesh Koodlur Sannegowda
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Clinical Response ◽  
Macrocyclic Complexes ◽  
Oxygen Species ◽  
Early Biomarker ◽  
Singlet Oxygen Species ◽  
Mcf 7

N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.

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