scholarly journals Elevated serum lipoprotein(a) as a risk factor for combined intracranial and extracranial artery stenosis in a child with arterial ischemic stroke

Medicine ◽  
2017 ◽  
Vol 96 (49) ◽  
pp. e9025 ◽  
Author(s):  
Ji Yoon Han ◽  
Hyun Jeong Kim ◽  
Soyoung Shin ◽  
Joonhong Park ◽  
In Goo Lee
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Artery Stenosis ◽  
Arterial Ischemic Stroke ◽  
Lipoprotein A

Elevated Serum Lipoprotein(a) Is a Risk Factor for Clinical Recurrence After Coronary Balloon Angioplasty

Circulation ◽  
1995 ◽  
Vol 91 (5) ◽  
pp. 1403-1409 ◽  
Author(s):  
Rene L. Desmarais ◽  
Ian J. Sarembock ◽  
Carlos R. Ayers ◽  
Sarah M. Vernon ◽  
Eric R. Powers ◽  
...  
Keyword(s):  
Risk Factor ◽  
Balloon Angioplasty ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Clinical Recurrence ◽  
Lipoprotein A

scholarly journals Lipoprotein (a) Levels in Childhood Arterial Ischemic Stroke

2009 ◽  
Vol 16 (2) ◽  
pp. 214-217 ◽  
Author(s):  
Serap Teber ◽  
Gülhis Deda ◽  
Nejat Akar ◽  
Kazım Soylu
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Young Patients ◽  
Control Group ◽  
Healthy Children ◽  
Case Control Studies ◽  
Arterial Ischemic Stroke ◽  
Lipoprotein A ◽  
Screening Programs ◽  
Stroke In Young Adults

Lipoprotein (a) is a cholesterol-rich plasma lipoprotein with a lipid composition similar to that of low-density lipoproteins (LDL). Many prospective and case-control studies identified elevated levels of lipoprotein (a) as a risk factor for premature myocardial infarction and stroke. Elevated lipoprotein (a) has been identified as a genetically determined risk factor for stroke in young adults, but only preliminary data are available on its role as a risk factor for ischemic stroke in infants and children. Fifty two children with arterial ischemic stroke and 78 age- and sex-matched healthy children were studied. Data of this study indicate that 26.9% of children with arterial ischemic stroke had high lipoprotein (a) levels in comparison with the age matched healthy control group. Measurement of lipoprotein (a) should be included in screening programs performed in young patients suffering not only from venous thromboembolism but also arterial ischemic stroke, in addition to other thrombophilic factors.

scholarly journals Relationship Between Lipoprotein (a) [Lp(a)] and Cognition in Different Ischemic Stroke Subtypes

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingjing Li ◽  
Shiyu Li ◽  
Yuesong Pan ◽  
Mengxing Wang ◽  
Xia Meng ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Elevated Serum ◽  
Serum Lipoprotein ◽  
Lower Percentage ◽  
Secondary Outcome ◽  
Large Artery ◽  
Lipoprotein A ◽  
Small Artery Occlusion

Background and Purpose: Although elevated serum lipoprotein (a) [Lp(a)] is considered to be a risk factor of ischemic stroke, the relationship between Lp(a) and cognitive impairment after stroke remains unclear. This study investigated the association between serum Lp(a) and cognitive function after acute ischemic stroke (AIS) or transient ischemic attack (TIA).Methods: The study included 1,017 patients diagnosed with AIS or TIA from the cognition subgroup of the Third China National Stroke Registry (CNSR3). Montreal Cognitive Assessment (MoCA) at 2 weeks or discharge, 3 months, and 1 year was evaluated. The primary outcome was cognitive impairment at 1 year, defined as MoCA ≤ 22. The secondary outcome was cognition improvement at 1 year compared with 2 weeks. The association between Lp(a) levels and cognitive function was analyzed.Results: Among the 1,017 patients included, 326 (32.1%) had cognitive impairment at 1 year. Patients with MoCA ≤ 22 at 1 year were older, received less education, and had higher baseline NIHSS, higher proportion of ischemic stroke history, large artery atherosclerosis (LAA) subtype, and multiple infarctions (P < 0.05 for all). Patients with highest Lp(a) quartile had slightly higher percentage of cognitive impairment at 1 year but without statistical difference. In subgroup analysis of LAA subtype, the patients with highest Lp(a) quartile had higher percentage of cognitive impairment at 1 year (adjusted OR:2.63; 95% CI: 1.05–6.61, P < 0.05). What is more, the patients with highest Lp(a) quartile in LAA subtype had lower percentage of cognition improvement at 1 year. However, similar results were not found in small artery occlusion (SAO) subtype.Conclusion: Higher Lp(a) level was associated with cognitive impairment and less improvement of cognition in patients after AIS or TIA with large-artery atherosclerosis subtype.

scholarly journals Elevated Lipoprotein(a) Levels Lower ABCA1 Cholesterol Efflux Capacity

2019 ◽  
Vol 104 (10) ◽  
pp. 4793-4803 ◽  
Author(s):  
Hagai Tavori ◽  
Alexandra M Fenton ◽  
Deanna L Plubell ◽  
Sara Rosario ◽  
Elisabeth Yerkes ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Elevated Serum ◽  
Multiple Linear Regression Model ◽  
Serum Lipoprotein ◽  
Total Serum ◽  
Lipoprotein A ◽  
Cholesterol Efflux Capacity ◽  
Culture Models

Abstract Context Elevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. ABCA1-mediated cholesterol efflux from macrophages may be an antiatherogenic process. Plasminogen (PLG) is a driver of ABCA1-mediated cholesterol efflux, and its action is inhibited by purified human Lp(a). Objective To determine the effects of Lp(a) in human serum on ABCA1 cholesterol efflux. Methods Cholesterol efflux capacity (CEC) was measured with two different cell-culture models using serum from 76 patients with either low (<50 mg/dL) or high (>50 mg/dL) Lp(a) levels. Results Using cAMP-stimulated J774 macrophages or baby hamster kidney fibroblasts overexpressing human ABCA1, we show that CEC was lower in patients with high Lp(a) levels compared with patients with low levels (−30.6%, P = 0.002 vs −24.1%, P < 0.001, respectively). Total-serum CEC negatively correlated with Lp(a) levels (r = −0.433, P = 0.0007 vs r = −0.505, P = 0.0011, respectively). These negative associations persisted after adjusting for serum cholesterol, age, sex, and statin use in a multiple linear regression model (adjusted R2 = 0.413 or 0.405, respectively) and were strengthened when further adjusting for the interaction between Lp(a) and PLG levels (adjusted R2 = 0.465 and 0.409, respectively). Total-serum and isolated Lp(a) from patients with high Lp(a) inhibited PLG-mediated ABCA1 cholesterol efflux. Conclusion Total-serum CEC is reduced in patients with high Lp(a) levels. This is in part due to the inhibition of PLG-mediated ABCA1 cholesterol efflux by Lp(a). Our findings suggest an atherogenic role for Lp(a) through its ability to inhibit CEC.

scholarly journals Predictors of Cholesterol and Lipoprotein(a) Testing in Children with Arterial Ischemic Stroke

2014 ◽  
Vol 23 (9) ◽  
pp. 2405-2413 ◽  
Author(s):  
Sally Sultan ◽  
Nicole Schupf ◽  
Michael Dowling ◽  
Gabrielle DeVeber ◽  
Adam Kirton ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Arterial Ischemic Stroke ◽  
Lipoprotein A
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