Oral soft-tissue sarcomas diagnosed in an oral pathology service: a 16year experience

Objective: This study analyzed the prevalence and clinic-pathological features of soft-tissue sarcomas diagnosed in a single-center of oral pathology from a School of Dentistry in Brazil. Materials and methods: All consecutive cases of intra-oral soft-tissue sarcomas diagnosed between January of 2002 and December of 2018 were retrieved from the files; patient data (sex, age and race) and characteristics of the lesions (site, size, clinical aspect and duration of injury) were collected. Results: Among a total of 62,255 biopsies diagnosed in the studied period, soft-tissue oral sarcomas comprised 76 cases (0.12%). Kaposi sarcoma, rhabdomyosarcoma, leiomyosarcoma encompassed 64.5% of the cases, and 53% of these were diagnosed as Kaposi Sarcoma. Male patients were more affected (59.2%) and white patients comprised 50%. In general, 39.4% of the patients were between 21-40yo. Conclusion: Soft-tissue sarcomas are rare in oral soft-tissue and in our pathology service, they comprised only 0.12% of all diseases diagnosed in the studied period. Kaposi sarcoma was the most frequent, followed by leiomyosarcoma and rhabdomyosarcoma. Thus, it is important for stomatologists and pathologists to be aware of their characteristics when examining oral mucosa, mainly their peculiarities regarding patient’s age, clinical appearance, and site of occurrence.

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Elevated frequency of a specific allele of the l-MYC gene in male patients with bone and soft-tissue sarcomas

International Journal of Cancer ◽

10.1002/ijc.2910450110 ◽

1990 ◽

Vol 45 (1) ◽

pp. 47-49 ◽

Cited By ~ 28

Author(s):

Mitsuo Kato ◽

Junya Toguchida ◽

Kazuo Honda ◽

Masao S. Sasaki ◽

Mituo Ikenaga ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcomas ◽

Specific Allele ◽

Myc Gene ◽

Male Patients ◽

Elevated Frequency

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Sarcomas of Soft Tissue and Bone

10.2310/im.1187 ◽

2011 ◽

Author(s):

Adam Lerner ◽

Huihong Xu ◽

Karen H Antman

Keyword(s):

Soft Tissue ◽

Meta Analysis ◽

Survival Rates ◽

Fibrous Tissue ◽

Soft Tissue Sarcomas ◽

Kaposi Sarcoma ◽

Uterine Leiomyosarcoma ◽

Increased Risk ◽

Bone Sarcomas ◽

Epidemiologic Features

Sarcomas originate from bone or soft tissue. The most common bone sarcomas are osteosarcomas, Ewing sarcomas, and chondrosarcomas. Soft tissue sarcomas develop in fibrous tissue, fat, muscle, blood vessels, and nerves. Historically, soft tissue sarcomas of the trunk and extremities were reported separately from those of visceral organs (e.g., gastrointestinal and gynecologic sarcomas). This chapter discusses the classification, epidemiology, diagnosis, staging, and treatment of sarcomas of bone and cartilage, and classic soft tissue sarcomas. Management of Kaposi sarcoma, gastrointestinal stromal tumors (GISTs), mesothelioma, and rhabdomyosarcoma is also described. Figures include images of patients with osteosarcoma, liposarcoma, uterine leiomyosarcoma, GIST, and osteosarcoma in a patient with Paget disease of bone. Tables list epidemiologic features of sarcomas, a summary of sarcomas by histology, familial syndromes associated with increased risk of sarcoma, survival rates in sarcoma patients, staging of soft tissue sarcomas, and results of a meta-analysis of doxorubicin-based adjuvant chemotherapy for localized resectable soft tissue sarcoma. This chapter contains 126 references.

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Sarcomas of the Soft Tissue and Bone

10.2310/fm.1187 ◽

2011 ◽

Author(s):

Adam Lerner ◽

Huihong Xu ◽

Karen H Antman

Keyword(s):

Soft Tissue ◽

Meta Analysis ◽

Survival Rates ◽

Fibrous Tissue ◽

Soft Tissue Sarcomas ◽

Kaposi Sarcoma ◽

Uterine Leiomyosarcoma ◽

Increased Risk ◽

Bone Sarcomas ◽

Epidemiologic Features

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Oral soft tissue lesions in Greek children and adolescents

Journal of Clinical Pediatric Dentistry ◽

10.17796/jcpd.29.2.21184130718243r2 ◽

2005 ◽

Vol 29 (2) ◽

pp. 175-178 ◽

Cited By ~ 12

Author(s):

Alexandra Sklavounou-Andrikopoulou ◽

Evangelia Piperi ◽

Vassilis Papanikolaou ◽

Ion Karakoulakis

Keyword(s):

Soft Tissue ◽

Children And Adolescents ◽

Clinical Characteristics ◽

Oral Pathology ◽

Systemic Diseases ◽

Benign Lesions ◽

Inflammatory Lesions ◽

Soft Tissue Lesions ◽

Common Causes ◽

Oral Soft Tissue

Pediatric oral pathology encompasses a wide clinical spectrum of local and systemic diseases. The purpose of this study was to evaluate the clinical characteristics of oral soft tissue lesions in Greek children and adolescents up to 18 years old. Data available through a 32 year old period revealed that among the 1040 cases analyzed, benign lesions, mainly cysts, inflammatory lesions and reactive hyperplasias, were the most common causes for seeking dental advice during childhood. J Clin Pediatr Dent 29(2): 175-178, 2005.

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Epidemiology of Adult Soft-Tissue Sarcomas in Germany

Sarcoma ◽

10.1155/2018/5671926 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 8

Author(s):

Catherine W. Saltus ◽

Brian Calingaert ◽

Sean Candrilli ◽

Maria Lorenzo ◽

Yulia D’yachkova ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcomas ◽

Kaposi Sarcoma ◽

Cancer Registries ◽

German Population ◽

Cancer Registry Data ◽

Not Otherwise Specified ◽

Number Of Patients ◽

Specific Mortality ◽

Using Data

We conducted a retrospective cohort study using data compiled from the regional German cancer registries by the Centre for Cancer Registry Data (ZfKD) at the Robert Koch Institut (RKI) to describe the epidemiology of adult soft-tissue sarcomas (STS) in Germany in 2003–2012, focusing on advanced STS. We identified 33,803 incident adult cases of STS (other than the Kaposi sarcoma and gastrointestinal stromal tumors). The incidence of STS was 6.05 (95% confidence interval (CI), 5.82–6.29) per 100,000 in 2012 (4,079 cases). During 2003–2012, the most common histologic categories were leiomyosarcoma (19%), liposarcoma (16%), and STS not otherwise specified (14%). The overall STS-specific mortality rate in 2012 was 2.31 (95% CI, 2.06–2.57) per 100,000, and the median overall survival from initial diagnosis was 5.83 (95% CI, 5.50–6.08) years. Using STS mortality rates as a proxy for incidence of advanced STS in Germany and applying the age- and sex-specific rates to the corresponding German population, we estimated that 1,581 incident adult advanced STS cases occurred in Germany in 2012. Our findings contribute to a refined understanding of the population burden of STS in Germany, including the number of patients with advanced STS who may be candidates for systemic treatment.

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