Incidence and Short-Term Outcome of Cerebral Infarction in Young Adults in Western Norway

Purpose: We studied the association between admission white blood cell (WBC) count and short term outcome in patients with acute cerebral infarction. Methods: 2808 patients with acute cerebral infarction were included in the study. WBC count and other variables were collected within the first 24 hours of admission. Clinical outcomes (death or dependency) were evaluated by neurologists during hospitalization. The associations between WBC count and in-hospital death or dependency at discharge were analyzed using a multiple logistic model. Result: Multivariate-adjusted odds ratio (95% confidence intervals) of dependency associated with patients with WBC of 10.0-10.9×109/L, 11.0-11.9×109/L, ≥12.0×109/L were 1.46(0. 87-2. 45), 6.21(3. 70-10. 42) and 7.01(4. 53-10. 87), respectively, when compared with patients with admission WBC counts < 10.0x109/L. Multivariate-adjusted odds ratio (95% confidence intervals) of death associated with WBC 10.0-10.9×109/L, 11.0-11.9×109/L and ≥12.0×109/L were 2.098(0. 96-4. 58), 4.79(2. 24-10. 22) and 5.59(3. 14-9. 98), respectively. Conclusion: Increased WBC count at admission was significantly and positively associated with in-hospital death or dependency at discharge among patients with acute cerebral infarction.

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Preadmission Use of Warfarin Improves Short-Term Outcome in Patients with Acute Cerebral Infarction

Cerebrovascular Diseases ◽

10.1159/000215937 ◽

2009 ◽

Vol 28 (1) ◽

pp. 8-12 ◽

Cited By ~ 3

Author(s):

Halvor Naess ◽

Jan Brogger ◽

Ulrike Waje-Andreassen ◽

Titto T. Idicula ◽

Lars Thomassen

Keyword(s):

Cerebral Infarction ◽

Acute Cerebral Infarction ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Sex differences in risk factors, etiology, and short-term outcome of cerebral infarction in young patients

Atherosclerosis ◽

10.1016/j.atherosclerosis.2011.02.002 ◽

2011 ◽

Vol 216 (2) ◽

pp. 420-425 ◽

Cited By ~ 5

Author(s):

Bin Zhang ◽

ShuXiang Pu ◽

WeiZhi Zhang ◽

Ning Yang ◽

Gang Shen ◽

...

Keyword(s):

Risk Factors ◽

Sex Differences ◽

Cerebral Infarction ◽

Young Patients ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Evaluation of inflammatory markers and mean platelet volume as short-term outcome indicators in young adults with ischemic stroke

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-019-0123-6 ◽

2019 ◽

Vol 55 (1) ◽

Author(s):

Ahmed Dahshan ◽

Asmaa M. Ebraheim ◽

Laila A. Rashed ◽

Mohammed A. Farrag ◽

Ahmed T. El Ghoneimy

Keyword(s):

Young Adults ◽

Ischemic Stroke ◽

Mean Platelet Volume ◽

Unfavorable Outcome ◽

Stroke Severity ◽

Platelet Volume ◽

Short Term ◽

Term Outcome ◽

Infarction Size ◽

Short Term Outcome

Abstract Background Studying outcome predictors in patients with onset of cerebral infarction in early adult life may enhance our knowledge of disease pathophysiology and prognosis. Aim The aim is to identify independent predictors of short-term outcome of first-ever ischemic stroke in young adults with special emphasis on inflammatory and thrombogenic markers. Methods We enrolled 33 patients aged 19–44 years with first-ever ischemic stroke admitted to Kasr Alainy Stroke Unit and 33 matched controls. Clinical, radiological, and laboratory (adhesion molecules, C-reactive protein, prolactin, and mean platelet volume) evaluations were carried out. Functional outcome at 7 days after stroke onset was assessed using the modified Rankin scale, and independent predictors were identified. Results The most frequently identified risk factor was cardiac abnormality. Patients exhibited significantly higher levels of baseline inflammatory and thrombogenic markers compared with controls. These markers were significantly correlated with the stroke severity. Logistic regression model showed that high National Institutes of Health Stroke Scale (NIHSS) score (odds ratios [OR] = 0.13; 95% confidence interval [CI], 0.04–0.24; P = 0.01) and large infarction size (OR = 0.11; 95% CI, 0.09–0.17; P = 0.04) but not the laboratory markers were independent predictors of unfavorable outcome. Conclusion Our data suggested that higher NIHSS scores and large infarction size served as independent predictors of short-term unfavorable outcome, while inflammatory and thrombogenic markers did not.

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Persistent Atrial Fibrillation Is Associated with Worse Prognosis Than Paroxysmal Atrial Fibrillation in Acute Cerebral Infarction

ISRN Cardiology ◽

10.5402/2012/650915 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 8

Author(s):

Halvor Naess ◽

Ulrike Waje-Andreassen ◽

Lars Thomassen

Keyword(s):

Atrial Fibrillation ◽

Cerebral Infarction ◽

Persistent Atrial Fibrillation ◽

Stroke Onset ◽

Acute Cerebral Infarction ◽

Short Term ◽

Term Outcome ◽

Nihss Score ◽

Short Term Outcome ◽

Clot Structure

Background and Purpose. We hypothesized that patients with persistent atrial fibrillation (AF) suffer from more severe cerebral infarction than patients with paroxysmal AF due to differences in clot structure and volume. Methods. This study includes consecutive patients with acute cerebral infarction and persistent or paroxysmal AF documented by ECG any time prior to stroke onset. The National Institute of Health Stroke Scale (NIHSS) was used to assess stroke severity on admission. Short-term outcome was determined by the modified Rankin scale (mRS) score, Barthel index, and NIHSS score 7 days after stroke onset. Risk factors were registered on admission. Eligible patients were treated with thrombolysis. Results. In total, 141 (52%) patients had paroxysmal AF, and 129 (48%) patients had persistent AF. NIHSS score on admission, mRS score at day 7, and mortality were significantly higher among patients with persistent AF. Thrombolysis was less effective in patients with persistent AF. Conclusions. Our study shows that patients with persistent AF and acute cerebral infarction have poorer short-term outcome than patients with paroxysmal AF. Differences in clot structure or clot volume may explain this.

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