Elevated Serum Lipoprotein(a) Is a Risk Factor for Clinical Recurrence After Coronary Balloon Angioplasty

Circulation ◽  
1995 ◽  
Vol 91 (5) ◽  
pp. 1403-1409 ◽  
Author(s):  
Rene L. Desmarais ◽  
Ian J. Sarembock ◽  
Carlos R. Ayers ◽  
Sarah M. Vernon ◽  
Eric R. Powers ◽  
...  
Keyword(s):  
Risk Factor ◽  
Balloon Angioplasty ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Clinical Recurrence ◽  
Lipoprotein A

scholarly journals Elevated serum lipoprotein(a) as a risk factor for combined intracranial and extracranial artery stenosis in a child with arterial ischemic stroke

Medicine ◽  
2017 ◽  
Vol 96 (49) ◽  
pp. e9025 ◽  
Author(s):  
Ji Yoon Han ◽  
Hyun Jeong Kim ◽  
Soyoung Shin ◽  
Joonhong Park ◽  
In Goo Lee
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Artery Stenosis ◽  
Arterial Ischemic Stroke ◽  
Lipoprotein A

scholarly journals Elevated serum lipoprotein(a) is significantly associated with angiographic progression of coronary artery disease

2021 ◽  
Author(s):  
Xing Shui ◽  
Zheqi Wen ◽  
Zefeng Chen ◽  
Xujing Xie ◽  
Yongxia Wu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Lipoprotein A ◽  
Artery Disease

scholarly journals Elevated Lipoprotein(a) Levels Lower ABCA1 Cholesterol Efflux Capacity

2019 ◽  
Vol 104 (10) ◽  
pp. 4793-4803 ◽  
Author(s):  
Hagai Tavori ◽  
Alexandra M Fenton ◽  
Deanna L Plubell ◽  
Sara Rosario ◽  
Elisabeth Yerkes ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Elevated Serum ◽  
Multiple Linear Regression Model ◽  
Serum Lipoprotein ◽  
Total Serum ◽  
Lipoprotein A ◽  
Cholesterol Efflux Capacity ◽  
Culture Models

Abstract Context Elevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. ABCA1-mediated cholesterol efflux from macrophages may be an antiatherogenic process. Plasminogen (PLG) is a driver of ABCA1-mediated cholesterol efflux, and its action is inhibited by purified human Lp(a). Objective To determine the effects of Lp(a) in human serum on ABCA1 cholesterol efflux. Methods Cholesterol efflux capacity (CEC) was measured with two different cell-culture models using serum from 76 patients with either low (<50 mg/dL) or high (>50 mg/dL) Lp(a) levels. Results Using cAMP-stimulated J774 macrophages or baby hamster kidney fibroblasts overexpressing human ABCA1, we show that CEC was lower in patients with high Lp(a) levels compared with patients with low levels (−30.6%, P = 0.002 vs −24.1%, P < 0.001, respectively). Total-serum CEC negatively correlated with Lp(a) levels (r = −0.433, P = 0.0007 vs r = −0.505, P = 0.0011, respectively). These negative associations persisted after adjusting for serum cholesterol, age, sex, and statin use in a multiple linear regression model (adjusted R2 = 0.413 or 0.405, respectively) and were strengthened when further adjusting for the interaction between Lp(a) and PLG levels (adjusted R2 = 0.465 and 0.409, respectively). Total-serum and isolated Lp(a) from patients with high Lp(a) inhibited PLG-mediated ABCA1 cholesterol efflux. Conclusion Total-serum CEC is reduced in patients with high Lp(a) levels. This is in part due to the inhibition of PLG-mediated ABCA1 cholesterol efflux by Lp(a). Our findings suggest an atherogenic role for Lp(a) through its ability to inhibit CEC.

Elevated serum lipoprotein(a) in subclinical hypothyroidism

1995 ◽  
Vol 43 (4) ◽  
pp. 445-449 ◽  
Author(s):  
A. W. C. Kung ◽  
R. W. C. Pang ◽  
E. D. Janus
Keyword(s):  
Subclinical Hypothyroidism ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Lipoprotein A

Elevated serum lipoprotein(a) levels in young women with endometriosis

Metabolism ◽  
1997 ◽  
Vol 46 (7) ◽  
pp. 735-739 ◽  
Author(s):  
David Crook ◽  
Rosemary Howell ◽  
Mandeep Sidhu ◽  
D.Keith Edmonds ◽  
John C. Stevenson
Keyword(s):  
Young Women ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Lipoprotein A

Impact of markedly elevated serum lipoprotein(a) levels (≥100 mg/dL) on the risk of coronary heart disease

Metabolism ◽  
2007 ◽  
Vol 56 (9) ◽  
pp. 1187-1191 ◽  
Author(s):  
Toshio Murase ◽  
Minoru Okubo ◽  
Michiyo Amemiya-Kudo ◽  
Takaki Hiraga ◽  
Junko Oka ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Lipoprotein A
Sign in / Sign up

Export Citation Format

Share Document