Time Course of Maternal Plasma Volume and Hormonal Changes in Women With Preeclampsia or Fetal Growth Restriction

Background: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and pregnancy outcomes. Objective: In this study, our aim was to evaluate the association of maternal plasma levels of FA with fetal growth restriction (FGR). Materials and Methods: 41 pregnant women with FGR and 40 controls were recruited in this case-control study between July and November 2015. At the diagnosis of FGR, venous blood samples (10 cc) were obtained for FA analysis. Results: Maternal plasma FA levels were significantly higher in fetal growth-restricted pregnant women compared with controls (19.3 ± 3.0 ng/ml vs 25.9 ± 6.8 ng/ml, p = 0.001). Area under receiver operating characteristic curve analysis of FA in FGR was 0.815 (95% confidence interval (CI): 0.718-0.912, p < 0.001). The maternal FA levels with values more than 22.5 ng/ml had a sensitivity of about 73.17% (95% CI: 56.79- 85.25) and a specificity of about 82.5% (95% CI: 66.64-92.11) with positive and negative predictive values of about 81.08% (95% CI: 64.29-91.45) and 75% (95% CI: 59.35-86.30), respectively. Therefore, the diagnostic accuracy was obtained about 77.78%. Conclusion: The results of this study show higher maternal plasma levels of FA in FGR. Further studies are needed in order to demonstrate the long-term effects of FA in pregnancies complicated with FGR and early prediction of FGR.

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Altered proteome profiles in maternal plasma in pregnancies with fetal growth restriction

Clinical Proteomics ◽

10.1007/bf02752499 ◽

2006 ◽

Vol 2 (3-4) ◽

pp. 169-184 ◽

Cited By ~ 8

Author(s):

Madhulika B. Gupta ◽

Maxim D. Seferovic ◽

Suya Liu ◽

Robert J. Gratton ◽

Amanda Doherty-Kirby ◽

...

Keyword(s):

Fetal Growth ◽

Fetal Growth Restriction ◽

Maternal Plasma ◽

Growth Restriction

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Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?

Amino Acids ◽

10.1007/s00726-017-2522-2 ◽

2017 ◽

Vol 50 (2) ◽

pp. 341-351 ◽

Cited By ~ 7

Author(s):

Dimitrios Tsikas ◽

Alexander Bollenbach ◽

Makrina D. Savvidou

Keyword(s):

Fetal Growth ◽

Fetal Growth Restriction ◽

Asymmetric Dimethylarginine ◽

Inverse Correlation ◽

Maternal Plasma ◽

Growth Restriction ◽

Placental Perfusion ◽

Independent Indicator

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Identification and Characterization of Extrachromosomal Circular DNA in Human Placentas With Fetal Growth Restriction

Frontiers in Immunology ◽

10.3389/fimmu.2021.780779 ◽

2021 ◽

Vol 12 ◽

Author(s):

Huan Yang ◽

Jie He ◽

Shuai Huang ◽

Hongbing Yang ◽

Qingjie Yi ◽

...

Keyword(s):

Fetal Growth ◽

Fetal Growth Restriction ◽

Enrichment Analysis ◽

Maternal Plasma ◽

Growth Restriction ◽

Formation Mechanisms ◽

Pathway Enrichment Analysis ◽

Circular Dnas ◽

New Biomarkers ◽

Host Genes

Many studies have confirmed that extrachromosomal circular DNAs (eccDNAs/ecDNAs) exist in tumor and normal cells independently of the chromosome and are essential for oncogene plasticity and drug resistance. Studies have confirmed that there are many eccDNAs/ecDNAs in maternal plasma derived from the fetus. Fetal growth restriction (FGR) is a pregnancy-related disease associated with high newborn morbidity and mortality. However, the characteristics and nature of eccDNAs/ecDNAs in FGR are poorly understood. This study aims to deconstruct the properties and potential functions of eccDNAs/ecDNAs in FGR. We performed circle-seq to identify the expression profile of eccDNAs/ecDNAs, analyzed by bioinformatics, and verified by real-time Polymerase Chain Reaction (PCR) combined with southern blot in FGR compared with the normal groups. A total of 45,131 eccDNAs/ecDNAs (including 2,118 unique ones) were identified, which had significantly higher abundance in FRG group than in normal group, and was bimodal in length, peaking at ~146bp and ~340bp, respectively. Gestational age may be one independent factor affecting the production of eccDNAs/ecDNAs, most of which come from genomic regions with high gene density, with a 4~12bp repeat around the junction, and their origin had a certain genetic preference. In addition, some of the host-genes overlapped with non-coding RNAs (ncRNAs) partially or even completely. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that host-genes on the differentially expressed eccDNAs/ecDNAs (DEEECs/DEECs) were mainly enriched in immune-related functions and pathways. The presence of some ecDNAs were verified, and whose variability were consistent with the circle-seq results. We identified and characterized eccDNAs/ecDNAs in placentas with FGR, and elucidated the formation mechanisms and the networks with ncRNAs, which provide a new vision for the screening of new biomarkers and therapeutic targets for FGR.

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