scholarly journals Body Mass Index Is Not a Risk Factor for Unstable Angina and Myocardial Infarction in Veteran Patients With Angiographically Confirmed Coronary Artery Disease

Circulation ◽  
2004 ◽  
Vol 109 (18) ◽  
Author(s):  
Julio A. Chirinos ◽  
Juan P. Zambrano ◽  
Anila Veerani
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Risk Factor ◽  
Coronary Artery ◽  
Unstable Angina ◽  
Body Mass ◽  
Artery Disease

Association of Body Mass Index with Angiographic Severity of Coronary Artery Disease in Patients with Acute ST- Segment Elevation Myocardial Infarction

2017 ◽  
Vol 10 (1) ◽  
pp. 68-73
Author(s):  
Khondker Rafiquzzaman ◽  
Mahboob Ali ◽  
Md Toufiqur Rahman ◽  
Nur Alam ◽  
Muhammad Azmol Hossain ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
The Mean ◽  
Artery Disease

Background: This study evaluated the association of body mass index (BMI) and angiographic severity of coronary artery disease in patients with acute ST segment elevation myocardial infarction (STEMI).Methods: Data were analyzed from 100 acute STEMI patients who underwent coronary angiogram. The patients were grouped based on BMI; those with normal BMI, 18.5- 24.9 kg/m2 (group I) and those with increased BMI, >25 kg/m2 (group II). Each group contained 50 patients. Angiographic severity of the three groups was compared and the relation between BMI and angiographic severity was assessed.Results: The mean BMI of subjects with normal angiographic findings was 20.81 ± 1.03 kg/m2. The mean BMI of single, double and triple vessel disease were 23.85 ± 2.24, 24.25 ± 2.41 and 32.06 ± 7.86 kg/m2 respectively. The number of vessel involvement increased in proportion with increased BMI and the differences were statistically significant (p=0.001).Conclusion: Increased BMI is associated with angiographic severity of coronary artery disease in patients with acute ST-segment elevation myocardial infarction.Cardiovasc. j. 2017; 10(1): 68-73

scholarly journals Inverted U-shaped relationship between body mass index and multivessel lesions in Chinese patients with myocardial infarction: a cross-sectional study

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093282
Author(s):  
Dandan Sun ◽  
Wei Li ◽  
Hongmin Zhang ◽  
Yafen Li ◽  
Qingyun Zhang
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Multivessel Coronary Artery Disease ◽  
Artery Disease

Objective To investigate the association of body mass index (BMI) with multivessel coronary artery disease in patients with myocardial infarction. Methods This study was performed in 1566 patients with myocardial infarction in the Department of Cardiology, Affiliated Hospital of Jining Medical University, China. Independent and dependent variables were BMI measured at baseline and multivessel coronary artery disease, respectively. The covariates examined in this study were age, systolic blood pressure, diastolic blood pressure, heart rate, creatinine, uric acid, bilirubin, cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, left ventricular ejection fraction, sex, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, stroke, hypertension, diabetes mellitus, and smoking. Results A nonlinear relationship was detected between BMI and multivessel coronary artery disease, and this was an inverted U-shaped curve and the cutoff point was 26.3 kg/m2. The effect sizes and confidence intervals on the left and right sides of the inflection point were 1.10 (1.01–1.20) and 0.85 (0.74–0.97), respectively. Conclusions There is an obesity paradox for BMI > 26.3 kg/m2. Future studies should examine the relationship between BMI and prognosis in patients with myocardial infarction, which may be important for improving the prognosis through control of BMI.

449-P: Impact of Body Mass Index (BMI) and Waist Circumference (WC) on Coronary Artery Disease (CAD) in Japanese with and without Diabetes Mellitus (DM)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 449-P
Author(s):  
TAKESHI KOMATSU ◽  
KAZUYA FUJIHARA ◽  
MAYUKO H. YAMADA ◽  
TAKAAKI SATO ◽  
MASARU KITAZAWA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Waist Circumference ◽  
Body Mass ◽  
Artery Disease

Prospective Analysis after Coronary-artery Bypass Grafting: Platelet GP IIIa Polymorphism (HPA-1b /PlA2) Is a Risk Factor for Bypass Occlusion, Myocardial Infarction, and Death

2000 ◽  
Vol 83 (03) ◽  
pp. 404-407 ◽  
Author(s):  
Michael Klein ◽  
Hans Dauben ◽  
Christiane Moser ◽  
Emmeran Gams ◽  
Rüdiger Scharf ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Odds Ratio ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Hereditary Risk ◽  
Artery Disease

