Risk Factors for Spontaneous Intracerebral Hemorrhage

Stroke ◽  
1995 ◽  
Vol 26 (9) ◽  
pp. 1558-1564 ◽  
Author(s):  
Seppo Juvela ◽  
Matti Hillbom ◽  
Heikki Palomäki
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Spontaneous Intracerebral Hemorrhage

Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2′-deoxyguanosine as an independent predictor of the 30-day outcome

2011 ◽  
Vol 115 (6) ◽  
pp. 1184-1190 ◽  
Author(s):  
Yi-Chun Chen ◽  
Chiung-Mei Chen ◽  
Jun-Liang Liu ◽  
Sien-Tsong Chen ◽  
Mei-Ling Cheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Vitamin E ◽  
Vitamin A ◽  
Intracerebral Hemorrhage ◽  
Redox Status ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Oxidative Markers ◽  
Traditional Risk Factors ◽  
Gpx Activity

Object Oxidative stress may play a role in spontaneous intracerebral hemorrhage (ICH), but data on oxidative burden in cerebral hemorrhage are limited, and it is not clear whether oxidative markers add predictive power regarding ICH outcome beyond that of traditional factors. The authors therefore examined redox status and traditional factors in ICH patients within 3 days of hemorrhage onset to delineate redox status in ICH and investigate the predictive value with respect to 30-day functional outcome. Methods Sixty-four patients with ICH and 114 controls were prospectively enrolled in this study. Blood samples were collected within 3 days of ICH onset and processed for isolation of plasma, erythrocytes, and leukocytes. The authors evaluated levels or activities of leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG), erythrocyte glucose-6-phosphate dehydrogenase (G6PD), erythrocyte glutathione peroxidase (GPx), plasma malondialdehyde (MDA), vitamin E, and vitamin A, as well as traditional factors including the presence of hypertension or diabetes mellitus, total cholesterol level, and measures of liver function. A general linear model and multivariable logistic regression were used for analyses where appropriate. Results After adjustment for age and sex and traditional risk factors, ICH was significantly associated with an increased level of 8-OHdG (p < 0.0001), decreased GPx activity (p = 0.0002), and a decreased level of vitamin E (p = 0.003). There was no association of ICH risk with G6PD activity or MDA or vitamin A level. Considering all the oxidative markers and traditional risk factors together, logistic regression showed an independent association of ICH with 8-OHdG (OR 2.7, 95% CI 1.7–4.2, p < 0.0001). The association between increased 8-OHdG level and lower 30-day Barthel Index was also independent of the effects of age, sex, hemorrhage location and size, and traditional factors (p = 0.026). Unfavorable outcome (modified Rankin Scale score ≥ 3) at 30 days after ICH onset was not significantly associated with any of the examined oxidative markers. Conclusions Increased leukocyte 8-OHdG levels, as well as decreased GPx activity and vitamin E levels, were found during acute ICH. Only 8-OHdG was associated with ICH and the 30-day outcome independently from the other oxidative markers and traditional factors. Leukocyte 8-OHdG may add power beyond the traditional factors in predicting ICH outcome and thus may be used as an independent surrogate for clinical ICH study.

Intracerebral Hemorrhage and Epileptic Seizures: Frequency, Localization and Seizures Types

2017 ◽  
Vol 71 (2) ◽  
pp. 119-122
Author(s):  
Dragana Petrovska Cvetkovska ◽  
Arben Taravari ◽  
Natalija Dolnenec Baneva ◽  
Dijana Nikodijevik ◽  
Coskun Kerala ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Arterial Hypertension ◽  
Computer Tomography ◽  
Large Volume ◽  
Epileptic Seizures ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Generalized Seizures ◽  
Study Population ◽  
Cortical Involvement

Abstract Introduction. Among 2.8-18.7% of the patients that suffered from spontaneous intracerebral hemorrhage (ICH) develop seizures. Previous studies suggest that most important contributors to developing subsequent seizures are: volume and localization of hematoma, cortical involvement and age. Aims: To determine the occurrence of new epileptic seizures in patients with spontaneous intracerebral hemorrhage and to analyze it with respect to the patient’s age, gender, presence of premorbid risk factors, localization of the hematoma and the type of the seizures. Methods. This study is retrospective in design, with study population of 308 patients with spontaneous intracerebral hemorrhage admitted to our clinic in the period between 2008 and 2014. Analyzed premorbid risk factors for ICH are: hypertension, smoking, alcohol uptake. According to the computer tomography (CT) of brain findings the patients was divided in two groups: lobar and thalamic (deep). By the time of presents of seizures, they were classified as early (within 1 week of ICH) or late (more than 1 week after ICH). Also we analyzed the seizures type and we divided them in four groups: simple partial, partial complex, secondary generalized and tonic clonic generalized seizures. Results. Arterial hypertension was revealed in 78% of the patients with spontaneous supratentorial ICH. Epileptic seizures developed in 8.2% of analyzed patients, most of them in the first week of brain bleeding. Lobar ICH had 78.6% of the patients, with frontal localization was 44% of patients with lobar ICH, and most of them had simple partial and partial complex seizures. Conclusion. Cortical involvement, large volume of hematoma, may be a factor for provoked seizures, especially in the first days of brain bleeding.

