Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia

2016 ◽  
Vol 30 (6) ◽  
pp. 635-639 ◽  
Author(s):  
Kirsten R. Palmer ◽  
Tu’uhevaha J. Kaitu’u-Lino ◽  
Ping Cannon ◽  
Laura Tuohey ◽  
Manarangi S. De Silva ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Growth Restriction

scholarly journals Enhanced Nitrite-Mediated Relaxation of Placental Blood Vessels Exposed to Hypoxia Is Preserved in Pregnancies Complicated by Fetal Growth Restriction

2021 ◽  
Vol 22 (9) ◽  
pp. 4500
Author(s):  
Teresa Tropea ◽  
Carina Nihlen ◽  
Eddie Weitzberg ◽  
Jon O. Lundberg ◽  
Mark Wareing ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Vessels ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Plasma Concentrations ◽  
Growth Restriction ◽  
Alternative Source ◽  
Fetal Plasma ◽  
Placental Blood ◽  
Nitrate And Nitrite

Nitric oxide (NO) is essential in the control of fetoplacental vascular tone, maintaining a high flow−low resistance circulation that favors oxygen and nutrient delivery to the fetus. Reduced fetoplacental blood flow is associated with pregnancy complications and is one of the major causes of fetal growth restriction (FGR). The reduction of dietary nitrate to nitrite and subsequently NO may provide an alternative source of NO in vivo. We have previously shown that nitrite induces vasorelaxation in placental blood vessels from normal pregnancies, and that this effect is enhanced under conditions of hypoxia. Herein, we aimed to determine whether nitrite could also act as a vasodilator in FGR. Using wire myography, vasorelaxant effects of nitrite were assessed on pre-constricted chorionic plate arteries (CPAs) and veins (CPVs) from normal and FGR pregnancies under normoxic and hypoxic conditions. Responses to the NO donor, sodium nitroprusside (SNP), were assessed in parallel. Nitrate and nitrite concentrations were measured in fetal plasma. Hypoxia significantly enhanced vasorelaxation to nitrite in FGR CPAs (p < 0.001), and in both normal (p < 0.001) and FGR (p < 0.01) CPVs. Vasorelaxation to SNP was also potentiated by hypoxia in both normal (p < 0.0001) and FGR (p < 0.01) CPVs. However, compared to vessels from normal pregnancies, CPVs from FGR pregnancies showed significantly lower reactivity to SNP (p < 0.01). Fetal plasma concentrations of nitrate and nitrite were not different between normal and FGR pregnancies. Together, these data show that nitrite-mediated vasorelaxation is preserved in FGR, suggesting that interventions targeting this pathway have the potential to improve fetoplacental blood flow in FGR pregnancies.

scholarly journals Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study

2019 ◽  
Author(s):  
Mujde Can Ibano ◽  
Cem Yasar Sanhal ◽  
Seval Ozgu-Erdinc ◽  
Aykan Yucel
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Plasma Levels ◽  
Case Control Study ◽  
Maternal Plasma ◽  
Case Control ◽  
Growth Restriction ◽  
Fetuin A ◽  
Control Study

Background: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and pregnancy outcomes. Objective: In this study, our aim was to evaluate the association of maternal plasma levels of FA with fetal growth restriction (FGR). Materials and Methods: 41 pregnant women with FGR and 40 controls were recruited in this case-control study between July and November 2015. At the diagnosis of FGR, venous blood samples (10 cc) were obtained for FA analysis. Results: Maternal plasma FA levels were significantly higher in fetal growth-restricted pregnant women compared with controls (19.3 ± 3.0 ng/ml vs 25.9 ± 6.8 ng/ml, p = 0.001). Area under receiver operating characteristic curve analysis of FA in FGR was 0.815 (95% confidence interval (CI): 0.718-0.912, p < 0.001). The maternal FA levels with values more than 22.5 ng/ml had a sensitivity of about 73.17% (95% CI: 56.79- 85.25) and a specificity of about 82.5% (95% CI: 66.64-92.11) with positive and negative predictive values of about 81.08% (95% CI: 64.29-91.45) and 75% (95% CI: 59.35-86.30), respectively. Therefore, the diagnostic accuracy was obtained about 77.78%. Conclusion: The results of this study show higher maternal plasma levels of FA in FGR. Further studies are needed in order to demonstrate the long-term effects of FA in pregnancies complicated with FGR and early prediction of FGR.

scholarly journals Altered proteome profiles in maternal plasma in pregnancies with fetal growth restriction

2006 ◽  
Vol 2 (3-4) ◽  
pp. 169-184 ◽  
Author(s):  
Madhulika B. Gupta ◽  
Maxim D. Seferovic ◽  
Suya Liu ◽  
Robert J. Gratton ◽  
Amanda Doherty-Kirby ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Maternal Plasma ◽  
Growth Restriction

scholarly journals Identification and Characterization of Extrachromosomal Circular DNA in Human Placentas With Fetal Growth Restriction

2021 ◽  
Vol 12 ◽  
Author(s):  
Huan Yang ◽  
Jie He ◽  
Shuai Huang ◽  
Hongbing Yang ◽  
Qingjie Yi ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Enrichment Analysis ◽  
Maternal Plasma ◽  
Growth Restriction ◽  
Formation Mechanisms ◽  
Pathway Enrichment Analysis ◽  
Circular Dnas ◽  
New Biomarkers ◽  
Host Genes