SummaryRecently, we have demonstrated that human platelet antigen 1b (HPA-1b or PlA2) is a hereditary risk factor for platelet thrombogenicity leading to premature myocardial infarction in preexisting coronary artery disease. However, HPA-1b does not represent a risk factor for coronary artery disease itself. The aim of our present study was to evaluate the role of HPA-1b on the outcome in patients after coronaryartery bypass surgery. We prospectively determined the HPA-1 genotype in 261 consecutive patients prior to saphenous-vein coronaryartery bypass grafting. The patients were followed for one year. Among patients with bypass occlusion, myocardial infarction, or death more than 30 days after surgery, the prevalence of HPA-1b was significantly higher than among patients without postoperative complications (60 percent, 6/10, vs. 24 percent, 58/241, p <0.05, odds ratio 4.7). Using a stepwise logistic regression analysis with the variables HPA1b, age, sex, body mass index, smoking (pack-years), hypertension, diabetes, cholesterol and triglyceride concentration, only HPA-1b had a significant association with bypass occlusion, myocardial infarction, or death after bypass surgery (p = 0.019, odds ratio 4.7). This study shows that HPA-1b is a hereditary risk factor for bypass occlusion, myocardial infarction, or death in patients after coronary-artery bypass surgery.

Abstract 3118: Combined Assessment of Intima-Media Thickness and Echolucency of an Atherosclerotic Plaque in Carotid Artery has an Additive Value on Prediction of Future Coronary Events in Patients with Coronary Artery Disease and Carotid Atherosclerosis

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Mitsumasa Hirano ◽  
Takamitsu Nakamura ◽  
Yoshinobu Kitta ◽  
Isao Takishima ◽  
Aritaka Makino ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Unstable Angina ◽  
Cardiac Death ◽  
Intima Media Thickness ◽  
Ultrasound Assessment ◽  
Coronary Events ◽  
Artery Disease

Single ultrasound assessment of either intima-media thickness (IMT) or plaque echolucency of carotid artery is considered a surrogate for systemic atherosclerotic burden and provides prognostic information for coronary events. The assessment of IMT and plaque echolucency of carotid artery has the advantage of obtaining structural and compositional information on atherosclerotic plaques in a single session. This study examined the hypothesis that the combined ultrasound assessment of IMT and echolucency in a carotid artery may have an additive effect on the prediction of coronary events in patients with coronary artery disease (CAD). Ultrasound assessment of carotid IMT and plaque echolucency with integrated backscatter (IBS) analysis (intima-media IBS value minus adventitia IBS) was performed in 411 patients with CAD and carotid plaques (IMT ≥ 1.1 mm). The plaque with the greatest axial thickness in carotid arteries was the target for measurement of maximum IMT (plaque-IMTmax) and echolucency (lower IBS reflects echolucent plaque). All patients were prospectively followed up for 70 months or until the occurrence of one of the following coronary events: cardiac death, nonfatal myocardial infarction, or unstable angina pectoris requiring revascularization. During follow-up, 49 coronary events occurred (cardiac death in 2, myocardial infarction in 10, unstable angina in 37). In a multivariate Cox hazards analysis, plaque-IMTmax and plaque echolucency (lower IBS value) were significant predictors of coronary events (HR; 1.82 and 0.85, 95% CI 1.2 – 2.9 and 0.80 – 0.91, respectively, both p < 0.01) independently of age, LDL-C levels, and diabetes. When outcomes were stratified according to plaque-IMTmax and plaque echolucency in combination or alone, the combination of plaque-IMTmax and plaque echolucency was the strongest predictor of events, followed by plaque echolucency and plaque-IMTmax, on the basis of the c -statistic (area under the ROC curve; 0.80, 0.73, and 0.71, respectively). Combined ultrasound assessment of IMT and echolucency of carotid plaque had an additive value on the prediction of coronary events, and these simultaneous ultrasound measurements may be useful for risk stratification in CAD.

scholarly journals The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Anne B. Gregory ◽  
Kendra K. Lester ◽  
Deborah M. Gregory ◽  
Laurie K. Twells ◽  
William K. Midodzi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Cardiac Risk ◽  
Cardiac Risk Factor ◽  
Increased Risk ◽  
Specific Mortality ◽  
Artery Disease ◽  
The Relationship

Background and Aim. Obesity is associated with an increased risk of cardiovascular disease and may be associated with more severe coronary artery disease (CAD); however, the relationship between body mass index [BMI (kg/m2)] and CAD severity is uncertain and debatable. The aim of this study was to examine the relationship between BMI and angiographic severity of CAD. Methods. Duke Jeopardy Score (DJS), a prognostic tool predictive of 1-year mortality in CAD, was assigned to angiographic data of patients ≥18 years of age (N=8,079). Patients were grouped into 3 BMI categories: normal (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥30 kg/m2); and multivariable adjusted hazard ratios for 1-year all-cause and cardiac-specific mortality were calculated. Results. Cardiac risk factor prevalence (e.g., diabetes, hypertension, and hyperlipidemia) significantly increased with increasing BMI. Unadjusted all-cause and cardiac-specific 1-year mortality tended to rise with incremental increases in DJS, with the exception of DJS 6 (p<0.001). After adjusting for potential confounders, no significant association of BMI and all-cause (HR 0.70, 95% CI .48–1.02) or cardiac-specific (HR 1.11, 95% CI .64–1.92) mortality was found. Conclusions. This study failed to detect an association of BMI with 1-year all-cause or cardiac-specific mortality after adjustment for potential confounding variables.

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