Multivariate analysis of risk factors of hematoma expansion in spontaneous intracerebral hemorrhage

2008 ◽  
Vol 69 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Jae Kwan Lim ◽  
Hyung Sik Hwang ◽  
Byung Moon Cho ◽  
Ho Kook Lee ◽  
Sung Ki Ahn ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Intracerebral Hemorrhage ◽  
Hematoma Expansion ◽  
Spontaneous Intracerebral Hemorrhage

scholarly journals Prevalence of and risk factors for infections in patients with spontaneous intracerebral hemorrhage at the intensive care unit

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Shengjie Feng ◽  
Miaoxian Yang ◽  
Shuixiang Deng ◽  
Feng Zhao ◽  
Peng Jin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Intracerebral Hemorrhage ◽  
Spontaneous Intracerebral Hemorrhage

scholarly journals The risk factors and prognosis of delayed perihematomal edema in patients with spontaneous intracerebral hemorrhage

2019 ◽  
Vol 25 (10) ◽  
pp. 1189-1194 ◽  
Author(s):  
Wen‐jie Peng ◽  
Qian Li ◽  
Jin‐hua Tang ◽  
Cesar Reis ◽  
Camila Araujo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Perihematomal Edema

scholarly journals Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans

Neurology ◽  
2020 ◽  
Vol 94 (10) ◽  
pp. e998-e1012 ◽  
Author(s):  
Fred S. Sarfo ◽  
Bruce Ovbiagele ◽  
Mulugeta Gebregziabher ◽  
Onoja Akpa ◽  
Albert Akpalu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Conditional Logistic Regression ◽  
Population Level ◽  
Amyloid Angiopathy ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Level Control ◽  
Factors Associated ◽  
West Africans ◽  
Population Attributable Risks

ObjectiveTo characterize risk factors for spontaneous intracerebral hemorrhage (sICH) occurrence and severity among West Africans.MethodsThe Stroke Investigative Research and Educational Network (SIREN) study is a multicenter case-control study involving 15 sites in Ghana and Nigeria. Patients were adults ≥18 years old with CT-confirmed sICH with age-, sex-, and ethnicity-matched stroke-free community controls. Standard instruments were used to assess vascular, lifestyle, and psychosocial factors. Factors associated with sICH and its severity were assessed using conditional logistic regression to estimate odds ratios (ORs) and population-attributable risks (PARs) with 95% confidence intervals (CIs) for factors.ResultsOf 2,944 adjudicated stroke cases, 854 were intracerebral hemorrhage (ICH). Mean age of patients with ICH was 54.7 ± 13.9 years, with a male preponderance (63.1%), and 77.3% were nonlobar. Etiologic subtypes of sICH included hypertension (80.9%), structural vascular anomalies (4.0%), cerebral amyloid angiopathy (0.7%), systemic illnesses (0.5%), medication-related (0.4%), and undetermined (13.7%). Eight factors independently associated with sICH occurrence by decreasing order of PAR with their adjusted OR (95% CI) were hypertension, 66.63 (20.78–213.72); dyslipidemia, 2.95 (1.84–4.74); meat consumption, 1.55 (1.01–2.38); family history of CVD, 2.22 (1.41–3.50); nonconsumption of green vegetables, 3.61 (2.07–6.31); diabetes mellitus, 2.11 (1.29–3.46); stress, 1.68 (1.03–2.77); and current tobacco use, 14.27 (2.09–97.47). Factors associated with severe sICH using an NIH Stroke Scale score >15 with adjusted OR (95% CI) were nonconsumption of leafy green vegetables, 2.03 (1.43–2.88); systolic blood pressure for each mm Hg rise, 1.01 (1.00–1.01); presence of midline shift, 1.54 (1.11–2.13); lobar ICH, 1.72 (1.16–2.55); and supratentorial bleeds, 2.17 (1.06–4.46).ConclusionsPopulation-level control of the dominant factors will substantially mitigate the burden of sICH in West Africa.

Acute hematoma expansion after spontaneous intracerebral hemorrhage: risk factors and impact on long-term prognosis

2020 ◽  
Vol 41 (9) ◽  
pp. 2503-2509
Author(s):  
Agnese Sembolini ◽  
Michele Romoli ◽  
Umberto Pannacci ◽  
Giulio Gambaracci ◽  
Piero Floridi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Hematoma Expansion ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Hemorrhage Risk ◽  
Long Term Prognosis
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