Many studies have confirmed that extrachromosomal circular DNAs (eccDNAs/ecDNAs) exist in tumor and normal cells independently of the chromosome and are essential for oncogene plasticity and drug resistance. Studies have confirmed that there are many eccDNAs/ecDNAs in maternal plasma derived from the fetus. Fetal growth restriction (FGR) is a pregnancy-related disease associated with high newborn morbidity and mortality. However, the characteristics and nature of eccDNAs/ecDNAs in FGR are poorly understood. This study aims to deconstruct the properties and potential functions of eccDNAs/ecDNAs in FGR. We performed circle-seq to identify the expression profile of eccDNAs/ecDNAs, analyzed by bioinformatics, and verified by real-time Polymerase Chain Reaction (PCR) combined with southern blot in FGR compared with the normal groups. A total of 45,131 eccDNAs/ecDNAs (including 2,118 unique ones) were identified, which had significantly higher abundance in FRG group than in normal group, and was bimodal in length, peaking at ~146bp and ~340bp, respectively. Gestational age may be one independent factor affecting the production of eccDNAs/ecDNAs, most of which come from genomic regions with high gene density, with a 4~12bp repeat around the junction, and their origin had a certain genetic preference. In addition, some of the host-genes overlapped with non-coding RNAs (ncRNAs) partially or even completely. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that host-genes on the differentially expressed eccDNAs/ecDNAs (DEEECs/DEECs) were mainly enriched in immune-related functions and pathways. The presence of some ecDNAs were verified, and whose variability were consistent with the circle-seq results. We identified and characterized eccDNAs/ecDNAs in placentas with FGR, and elucidated the formation mechanisms and the networks with ncRNAs, which provide a new vision for the screening of new biomarkers and therapeutic targets for FGR.

scholarly journals Time Course of Maternal Plasma Volume and Hormonal Changes in Women With Preeclampsia or Fetal Growth Restriction

Hypertension ◽  
2006 ◽  
Vol 47 (2) ◽  
pp. 203-208 ◽  
Author(s):  
Sofía P. Salas ◽  
Guillermo Marshall ◽  
Blanca L. Gutiérrez ◽  
Pedro Rosso
Keyword(s):  
Fetal Growth ◽  
Plasma Volume ◽  
Fetal Growth Restriction ◽  
Time Course ◽  
Maternal Plasma ◽  
Growth Restriction ◽  
Hormonal Changes

scholarly journals 379 Maternal Plasma Urocortin I Levels in Preeclampsia and Fetal Growth Restriction Predict Neonatal Intraventricular Haemorrhage

2005 ◽  
Vol 58 (2) ◽  
pp. 419-419
Author(s):  
M Torricelli ◽  
P Florio ◽  
A Giovannelli ◽  
P B Torres ◽  
A Dell'Anna ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Intraventricular Haemorrhage ◽  
Maternal Plasma ◽  
Growth Restriction

Predictive value of testing for maternal plasma cell-free fetal DNA in fetal growth restriction

2021 ◽  
Vol 6_2021 ◽  
pp. 60-65
Author(s):  
Kan N.E. Kan ◽  
Tyutyunnik V.L. Tyutyunnik ◽  
Khachatryan Z.V. Khachatryan ◽  
Sadekova A.A. Sadekova ◽  
Krasnyi A.M. Krasnyi ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Fetal Growth ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Maternal Plasma ◽  
Growth Restriction ◽  
Fetal Dna ◽  
Cell Free Fetal Dna

Placental uptake and transport of ACP, a neutral nonmetabolizable amino acid, in an ovine model of fetal growth restriction

2004 ◽  
Vol 287 (6) ◽  
pp. E1114-E1124 ◽  
Author(s):  
Barbra de Vrijer ◽  
Timothy R. H. Regnault ◽  
Randall B. Wilkening ◽  
Giacomo Meschia ◽  
Frederick C. Battaglia
Keyword(s):  
Amino Acid ◽  
Fetal Growth ◽  
Amino Acid Transport ◽  
Fetal Growth Restriction ◽  
Plasma Concentrations ◽  
Growth Restriction ◽  
Acid Transport ◽  
Ovine Model ◽  
Fetal Plasma ◽  
Branched Chain

Reductions in fetal plasma concentrations of certain amino acids and reduced amino acid transport in vesicle studies suggest impaired placental amino acid transport in human fetal growth restriction (FGR). In the present study, we tested the hypothesis of an impairment in amino acid transport in the ovine model of hyperthermia-induced FGR by determining transplacental and placental retention and total placental clearance of a branched-chain amino acid (BCAA) analog, the nonmetabolizable neutral amino acid aminocyclopentane-1-carboxylic acid (ACP), in singleton control (C) and FGR pregnancies at 135 days gestation age (dGA; term 147 dGA). At study, based on the severity of the placental dysfunction, FGR fetuses were allocated to severe (sFGR, n = 6) and moderate FGR (mFGR, n = 4) groups. Fetal (C, 3,801.91 ± 156.83; mFGR, 2,911.33 ± 181.35; sFGR, 1,795.99 ± 238.85 g; P < 0.05) and placental weights (C, 414.38 ± 38.35; mFGR, 306.23 ± 32.41; sFGR, 165.64 ± 28.25 g; P < 0.05) were reduced. Transplacental and total placental clearances of ACP per 100 g placenta were significantly reduced in the sFGR but not in the mFGR group, whereas placental retention clearances were unaltered. These data indicate that both entry of ACP into the placenta and movement from the placenta into fetal circulation are impaired in severe ovine FGR and support the hypothesis of impaired placental BCAA transport in severe human FGR.

Sign in / Sign up

Export Citation Format

Share Document